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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2020

Open Access 01-12-2020 | Research article

Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?

Authors: Yu-Chuan Hu, Lin-Feng Yan, Yu Han, Shi-Jun Duan, Qian Sun, Gang-Feng Li, Wen Wang, Xiao-Cheng Wei, Dan-Dan Zheng, Guang-Bin Cui

Published in: BMC Medical Imaging | Issue 1/2020

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Abstract

Background

Our study aims to reveal whether the low b-values distribution, high b-values upper limit, and the number of excitation (NEX) influence the accuracy of the intravoxel incoherent motion (IVIM) parameter derived from multi-b-value diffusion-weighted imaging (DWI) in the brain.

Methods

This prospective study was approved by the local Ethics Committee and informed consent was obtained from each participant. The five consecutive multi-b DWI with different b-value protocols (0–3500 s/mm2) were performed in 22 male healthy volunteers on a 3.0-T MRI system. The IVIM parameters from normal white matter (WM) and gray matter (GM) including slow diffusion coefficient (D), fast perfusion coefficient (D*) and perfusion fraction (f) were compared for differences among defined groups with different IVIM protocols by one-way ANOVA.

Results

The D* and f value of WM or GM in groups with less low b-values distribution (less than or equal to 5 b-values) were significantly lower than ones in any other group with more low b-values distribution (all P <  0.05), but no significant differences among groups with more low b-values distribution (P > 0.05). In addition, no significant differences in the D, D* and f value of WM or GM were found between group with one and more NEX of low b-values distribution (all P > 0.05). IVIM parameters in normal WM and GM strongly depended on the choice of the high b-value upper limit.

Conclusions

Metrics of IVIM parameters can be affected by low and high b value distribution. Eight low b-values distribution with high b-value upper limit of 800–1000 s/mm2 may be the relatively proper set when performing brain IVIM studies.
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Metadata
Title
Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?
Authors
Yu-Chuan Hu
Lin-Feng Yan
Yu Han
Shi-Jun Duan
Qian Sun
Gang-Feng Li
Wen Wang
Xiao-Cheng Wei
Dan-Dan Zheng
Guang-Bin Cui
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2020
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-020-0419-0

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