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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2016

Open Access 01-12-2016 | Research article

Comparison of coronary arterial lumen dimensions on angiography and plaque characteristics on optical coherence tomography images and their changes induced by statin

Authors: Nana Dong, Zulong Xie, Wei Wang, Jiannan Dai, Meng Sun, Zhongyue Pu, Jinwei Tian, Bo Yu

Published in: BMC Medical Imaging | Issue 1/2016

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Abstract

Background

Coronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence tomography (OCT) is used to evaluate the characteristics of atherosclerotic plaque. This study was aimed to compare coronary lumen dimensions using CAG and plaque characteristics using OCT and their changes during statin therapy.

Methods

We identified 97 lipid-rich plaques from 69 statin-naïve patients, who received statin therapy in the following 12 months. CAG and OCT examinations were conducted at baseline and 12-month follow-up period.

Results

Lesion length, as measured by CAG, was closely correlated with lipid length by OCT (baseline: r = 0.754, p < 0.001; follow-up: r = 0.639, p < 0.001). However, no significant correlations were found between the other findings on OCT and data on CAG. With 12-month statin therapy, microstructures of lipid-rich plaques were significantly improved, but CAG-derived lumen dimensions were not improved. Moreover, we found no significant relationship between changes in OCT measurements and changes in CAG data over time.

Conclusion

Lipid length on OCT and lesion length on CAG were closely correlated. However, plaque microstructural characteristics on OCT showed no significantly statistically correlations with lumen dimensions on CAG, neither did their evolutionary changes induced by statin over time.

A retrospectively registered study

Clinical trial registry: ClinicalTrial.gov. Registered number: NCT01023607. Registered 1 December 2009.
Literature
1.
Fuster V, Fayad ZA, Badimon JJ. Acute coronary syndromes: biology. Lancet. 1999;353 Suppl 2:SII5–9.CrossRefPubMed
2.
Toschi V, Gallo R, Lettino M, Fallon JT, Gertz SD, Fernandez-Ortiz A, et al. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation. 1997;95:594–9.CrossRefPubMed
3.
Tian J, Dauerman H, Toma C, Samady H, Itoh T, Kuramitsu S, et al. Prevalence and characteristics of TCFA and degree of coronary artery stenosis: an OCT, IVUS, and angiographic study. J Am Coll Cardiol. 2014;64:672–80.CrossRefPubMed
4.
Yonetsu T, Bouma BE, Kato K, Fujimoto JG, Jang IK. Optical coherence tomography- 15 years in cardiology. Circ J. 2013;77:1933–40.CrossRefPubMed
5.
Hou J, Xing L, Jia H, Vergallo R, Soeda T, Minami Y, et al. Comparison of Intensive Versus Moderate Lipid-Lowering Therapy on Fibrous Cap and Atheroma Volume of Coronary Lipid-Rich Plaque Using Serial Optical Coherence Tomography and Intravascular Ultrasound Imaging. Am J Cardiol. 2016;117:800–6.CrossRefPubMed
6.
Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, et al. Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med. 2011;365:2078–87.CrossRefPubMed
7.
Goh VK, Lau CP, Mohlenkamp S, Rumberger JA, Achenbach S, Budoff MJ. Outcome of coronary plaque burden: a 10-year follow-up of aggressive medical management. Cardiovasc Ultrasound. 2010;8:5.CrossRefPubMedPubMedCentral
8.
Kubo T, Imanishi T, Takarada S, Kuroi A, Ueno S, Yamano T, et al. Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol. 2007;50:933–9.CrossRefPubMed
9.
Toutouzas K, Stathogiannis K, Synetos A, Karanasos A, Stefanadis C. Vulnerable atherosclerotic plaque: from the basic research laboratory to the clinic. Cardiology. 2012;123:248–53.CrossRefPubMed
10.
Xie Z, Tian J, Ma L, Du H, Dong N, et al. Comparison of optical coherence tomography and intravascular ultrasound for evaluation of coronary lipid-rich atherosclerotic plaque progression and regression. Eur Heart J Cardiovasc Imaging. 2015;16:1374–80.CrossRefPubMed
11.
12.
Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thrombosis Vasc Biol. 2000;20:1262–75.CrossRef
13.
Jang IK, Bouma BE, Kang DH, Park SJ, Park SW, Seung KB, et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol. 2002;20(39):604–9.CrossRef
14.
Kan J, Gao X, Sandeep KG, Xu H, Zhao Y, Chen S, et al. Comparison of two and three dimensional quantitative coronary angiography to intravascular ultrasound in the assessment of left main coronary artery bifurcation lesions. Chin Med J (Engl). 2014;127:1012–21.
15.
Feld S, Ganim M, Carell ES, Kjellgren O, Kirkeeide RL, Vaughn WK, et al. Comparison of angioscopy, intravascular ultrasound imaging and quantitative coronary angiography in predicting clinical outcome after coronary intervention in high risk patients. J Am Coll Cardioly. 1996;28:97–105.CrossRef
16.
van Velzen JE, de Graaf FR, Jukema JW, de Grooth GJ, Pundziute G, Kroft LJ, et al. Comparison of the relation between the calcium score and plaque characteristics in patients with acute coronary syndrome versus patients with stable coronary artery disease, assessed by computed tomography angiography and virtual histology intravascular ultrasound. Am J Cardiol. 2011;108:658–64.CrossRefPubMed
17.
18.
Kato K, Yonetsu T, Kim SJ, Xing L, Lee H, McNulty I, Yeh RW, et al. Comparison of nonculprit coronary plaque characteristics between patients with and without diabetes: a 3-vessel optical coherence tomography study. JACC Cardiovasc interv. 2012;5:1150–8.CrossRefPubMed
19.
Jin QH, Chen YD, Jing J, Tian F, Guo J, Liu CF, et al. Incidence, predictors, and clinical impact of tissue prolapse after coronary intervention: an intravascular optical coherence tomography study. Cardiology. 2011;119:197–203.CrossRefPubMed
20.
Lee SJ, Kim BK, Kim JS, Ko YG, Choi D, Jang Y, et al. Evaluation of neointimal morphology of lesions with or without in-stent restenosis: an optical coherence tomography study. Clin Cardiol. 2011;34:633–9.CrossRefPubMed
21.
Tearney GJ, Waxman S, Shishkov M, Vakoc BJ, Suter MJ, Freilich MI, et al. Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging. JACC Cardiovasc Imaging. 2008;1:752–61.CrossRefPubMedPubMedCentral
22.
Takano M, Yamamoto M, Seino Y, Mizuno K. Thrombus in sirolimus-eluting stent identified by optical coherence tomography. Clin Cardiol. 2010;33, E60.CrossRefPubMed
23.
Hanson ID, Goldstein JA, Dixon SR, Stone GW. Comparison of coronary artery lesion length by NIRS-IVUS versus angiography alone. Coron Artery Dis. 2015;26:484–9.CrossRefPubMed
24.
Pundziute G, Schuijf JD, Jukema JW, Boersma E, de Roos A, van der Wall EE, et al. Prognostic value of multislice computed tomography coronary angiography in patients with known or suspected coronary artery disease. J Am Coll Cardiol. 2007;49:62–70.CrossRefPubMed
25.
Virmani R, Burke A, Farb A. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. Eur Heart J. 1998;19:678–80.PubMed
26.
Kume T, Akasaka T, Kawamoto T, Okura H, Watanabe N, Toyota E, et al. Measurement of the thickness of the fibrous cap by optical coherence tomography. Am Heart J. 2006;152:755. e1–4.CrossRefPubMed
27.
Sato A, Aonuma K. Role of cardiac multidetector computed tomography beyond coronary angiography. Circ J. 2015;79:712–20.CrossRefPubMed
28.
Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H, et al. Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques. Eur Heart J. 2012;33:78–85.CrossRefPubMed
Metadata
Title
Comparison of coronary arterial lumen dimensions on angiography and plaque characteristics on optical coherence tomography images and their changes induced by statin
Authors
Nana Dong
Zulong Xie
Wei Wang
Jiannan Dai
Meng Sun
Zhongyue Pu
Jinwei Tian
Bo Yu
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2016
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-016-0166-4

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