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BMC Medical Imaging

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Open Access 01-12-2018 | Research article

A prospective study to evaluate the intra-individual reproducibility of bone scans for quantitative assessment in patients with metastatic prostate cancer

Authors: Mariana Reza, Reza Kaboteh, May Sadik, Anders Bjartell, Per Wollmer, Elin Trägårdh

Published in: BMC Medical Imaging | Issue 1/2018

Abstract

Background

The Bone Scan Index (BSI) is used to quantitatively assess the total tumour burden in bone scans of patients with metastatic prostate cancer. The clinical utility of BSI has recently been validated as a prognostic imaging biomarker. However, the clinical utility of the on-treatment change in BSI is dependent on the reproducibility of bone scans. The objective of this prospective study is to evaluate the intra-patient reproducibility of two bone scan procedures performed at a one-week interval.

Methods

We prospectively studied prostate cancer patients who were referred for bone scintigraphy at our centres according to clinical routine. All patients underwent two whole-body bone scans: one for clinical routine purposes and a second one as a repeated scan after approximately one week. BSI values were obtained for each bone scintigraph using EXINI bone^BSI software.

Results

A total of 20 patients were enrolled. There was no statistical difference between the BSI values of the first (median = 0.66, range 0–40.77) and second (median = 0.63, range 0–22.98) bone scans (p = 0.41). The median difference in BSI between the clinical routine and repeated scans was − 0.005 (range − 17.79 to 0). The 95% confidence interval for the median value was − 0.1 to 0. A separate analysis was performed for patients with BSI ≤ 10 (n = 17). Differences in BSI were smaller for patients with BSI ≤ 10 compared to the whole cohort (median − 0.1, range − 2.2-0, 95% confidence interval − 0.1 to 0).

Conclusions

The automated BSI demonstrated high intra-individual reproducibility for BSI ≤ 10 in the two repeated bone scans of patients with prostate cancer. The study supports the use of BSI as a quantitative parameter to evaluate the change in total tumour burden in bone scans.

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Title: A prospective study to evaluate the intra-individual reproducibility of bone scans for quantitative assessment in patients with metastatic prostate cancer
Authors: Mariana Reza
Reza Kaboteh
May Sadik
Anders Bjartell
Per Wollmer
Elin Trägårdh
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Medical Imaging / Issue 1/2018
Electronic ISSN: 1471-2342
DOI: https://doi.org/10.1186/s12880-018-0257-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A prospective study to evaluate the intra-individual reproducibility of bone scans for quantitative assessment in patients with metastatic prostate cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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