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Open Access 01-12-2015 | Research article

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

Authors: Shafqat Ahmad, Wei Zhao, Frida Renström, Asif Rasheed, Maria Samuel, Mozzam Zaidi, Nabi Shah, Nadeem Hayyat Mallick, Khan Shah Zaman, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rheman Memon, Bashir Hanif, Muhammad Shakir Lakhani, Faisal Ahmed, Shahana Urooj Kazmi, Philippe Frossard, Paul W. Franks, Danish Saleheen

Published in: BMC Medical Genetics | Issue 1/2015

Abstract

Background

Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.

Methods

In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age², sex, MI (yes/no), and population substructure.

Results

Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m² higher BMI (P = 4.5 × 10⁻¹⁴). We observed nominal evidence of interactions of CLIP1 rs11583200 (P _interaction = 0.014), CADM2 rs13078960 (P _interaction = 0.037) and GALNT10 rs7715256 (P _interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P _interaction = 0.045), HIP1 rs1167827 (P _interaction = 0.015), C6orf106 rs205262 (P _interaction = 0.032) and GRID1 rs7899106 (P _interaction = 0.043) with smoking on BMI.

Conclusions

Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.

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Title: Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study
Authors: Shafqat Ahmad
Wei Zhao
Frida Renström
Asif Rasheed
Maria Samuel
Mozzam Zaidi
Nabi Shah
Nadeem Hayyat Mallick
Khan Shah Zaman
Mohammad Ishaq
Syed Zahed Rasheed
Fazal-ur-Rheman Memon
Bashir Hanif
Muhammad Shakir Lakhani
Faisal Ahmed
Shahana Urooj Kazmi
Philippe Frossard
Paul W. Franks
Danish Saleheen
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2015
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/s12881-015-0259-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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