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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2017

Open Access 01-12-2017 | Research article

Relationship between interpersonal sensitivity and leukocyte telomere length

Authors: Akihito Suzuki, Yoshihiko Matsumoto, Masanori Enokido, Toshinori Shirata, Kaoru Goto, Koichi Otani

Published in: BMC Medical Genetics | Issue 1/2017

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Abstract

Background

Telomeres are repetitive DNA sequences located at the ends of chromosomes, and telomere length represents a biological marker for cellular aging. Interpersonal sensitivity, excessive sensitivity to the behavior and feelings of others, is one of the vulnerable factors to depression. In the present study, we examined the effect of interpersonal sensitivity on telomere length in healthy subjects.

Methods

The subjects were 159 unrelated healthy Japanese volunteers. Mean age ± SD (range) of the subjects was 42.3 ± 7.8 (30–61) years. Interpersonal sensitivity was assessed by the Japanese version of the Interpersonal Sensitivity Measure (IPSM). Leukocyte telomere length was determined by a quantitative real-time PCR method.

Results

Higher scores of the total IPSM were significantly (β = −0.163, p = 0.038) related to shorter telomere length. In the sub-scale analysis, higher scores of timidity were significantly (β = −0.220, p = 0.044) associated with shorter telomere length.

Conclusions

The present study suggests that subjects with higher interpersonal sensitivity have shorter leukocyte telomere length, implying that interpersonal sensitivity has an impact on cellular aging.
Literature
1.
Boyce P, Parker G. Development of a scale to measure interpersonal sensitivity. Aust N Z J Psychiatry. 1989;23:341–51.PubMed
2.
Boyce P, Parker G, Barnett B, Cooney M, Smith F. Personality as a vulnerability factor to depression. Br J Psychiatry. 1991;159:106–14.CrossRefPubMed
3.
Evans J, Heron J, Lewis G, Araya R, Wolke D. Negative self-schemas and the onset of depression in women: longitudinal study. Br J Psychiatry. 2005;186:302–7.CrossRefPubMed
4.
Boyce P, Hickie I, Parker G, Mitchell P, Wilhelm K, Brodaty H. Specificity of interpersonal sensitivity to non-melancholic depression. J Affect Disord. 1993;27:101–5.CrossRefPubMed
5.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
6.
Hamann DM, Wonderlich-Tierney AL, Vander Wal JS. Interpersonal sensitivity predicts bulimic symptomatology cross-sectionally and longitudinally. Eat Disord. 2009;10:125–7.
7.
Brook JS, Zhang C, Brook DW, Koppel J, Whiteman M. Psychosocial predictors of nicotine dependence among women during their mid-sixties. Am J Addict. 2012;21:302–12.CrossRefPubMedPubMedCentral
8.
Rae AM, Joyce PR, Luty SE, Mulder RT. The effect of a history of alcohol dependence in adult major depression. J Affect Disord. 2002;70:281–90.CrossRefPubMed
9.
Tops M, Riese H, Oldehinkel AJ, Rijsdijk FV, Ormel J. Rejection sensitivity relates to hypocortisolism and depressed mood state in young women. Psychoneuroendocrinology. 2008;33:551–9.CrossRefPubMed
10.
Hori H, Ozeki Y, Teraishi T, Matsuo J, Kawamoto Y, Kinoshita Y, Suto S, Terada S, Higuchi T, Kunugi H. Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults. J Psychiatr Res. 2010;44:865–73.CrossRefPubMed
11.
Stroud LR, Salovey P, Epel ES. Sex differences in stress responses: social rejection versus achievement stress. Biol Psychiatry. 2002;52:318–27.CrossRefPubMed
12.
Blackhart GC, Eckel LA, Tice DM. Salivary cortisol in response to acute social rejection and acceptance by peers. Biol Psychol. 2007;75:267–76.CrossRefPubMed
13.
14.
Mather KA, Jorm AF, Parslow RA, Christensen H. Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci. 2011;66:202–13.CrossRefPubMed
15.
Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, Packard CJ, Samani NJ. West of Scotland Coronary Prevention Study Group: Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369:107–14.CrossRefPubMed
16.
Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2014;349:g4227.CrossRefPubMedPubMedCentral
17.
Ma H, Zhou Z, Wei S, Liu Z, Pooley KA, Dunning AM, Svenson U, Roos G, Hosgood HD III, Shen M, Wei Q. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One. 2011;6:e20466.CrossRefPubMedPubMedCentral
18.
Sanchez-Espiridion B, Chen M, Chang JY, Lu C, Chang DW, Roth JA, Wu X, Gu J. Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res. 2014;74:2476–86.CrossRefPubMedPubMedCentral
19.
Fyhrquist F, Tiitu A, Saijonmaa O, Forsblom C, Groop PH. FinnDiane Study Group: Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med. 2010;267:278–86.CrossRefPubMed
20.
Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, Von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol. 2006;60:174–80.CrossRefPubMed
21.
Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393–5.CrossRefPubMed
22.
Rode L, Nordestgaard BG, Bojesen SE. Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general population. J Natl Cancer Inst. 2015;107:djv074.CrossRefPubMed
23.
24.
O’Donovan A, Lin J, Tillie J, Dhabhar FS, Wolkowitz OM, Blackburn EH, Epel ES. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun. 2009;23:446–9.CrossRefPubMed
25.
Ikeda A, Schwartz J, Peters JL, Baccarelli AA, Hoxha M, Dioni L, Spiro A, Sparrow D, Vokonas P, Kubzansky LD. Pessimistic orientation in relation to telomere length in older men: the VA normative aging study. Psychoneuroendocrinology. 2014;42:68–76.CrossRefPubMedPubMedCentral
26.
van Ockenburg SL, de Jonge P, van der Harst P, Ormel J, Rosmalen JG. Does neuroticism make you old? Prospective associations between neuroticism and leukocyte telomere length. Psychol Med. 2014;44:723–9.CrossRefPubMed
27.
Brydon L, Lin J, Butcher L, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A. Hostility and cellular aging in men from the Whitehall II cohort. Biol Psychiatry. 2012;71:767–73.CrossRefPubMedPubMedCentral
28.
Kuwabara H, Sakado K, Uehara T, Sakado M, Sato T, Someya T. The Japanese version of Interpersonal Sensitivity Measure: its reliability and validity. Seishinkashindangaku. 1999;10:333–41. (in Japanese)
29.
Boyce P, Harris M, Silove D, Morgan A, Wilhelm H, Hadzi-Pavlovic D. Psychosocial factors associated with depression: A study of socially disadvantaged women with young children. J Nerv Ment Dis. 1998;186:3–11.CrossRefPubMed
30.
31.
Sadahiro R, Suzuki A, Enokido M, Matsumoto Y, Shibuya N, Kamata M, Goto K, Otani K. Relationship between leukocyte telomere length and personality traits in healthy subjects. Eur Psychiatry. 2015;30:291–5.CrossRefPubMed
32.
Enokido M, Suzuki A, Sadahiro R, Matsumoto Y, Kuwahata F, Takahashi N, Goto K, Otani K. Parental care influences leukocyte telomere length with gender specificity in parents and offsprings. BMC Psychiatry. 2014;14:277.CrossRefPubMedPubMedCentral
33.
Lee KU, Jung NY, Rauch SA, Chae JH, Lee HK, Kweon YS, Lee CT. Psychometric properties of the Korean version of the Interpersonal Sensitivity Measure (IPSM-K). Compr Psychiatry. 2013;54:918–24.CrossRefPubMed
34.
Portella MJ, Harmer CJ, Flint J, Cowen P, Goodwin GM. Enhanced early morning salivary cortisol in neuroticism. Am J Psychiatry. 2005;162:807–9.CrossRefPubMed
35.
36.
Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology. 2006;31:277–87.CrossRefPubMed
37.
Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312–5.CrossRefPubMedPubMedCentral
Metadata
Title
Relationship between interpersonal sensitivity and leukocyte telomere length
Authors
Akihito Suzuki
Yoshihiko Matsumoto
Masanori Enokido
Toshinori Shirata
Kaoru Goto
Koichi Otani
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2017
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/s12881-017-0473-9

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