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Open Access 01-12-2015 | Study protocol

Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)

Authors: Roslyn N. Boyd, Emmah Baque, Adina Piovesana, Stephanie Ross, Jenny Ziviani, Leanne Sakzewski, Lee Barber, Owen Lloyd, Lynne McKinlay, Koa Whittingham, Anthony C. Smith, Stephen Rose, Simona Fiori, Ross Cunnington, Robert Ware, Melinda Lewis, Tracy A. Comans, Paul A. Scuffham

Published in: BMC Neurology | Issue 1/2015

Abstract

Background

Acquired brain injury (ABI) refers to multiple disabilities arising from damage to the brain acquired after birth. Children with an ABI may experience physical, cognitive, social and emotional-behavioural impairments which can impact their ability to participate in activities of daily living (ADL). Recent developments in technology have led to the emergence of internet-delivered therapy programs. “Move it to improve it” (Mitii™) is a web-based multi-modal therapy that comprises upper limb (UL) and cognitive training within the context of meaningful physical activity. The proposed study aims to compare the efficacy of Mitii™ to usual care to improve ADL motor and processing skills, gross motor capacity, UL and executive functioning in a randomised waitlist controlled trial.

Methods/Design

Sixty independently ambulant children (30 in each group) at least 12 months post ABI will be recruited to participate in this trial. Children will be matched in pairs at baseline and randomly allocated to receive either 20 weeks of Mitii™ training (30 min per day, six days a week, with a potential total dose of 60 h) immediately, or be waitlisted for 20 weeks. Outcomes will be assessed at baseline, immediately post-intervention and at 20 weeks post-intervention. The primary outcomes will be the Assessment of Motor and Process Skills and 30 s repetition maximum of functional strength exercises (sit-to-stand, step-ups and half kneel to stand). Measures of body structure and functions, activity, participation and quality of life will assess the efficacy of Mitii™ across all domains of the International Classification of Functioning, Disability and Health framework. A subset of children will undertake three tesla (3T) magnetic resonance imaging scans to evaluate functional neurovascular changes, structural imaging, diffusion imaging and resting state functional connectivity before and after intervention.

Discussion

Mitii™ provides an alternative approach to deliver intensive therapy for children with an ABI in the convenience of the home environment. If Mitii™ is found to be effective, it may offer an accessible and inexpensive intervention option to increase therapy dose.

Trial Registration

ANZCTR12613000403730

Available only for authorised users

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Title: Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)
Authors: Roslyn N. Boyd
Emmah Baque
Adina Piovesana
Stephanie Ross
Jenny Ziviani
Leanne Sakzewski
Lee Barber
Owen Lloyd
Lynne McKinlay
Koa Whittingham
Anthony C. Smith
Stephen Rose
Simona Fiori
Ross Cunnington
Robert Ware
Melinda Lewis
Tracy A. Comans
Paul A. Scuffham
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2015
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-015-0381-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an Acquired Brain Injury (ABI)

Abstract

Background

Methods/Design

Discussion

Trial Registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/Design

Discussion

Trial Registration

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