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BMC Neurology
Published in: BMC Neurology 1/2015

Open Access 01-12-2015 | Study protocol

Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study

Authors: A. Kumar, P. Kumar, S. Misra, R. Sagar, P. Kathuria, D. Vibha, S. Vivekanandhan, A. Garg, B. Kaul, S. Raghvan, S. P. Gorthi, S. Dabla, C. S. Aggarwal, Kameshwar Prasad

Published in: BMC Neurology | Issue 1/2015

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Abstract

Background

Several studies reported prognostic value of biomarker in intracerebral hemorrhagic (ICH) but they are either preliminary observation or inadequately powered to analyse independent contribution of biomarkers over and above clinical and neuroimaging data.

Objective

To examine whether the biomarker can significantly add to the predictive accuracy of prognosis of ICH.

Method/design

In a multi-centric prospective cohort study, 1020 patients with ICH within 72 hours of onset are being recruited. After obtaining written informed consent from patients/proxy, venous blood sample (10 ml) is being collected and analysed for C-reactive protein (CRP) level, S100B, Glial fibrillary acidic protein (GFAP), Troponin, change in leukocyte count and Copeptin levels. The patients are telephonically followed using stroke scales (Barthel Index and modified Rankin Scale) at 3, 6, 12 months and 2 years after the recruitment.

Discussion

This protocol will aim at predicting the short term or long term prognosis with the use of clinical, neuroimaging and biomarkers in order to help clinician to stratify patients for early referral or intervention.
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Metadata
Title
Biomarkers to enhance accuracy and precision of prediction of short-term and long-term outcome after spontaneous intracerebral haemorrhage: a study protocol for a prospective cohort study
Authors
A. Kumar
P. Kumar
S. Misra
R. Sagar
P. Kathuria
D. Vibha
S. Vivekanandhan
A. Garg
B. Kaul
S. Raghvan
S. P. Gorthi
S. Dabla
C. S. Aggarwal
Kameshwar Prasad
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2015
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-015-0384-3

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