Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Medical Genetics
Published in: BMC Medical Genetics 1/2018

Open Access 01-12-2018 | Research article

Association of glucocorticoid receptor gene polymorphism and occupational stress with hypertension in desert petroleum workers in Xinjiang, China

Authors: Ning Tao, Hua Ge, Wenfeng Wu, Hengqing An, Jiwen Liu, Xinjuan Xu

Published in: BMC Medical Genetics | Issue 1/2018

Login to get access

Abstract

Background

The aim of this study was to investigate the occupational stress and hypertension in desert petroleum workers in Xinjiang, and to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.

Methods

Using cluster sampling, 1280 desert petroleum workers of 3 petroleum fields in Xinjiang Karamay were randomly selected as the target group for this study. According to the inclusion criteria, a total of 1080 workers were included as the baseline for this study. We followed these workers for 2 years to investigate their occupational stress and hypertension. The polymorphism of GR gene was detected by polymerase chain reaction-restriction fragment length polymorphism. We applied appropriate statistical methods to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension.

Results

After 2 years of follow-up, there were 995 desert petroleum workers in the queue. The study showed that the incidence of hypertension in desert petroleum workers were 19.4%. Compared with the baseline data, the level of occupational stress increased, and with the increase of occupational stress, the incidence of hypertension was gradually increasing. A positive relationship was observed in the GR BCL1 gene polymorphisms and hypertension. Relative to the CC genotype, carries of the GG genotype had a significantly higher risk of hypertension (OR = 2.830). With the combination of genotype CG and GG, carries of CG and GG increased the risk of hypertension (adjusted OR = 2.238, 95%CI:1.104–4.940). There was no significant association between GR G678S gene polymorphisms and hypertension.

Conclusion

GR gene polymorphism and occupational stress of desert petroleum workers were important risk factors for hypertension.
Literature
1.
Tripodi D, Roedlich C, Laheux MA, Longuenesse C, Roquelaure Y, Lombrail P, et al. Stress perception among employees in a French University hospital. Occup Med(Lond). 2012;62(3):216–9.CrossRef
2.
Adriaenssens J, De Gucht V, Maes S. Causes and consequences of occupational stress in emergency nurses, a longitudinal study. J Nurs Manag. 2015;23(3):346–58.PubMedCrossRef
3.
Dåderman AM, De Colli D. The significance of the sense of coherence for various coping resources in stress situations used by police officers in on-the-beat service. Int Occup Med Environ Health. 2014;27(1):3–15.
4.
Wang Y, Ramos A, Wu H, Liu L, Yang X, Wang J, Wang L. Relationship between occupational stress and burnout among Chinese teachers: a cross-sectional survey in Liaoning, China. Int Arch Occup Environ Health. 2015;88(5):589–97.PubMedCrossRef
5.
Lin S, Liu B, Wu C, Zhou H, Courtice MN, Zhu D. Interaction between occupational stress and GR gene polymorphisms on essential hypertension among railway workers. J Occup Health. 2014;55(5):349–58.PubMedCrossRef
6.
Biglari H, Ebrahimi MH, Salehi M, Poursadeghiyan M, Ahmadnezhad I, Abbasi M. Relationship between occupational stress and cardiovascular diseases risk factors in drivers. Int J Occup Med Environ Health. 2016;29(6):895–901.PubMedCrossRef
7.
Jiang Y, Palizhati A, Gao XY, Guan SZ, Liu JW. Association between 5-hydroxytryptamine 2A receptor gene polymorphisms and susceptibility to occupational stress in oilfield workers. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016;34(10):742–5.[inChinese].
8.
Basu S, Qayyum H, Mason S. Occupational stress in the ED: a systematic literature review. Emerg Med J. 2017;34(7):441–7.PubMedCrossRef
9.
Wu H, Liu L, Wang Y, Gao F, Zhao X, Wang L. Factors associated with burnout among Chinese hospital doctors: a cross-sectional study. BMC Public Health. 2013;13:786.PubMedPubMedCentralCrossRef
10.
Bi Y, Jiang Y, He J, Xu Y, Wang L, Xu M, Zhang M, Li Y, Wang T, Dai M, et al. Status of cardiovascular health in chinese adults. J Am Coll Cardiol. 2015;65(10):1013–25.PubMedCrossRef
11.
Gerin W, James GD. Psychosocial determinants of hypertension: laboratory and field models. Blood Press Monit. 2010;15(2):93–9.PubMedCrossRef
12.
Kretova IG, Belyaeva OV, Shiraeva OI, Shiraeva OI, Komarova MV, Chygarina SE, Kostsova EA. The impact of social and psychological factors on the formation of health students during training in the higher educational institution.Gig Sanit. 2014;(4):85–90.[in Russian].
13.
Bobrovskaya L, Beard D, Bondarenko E, Beig MI, Jobling P, Walker FR, Day TA, Nalivaiko E. Does exposure to chronic stress influence blood pressure in rats? Auton Neurosci. 2013;177(2):217–23.PubMedCrossRef
14.
Gamage AU, Seneviratne Rde A. Perceived job stress and presence of hypertension among administrative officers in Sri Lanka. Asia Pac J Public Health. 2016;28(1 Suppl):41S–52S.PubMedCrossRef
15.
Gerin W, Zawadzki MJ, Brosschot JF, Thayer JF, Christenfeld NJ, Campbell TS, Smyth JM. Rumination as a mediator of chronic stress effects on hypertension:a causal model. Int J Hypertens. 2012;2012:453465.PubMedPubMedCentralCrossRef
16.
Trudel X, Brisson C, Milot A, Masse B, Vézina M. Adverse psychosocial work factors, blood pressure and hypertension incidence: repeated exposure in a 5-year prospective cohort study. J Epidemiol Community Health. 2016;70(4):402–8.PubMedCrossRef
17.
Liao J, Brunner EJ, Kumari M. Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study. PLoS One. 2013;8(12):e81020.PubMedPubMedCentralCrossRef
18.
Gross MJ, Kahn JP, Laxenaire M, Nicolas JP, Burlet C. Corticotropin-releasing factor and anorexia nervosa: reactions of the hypothalamus-pituitary-adrenal axis to neurotropic stress. Ann Endocrinol (Paris). 1994;55(6):221–8 [in French].
19.
Lian Y, Xiao J, Wang Q, Ning L, Guan S, Ge H, Li F, et al. The relationship between glucocorticoid receptor polymorphisms, stressful life events, social support, and post-traumatic stress disorder. BMC Psychiatry. 2014;14:232.PubMedPubMedCentralCrossRef
20.
Srivastava N, Prakash J, Lakhan R, Agarwal CG, Pant DC, Mittal B. Influence of Bcl-1 gene polymorphism of glucocorticoid receptor gene(NR3C1,rs41423247) on blood pressure, glucose in northern Indians. indian J Clinic Biochemical. 2011;26(2):125–30.CrossRef
21.
Radi S, Lang T, Lauwers-Cancès V, Diène E, Chatellier G, Larabi L, De Gaudemaris R. IHPAF group Job constraints and arterial hypertersion: different effects in men and women:the IHPAF II case control studyOccup Environ Med. 2005;62(10):711–7.
22.
Pandey VG, Jain S, Rana A, Puri N, Arudra SK, Mopidevi B, Kaw M, Nasjletti A, Kumar A. Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene. J Bio Chem. 2015;290(9):5749–58.CrossRef
23.
Yan YX, Dong J, Wu LJ, Shao S, Zhang J, Zhang L, Wang W, He Y, Liu YQ. Associations between polymorphisms in the glucocorticoid-receptor gene and cardiovascular risk factors in a Chinese population. J Epidemiol. 2013;23(5):389–95.PubMedPubMedCentralCrossRef
24.
Chung CC, Shimmin L, Natarajan S, Hanis CL, Boerwinkle E, Hixson JE. Glucocorticoid receptor gene variant in the 3′ untranslated region is associated with multiple measures of blood pressure. J Clin Endocrinol Metab. 2009;94:268–76.PubMedCrossRef
25.
Ljoså CH, Tyssen R, Lau B. Perceived mastery of work among shift workers in the norwegian offshore petroleum industry. Ind Health. 2013;51(2):145–53.PubMedCrossRef
26.
Marshall IJ, Wolfe CD, McKevitt C. Lay perspectives on hypertension and drug adherence: systematic review of qualitative research. BMJ. 2012;345:e3953.PubMedPubMedCentralCrossRef
27.
Kivimäki M, Nyberg ST, Fransson EI, Heikkilä K, Alfredsson L, Casini A, Clays E, De Bacquer D, Dragano N, Ferrie JE, et al. Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data. CMAJ. 2013;185(9):763–9.PubMedPubMedCentralCrossRef
28.
Rowe DJ, Dunn JR, Muntaner C. The impact of job strain on smoking cessation and relapse in the Canadian population: a cohort study. J Epidemiol Community Health. 2015;69(10):931–6.PubMedCrossRef
29.
Osipow S.H. Occupational Stress Inventory Revised Edition (OSI-R) Psychological Assessment Resources, Inc.; Odessa, FL, USA: 1998. pp. 1–15.
30.
Yang XW, Wang ZM, Jin TY, Lan YJ. Study on the occupational stress norm and its application for the marketing group, public service/safety group and production laborer group. Wei Sheng Yan Jiu 2006; 35(5), 594–598.[in Chinese].
31.
Guilbert JJ. The world health report 2002: reducing risks, promoting healthy life. 2003; 16(2):230.
32.
Lu CD, Ding QF, Wang ZX, Shao H, Sun XC, Zhang F. Investigation and analysis on occupational hazards in a carbon enterprise. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2017;35(4):273–276.[in Chinese].
33.
Manty M, Kouvonen A, Lallukka T, Lahti J, Lahelma E, Rahkonen O. Changes in working conditions and physical health functioning among midlife and ageing employees. Scand J Work Environ Health. 2015;41(6):511–8.PubMedCrossRef
34.
Khajehnasiri F, Mortazavi SB, Allameh A, Akhondzadeh S, Hashemi H. Total antioxidant capacity and malondialdehyde in depressive rotational shift workers. J Environ Public Health. 2013;2013:150693.PubMedPubMedCentralCrossRef
35.
Hoboubi N, Choobineh A, Kamari Ghanavati F, Keshavarzi S, Akbar Hosseini A. The impact of job stress and job satisfaction on workforce productivity in an Iranian petrochemical industry. Saf Health Work. 2017;8(1):67–71.PubMedCrossRef
36.
Rosen DC, Miller AB, Nakash O, Halpern L, Alegría M. Interpersonal complementarity in the mental health intake: a mixed-methods study. J Couns Psychol. 2012;59(2):185–96.PubMedCrossRef
37.
Lee H, Ahn H, Miller A, Park CG, Kim SJ. Acculturative stress, work-related psychosocial factors and depression in korean-chinese migrant workers in Korea. J Occup Health. 2012;54(3):206–14.PubMedCrossRef
38.
Havermans BM, Boot CRL, Houtman ILD, Brouwers EPM, Anema JR, van der Beek AJ. The role of autonomy and social support in the relation between psychosocial safety climate and stress in health care workers. BMC Public Health. 2017;17(1):558.PubMedPubMedCentralCrossRef
39.
Yu J, Ren X, Wang Q, He L, Wang J, Jin Y, Chen Y, Wang L, Nie Z, Guo D, Yao Y. The role of social support on occupational stress among hospital nurses. Int J Clin Exp Med. 2014;7(9):3000–4.PubMedPubMedCentral
40.
Haddad M, Waqas A, Qayyum W, Shams M, Malik S. The attitudes and beliefs of Pakistani medical practitioners about depression: a cross-sectional study in Lahore using the revised depression attitude questionnaire (R-DAQ). BMC Psychiatry. 2016;16(1):349.PubMedPubMedCentralCrossRef
41.
Goto S, Radák Z, Nyakas C, Chung HY, Naito H, Takahashi R, Nakamoto H, Abea R. Regular exercise: an effective means to reduce oxidative stress in old rats. Ann N Acad Sci. 2004;1019:471.CrossRef
42.
Li J, Siegrist J. Physical activity and risk of cardiovascular disease—a meta-analysis of prospective cohort studies. Int J Environ Res Public Health. 2012;9(2):391–407.PubMedPubMedCentralCrossRef
43.
Colgrove P, Connell KL, Lackland DT, Ordunez P, DiPette DJ. Controlling hypertension and reducing its associated morbidity and mortality in the Caribbean: implications of race and ethnicity. J Clin Hypertens (Greenwich). 2017;28.
44.
Tang L, Xu T, Li H, Zhang M, Wang A, Tong W, Xu T, Sun Y, Zhang Y. Hypertension, alcohol drinking and stroke incidence: a population-based prospective cohort study among inner Mongolians in China. J Hypertens. 2014;32(5):1091–6.PubMedCrossRef
45.
Ushakov AV, Ivanchenko VS, Gagarina AA. Psychological stress in pathogenesis of essential hypertension. Curr Hypertens Rev. 2016;12(3):203–14.PubMedCrossRef
46.
Li R, Gao X, Liu B, Ge H, Ning L, Zhao J, Liu J. Prospective cohort study to elucidate the correlation between occupational stress and hypertension risk in oil workers from Kelamayi City in the Xinjiang Uygur autonomous region of China. Int J Environ Res Public Health. 2016;14(1).
47.
Babu GR, Jotheeswaran AT, Mahapatra T, Mahapatra S, Kumar A Sr, Detels R, Pearce N. Is hypertension associated with job strain? A meta-analysis of observational studies. Occup Environ Med. 2014;71(3):220–7.PubMedCrossRef
48.
Fan LB, Blumenthal JA, Hinderliter AL, Sherwood A. The effect of job strain on nighttime blood pressure dipping among men and women with high blood pressure. Scand J Work Environ Health. 2013;39(1):112–9.PubMedCrossRef
49.
Mirmohammadi SJ, Taheri M, Mehrparvar AH, Heydari M, Kanafi AS, Mostaghaci M. Occupational stress and cardiovascular risk factors in high-ranking government officials and office workers. Iran Red Crescent Med J. 2014;16(8):e11747.PubMedPubMedCentralCrossRef
50.
Clays E, De Bacquer D, Van Herck K, De Backer G, Kittel F, Holtermann A. Occupational and leisure time physical activity in contrasting relation to ambulatory blood pressure. BMC Public Health. 2012;12:1002.PubMedPubMedCentralCrossRef
51.
Lian Y, Qi C, Tao N, Han R, Jiang Y, Guan S, Ge H, Ning L, Xiao J, Liu J. Changing work stressors and coping resources influence blood pressure and hypertension incidence in a large ohspiw cohort. J Hum Hypertens. 2017;31(5):313–9.PubMedCrossRef
52.
Rafacho A, Ortsäter H, Nadal A, Quesada I. Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes. J Endocrinol. 2014;223(3):R49–62.PubMedCrossRef
53.
Duque Ede A, Munhoz CD. The pro-inflammatory effects of glucocorticoids in the brain. Front Endocrinol (Lausanne). 2016;7:78.
54.
Van Moorsel D, Henry RM, Schaper NC, van Greevenbroek MM, van Rossum EF, 'T hart LM, Schalkwijk CG, Van der Kallen CJ, et al. BclI glucocorticoid receptor polymorphism in relation to arterial stiffening and cardiac structure and function: the Hoorn and CODAM studies. Am J Hypertens 2017;30(3):286–294.PubMed
55.
Lin S, Liu B, Wu C, Zhou H, Courtice MN, Zhu D. Interaction between occupational stress and gr gene polymorphisms on essential hypertension among railway workers. J Occup Health. 2014;55(5):349–58.PubMedCrossRef
56.
Kaur H, Luckhaupt SE, Li J, Alterman T, Calvert GM. Workplace psychosocial factors associated with hypertension in the u.S. workforce: a cross-sectional study based on the 2010 national health interview survey. Am J Ind Med. 2014;57(9):1011–21.PubMedCrossRef
Metadata
Title
Association of glucocorticoid receptor gene polymorphism and occupational stress with hypertension in desert petroleum workers in Xinjiang, China
Authors
Ning Tao
Hua Ge
Wenfeng Wu
Hengqing An
Jiwen Liu
Xinjuan Xu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2018
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/s12881-018-0688-4

Other articles of this Issue 1/2018

BMC Medical Genetics 1/2018 Go to the issue

Research article

Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a

Research article

The conserved p.Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family

Research article

Association study between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and metabolic syndrome

Research article

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Research article

Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

Research article

Novel mutations of PKD genes in Chinese patients suffering from autosomal dominant polycystic kidney disease and seeking assisted reproduction