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Published in: BMC Primary Care 1/2021

Open Access 01-12-2021 | Care | Research

Learning health systems in primary care: a systematic scoping review

Authors: Danielle M. Nash, Zohra Bhimani, Jennifer Rayner, Merrick Zwarenstein

Published in: BMC Primary Care | Issue 1/2021

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Abstract

Background

Learning health systems have been gaining traction over the past decade. The purpose of this study was to understand the spread of learning health systems in primary care, including where they have been implemented, how they are operating, and potential challenges and solutions.

Methods

We completed a scoping review by systematically searching OVID Medline®, Embase®, IEEE Xplore®, and reviewing specific journals from 2007 to 2020. We also completed a Google search to identify gray literature.

Results

We reviewed 1924 articles through our database search and 51 articles from other sources, from which we identified 21 unique learning health systems based on 62 data sources. Only one of these learning health systems was implemented exclusively in a primary care setting, where all others were integrated health systems or networks that also included other care settings. Eighteen of the 21 were in the United States. Examples of how these learning health systems were being used included real-time clinical surveillance, quality improvement initiatives, pragmatic trials at the point of care, and decision support. Many challenges and potential solutions were identified regarding data, sustainability, promoting a learning culture, prioritization processes, involvement of community, and balancing quality improvement versus research.

Conclusions

We identified 21 learning health systems, which all appear at an early stage of development, and only one was primary care only. We summarized and provided examples of integrated health systems and data networks that can be considered early models in the growing global movement to advance learning health systems in primary care.
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Literature
6.
go back to reference Institute of Medicine Roundtable on Evidence-Based Medicine, Olsen L, Aisner D, McGinnis J. The learning health care system: workshop summary. 2007. Institute of Medicine Roundtable on Evidence-Based Medicine, Olsen L, Aisner D, McGinnis J. The learning health care system: workshop summary. 2007.
8.
go back to reference Budrionis A, Bellika JG. The learning healthcare system: where are we now? A systematic review. J Biomed Inform. 2016;64:87–92.PubMedCrossRef Budrionis A, Bellika JG. The learning healthcare system: where are we now? A systematic review. J Biomed Inform. 2016;64:87–92.PubMedCrossRef
10.
go back to reference Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.CrossRefPubMed Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.CrossRefPubMed
11.
go back to reference Peters MD, Godfrey CM, McInerney P, Khalil H, Parker D, Baldini SC. 2017 Guidance for the conduct of JBI scoping reviews: chapter 11 scoping reviews. Joana Briggs Inst Rev Man. 2015;13(3):141–6. Peters MD, Godfrey CM, McInerney P, Khalil H, Parker D, Baldini SC. 2017 Guidance for the conduct of JBI scoping reviews: chapter 11 scoping reviews. Joana Briggs Inst Rev Man. 2015;13(3):141–6.
13.
go back to reference Rahm AK, Ladd I, Burnett-Hartman AN, Epstein MM, Lowery JT, Lu CY, et al. The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine. eGEMs. 2019;7(1):1–9.CrossRef Rahm AK, Ladd I, Burnett-Hartman AN, Epstein MM, Lowery JT, Lu CY, et al. The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine. eGEMs. 2019;7(1):1–9.CrossRef
14.
go back to reference Priest EL, Klekar C, Cantu G, Berryman C, Garinger G, Hall L, et al. Developing electronic data methods infrastructure to participate in collaborative research networks. eGEMs. 2014;2(1):18.CrossRef Priest EL, Klekar C, Cantu G, Berryman C, Garinger G, Hall L, et al. Developing electronic data methods infrastructure to participate in collaborative research networks. eGEMs. 2014;2(1):18.CrossRef
15.
18.
go back to reference Psek W, Davis FD, Gerrity G, Stametz R, Bailey-Davis L, Henninger D, et al. Operationalizing the learning health care system in an integrated delivery system. eGEMs. 2016;4(3):6.CrossRef Psek W, Davis FD, Gerrity G, Stametz R, Bailey-Davis L, Henninger D, et al. Operationalizing the learning health care system in an integrated delivery system. eGEMs. 2016;4(3):6.CrossRef
20.
go back to reference Psek WA, Stametz RA, Bailey-Davis LD, Davis D. Operationalizing the learning health care system in an integrated delivery system. eGEMs. 2015;3(1):6.CrossRef Psek WA, Stametz RA, Bailey-Davis LD, Davis D. Operationalizing the learning health care system in an integrated delivery system. eGEMs. 2015;3(1):6.CrossRef
21.
go back to reference Clarke D, Gerrity G, Stametz R, Young A, Davis D. Organizational learning in an integrated health system: informing operations for a learning health care system. J Patient Cent Res Rev. 2017;4:193–4.CrossRef Clarke D, Gerrity G, Stametz R, Young A, Davis D. Organizational learning in an integrated health system: informing operations for a learning health care system. J Patient Cent Res Rev. 2017;4:193–4.CrossRef
22.
go back to reference Williams MS, Buchanan AH, Davis FD, Faucett WA, Hallquist MLG, Leader JB, et al. Patient-centered precision health in a learning health care system: Geisinger’s genomic medicine experience. Health Aff. 2018;37(5):757–64 Available from: 29733722 NS-.CrossRef Williams MS, Buchanan AH, Davis FD, Faucett WA, Hallquist MLG, Leader JB, et al. Patient-centered precision health in a learning health care system: Geisinger’s genomic medicine experience. Health Aff. 2018;37(5):757–64 Available from: 29733722 NS-.CrossRef
25.
go back to reference Knighton AJ, Savitz L, Belnap T, Stephenson B, VanDerslice J. Introduction of an area deprivation index measuring patient socio-economic status in an integrated health system: implications for population health. eGEMs. 2016;4(3):9.CrossRef Knighton AJ, Savitz L, Belnap T, Stephenson B, VanDerslice J. Introduction of an area deprivation index measuring patient socio-economic status in an integrated health system: implications for population health. eGEMs. 2016;4(3):9.CrossRef
26.
go back to reference McGuire MJ. Building learning health care systems in primary care. Qual Manag Health Care. 2019;28(4):252–3.PubMedCrossRef McGuire MJ. Building learning health care systems in primary care. Qual Manag Health Care. 2019;28(4):252–3.PubMedCrossRef
27.
go back to reference Steiner JF, Shainline MR, Bishop MC, Xu S. Reducing missed primary care appointments in a learning health system. Med Care. 2016;54(7):689–96.PubMedCrossRef Steiner JF, Shainline MR, Bishop MC, Xu S. Reducing missed primary care appointments in a learning health system. Med Care. 2016;54(7):689–96.PubMedCrossRef
31.
go back to reference Schmittdiel JA, Dlott RS, Young JD, Rothman MB, Dyer W, Adams AS. The delivery science rapid analysis program: a research and operational partnership at Kaiser Permanente Northern California. Learn Heal Syst. 2017;1(4):e10035.CrossRef Schmittdiel JA, Dlott RS, Young JD, Rothman MB, Dyer W, Adams AS. The delivery science rapid analysis program: a research and operational partnership at Kaiser Permanente Northern California. Learn Heal Syst. 2017;1(4):e10035.CrossRef
33.
go back to reference Danforth KN, Smith AE, Loo RK, Jacobsen SJ, Mittman BS, Kanter MH, et al. Electronic clinical surveillance to improve outpatient care: diverse applications within an integrated delivery system. eGEMs. 2014;2(1):9.CrossRef Danforth KN, Smith AE, Loo RK, Jacobsen SJ, Mittman BS, Kanter MH, et al. Electronic clinical surveillance to improve outpatient care: diverse applications within an integrated delivery system. eGEMs. 2014;2(1):9.CrossRef
35.
go back to reference Henry SL, Mohan Y, Whittaker JL, Koster MA, Schottinger JE, Kanter MH. E-SCOPE: a strategic approach to identify and accelerate implementation of evidence-based best practices. Med Care. 2019;57(10):S239–45.PubMedPubMedCentralCrossRef Henry SL, Mohan Y, Whittaker JL, Koster MA, Schottinger JE, Kanter MH. E-SCOPE: a strategic approach to identify and accelerate implementation of evidence-based best practices. Med Care. 2019;57(10):S239–45.PubMedPubMedCentralCrossRef
36.
go back to reference Greene SM, Reid RJ, Larson EB. Implementing the learning health system: from concept to action. Ann Intern Med. 2012;157:207–10.PubMedCrossRef Greene SM, Reid RJ, Larson EB. Implementing the learning health system: from concept to action. Ann Intern Med. 2012;157:207–10.PubMedCrossRef
39.
go back to reference Horwitz LI, Kuznetsova M, Jones SA. Creating a learning health system through rapid-cycle, randomized testing. N Engl J Med. 2019;381(12):1175–9.PubMedCrossRef Horwitz LI, Kuznetsova M, Jones SA. Creating a learning health system through rapid-cycle, randomized testing. N Engl J Med. 2019;381(12):1175–9.PubMedCrossRef
44.
go back to reference Atkins D, Kilbourne AM, Shulkin D. Moving from discovery to system-wide change: the role of research in a learning health care system: experience from three decades of health systems research in the Veterans Health Administration. Annu Rev Public Heal. 2017;38:467–87.CrossRef Atkins D, Kilbourne AM, Shulkin D. Moving from discovery to system-wide change: the role of research in a learning health care system: experience from three decades of health systems research in the Veterans Health Administration. Annu Rev Public Heal. 2017;38:467–87.CrossRef
45.
go back to reference Kilbourne AM, Elwy AR, Sales AE, Atkins D. Accelerating research impact in a learning health care system. Med Care. 2017;55(7):S4-12.PubMedCrossRef Kilbourne AM, Elwy AR, Sales AE, Atkins D. Accelerating research impact in a learning health care system. Med Care. 2017;55(7):S4-12.PubMedCrossRef
47.
go back to reference Frakt AB, Prentice JC, Pizer SD, Elwy AR, Garrido MM, Kilbourne AM, et al. Overcoming challenges to evidence-based policy development in a large, integrated delivery system. Health Serv Res. 2018;53(6):4789–807.PubMedPubMedCentralCrossRef Frakt AB, Prentice JC, Pizer SD, Elwy AR, Garrido MM, Kilbourne AM, et al. Overcoming challenges to evidence-based policy development in a large, integrated delivery system. Health Serv Res. 2018;53(6):4789–807.PubMedPubMedCentralCrossRef
48.
go back to reference Kilbourne AM, Goodrich DE, Miake-Lye I, Braganza MZ, Bowersox NW. Quality enhancement research initiative implementation roadmap: toward sustainability of evidence-based practices in a learning health system. Med Care. 2019;57(10):S286–93.PubMedPubMedCentralCrossRef Kilbourne AM, Goodrich DE, Miake-Lye I, Braganza MZ, Bowersox NW. Quality enhancement research initiative implementation roadmap: toward sustainability of evidence-based practices in a learning health system. Med Care. 2019;57(10):S286–93.PubMedPubMedCentralCrossRef
49.
go back to reference Garrido MM, Allman RM, Pizer SD, Rudolph JL, Thomas KS, Sperber NR, et al. Innovation in a learning health care system: veteran-directed home- and community-based services. J Am Geriatr Soc. 2017;65(11):2446–51.PubMedPubMedCentralCrossRef Garrido MM, Allman RM, Pizer SD, Rudolph JL, Thomas KS, Sperber NR, et al. Innovation in a learning health care system: veteran-directed home- and community-based services. J Am Geriatr Soc. 2017;65(11):2446–51.PubMedPubMedCentralCrossRef
51.
go back to reference Wu RR, Kinsinger LS, Provenzale D, King HA, Akerly P, Barnes LK, et al. Implementation of new clinical programs in the VHA Healthcare System: the importance of early collaboration between clinical leadership and research. J Gen Intern Med. 2014;29(4):825–30.PubMedPubMedCentralCrossRef Wu RR, Kinsinger LS, Provenzale D, King HA, Akerly P, Barnes LK, et al. Implementation of new clinical programs in the VHA Healthcare System: the importance of early collaboration between clinical leadership and research. J Gen Intern Med. 2014;29(4):825–30.PubMedPubMedCentralCrossRef
52.
go back to reference Kilbourne AM, Braganza MZ, Bowersox NW, Goodrich DE, Miake-Lye I, Floyd N, et al. Research lifecycle to increase the substantial real-world impact of research: accelerating innovations to application. Med Care. 2019;57(10):S206–12.PubMedPubMedCentralCrossRef Kilbourne AM, Braganza MZ, Bowersox NW, Goodrich DE, Miake-Lye I, Floyd N, et al. Research lifecycle to increase the substantial real-world impact of research: accelerating innovations to application. Med Care. 2019;57(10):S206–12.PubMedPubMedCentralCrossRef
54.
go back to reference Steels S, Van Staa T. Evaluation protocol of the implementation of a learning healthcare system in clinical practice: The Connected Health Cities programme in the north of England. BMJ Open. 2019;9(6):e025484.PubMedPubMedCentralCrossRef Steels S, Van Staa T. Evaluation protocol of the implementation of a learning healthcare system in clinical practice: The Connected Health Cities programme in the north of England. BMJ Open. 2019;9(6):e025484.PubMedPubMedCentralCrossRef
55.
go back to reference Turley CB. Leveraging a statewide clinical data warehouse to expand boundaries of the learning health system. eGEMs. 2016;4(1):25.CrossRef Turley CB. Leveraging a statewide clinical data warehouse to expand boundaries of the learning health system. eGEMs. 2016;4(1):25.CrossRef
57.
go back to reference Starren JB, Winter AQ, Lloyd-Jones DM. Enabling a learning health system through a unified enterprise data warehouse: the experience of the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. Clin Transl Sci. 2015;8(4):269–71.PubMedPubMedCentralCrossRef Starren JB, Winter AQ, Lloyd-Jones DM. Enabling a learning health system through a unified enterprise data warehouse: the experience of the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. Clin Transl Sci. 2015;8(4):269–71.PubMedPubMedCentralCrossRef
59.
go back to reference Boes S, Mantwill S, Kaufmann C, Brach M, Bickenbach J, Rubinelli S, et al. Swiss Learning Health System: a national initiative to establish learning cycles for continuous health system improvement. Learn Heal Syst. 2018;2(3):2–7. Boes S, Mantwill S, Kaufmann C, Brach M, Bickenbach J, Rubinelli S, et al. Swiss Learning Health System: a national initiative to establish learning cycles for continuous health system improvement. Learn Heal Syst. 2018;2(3):2–7.
62.
go back to reference Delaney BC, Curcin V, Andreasson A, Arvanitis TN, Bastiaens H, Corrigan D, et al. Translational medicine and patient safety in Europe: TRANSFoRm - architecture for the learning health system in Europe. Biomed Res Int. 2015;2015:1–8.CrossRef Delaney BC, Curcin V, Andreasson A, Arvanitis TN, Bastiaens H, Corrigan D, et al. Translational medicine and patient safety in Europe: TRANSFoRm - architecture for the learning health system in Europe. Biomed Res Int. 2015;2015:1–8.CrossRef
63.
go back to reference Ethier JF, McGilchrist M, Barton A, Cloutier AM, Curcin V, Delaney BC, et al. The TRANSFoRm project: experience and lessons learned regarding functional and interoperability requirements to support primary care. Learn Heal Syst. 2018;2(2):1–7. Ethier JF, McGilchrist M, Barton A, Cloutier AM, Curcin V, Delaney BC, et al. The TRANSFoRm project: experience and lessons learned regarding functional and interoperability requirements to support primary care. Learn Heal Syst. 2018;2(2):1–7.
65.
go back to reference ROAD2H. Developing novel learning health system techniques to facilitate Universal Health Coverage (UHC) in low- and middle-income countries [Internet]. 2019 [cited 2019 Nov 15]. Available from: http://www.road2h.org/. ROAD2H. Developing novel learning health system techniques to facilitate Universal Health Coverage (UHC) in low- and middle-income countries [Internet]. 2019 [cited 2019 Nov 15]. Available from: http://​www.​road2h.​org/​.
67.
go back to reference Mastellos N, Bliźniuk G, Czopnik D, McGilchrist M, Misiaszek A, Bródka P, et al. Feasibility and acceptability of TRANSFoRm to improve clinical trial recruitment in primary care. Fam Pract. 2016;33(2):186–91.PubMedCrossRef Mastellos N, Bliźniuk G, Czopnik D, McGilchrist M, Misiaszek A, Bródka P, et al. Feasibility and acceptability of TRANSFoRm to improve clinical trial recruitment in primary care. Fam Pract. 2016;33(2):186–91.PubMedCrossRef
68.
go back to reference Saganowski S, Misiaszek A, Bródka P, Andreasson A, Curcin V, Delaney B, et al. TRANSFoRm eHealth solution for quality of life monitoring. AMIA Jt Summits Transl Sci proceedings AMIA Jt Summits Transl Sci. 2016;2016(247787):231–9. Saganowski S, Misiaszek A, Bródka P, Andreasson A, Curcin V, Delaney B, et al. TRANSFoRm eHealth solution for quality of life monitoring. AMIA Jt Summits Transl Sci proceedings AMIA Jt Summits Transl Sci. 2016;2016(247787):231–9.
70.
go back to reference Tomek I, Sabel A, Froimson M, Koenig K, Lewallen D, Naessens J, et al. A collaborative of leading health systems finds wide variations in total knee replacement delivery and takes steps to improve value. Health Aff. 2012;31(6):1–19.CrossRef Tomek I, Sabel A, Froimson M, Koenig K, Lewallen D, Naessens J, et al. A collaborative of leading health systems finds wide variations in total knee replacement delivery and takes steps to improve value. Health Aff. 2012;31(6):1–19.CrossRef
72.
go back to reference Wallace PJ, Shah ND, Dennen T, Bleicher PA, Crown WH. Optum labs: building a novel node in the learning health care system. Health Aff. 2014;33(7):1187–94.CrossRef Wallace PJ, Shah ND, Dennen T, Bleicher PA, Crown WH. Optum labs: building a novel node in the learning health care system. Health Aff. 2014;33(7):1187–94.CrossRef
75.
go back to reference Psek W, Davis FD, Gerrity G, Stametz R, Bailey-Davis L, Henninger D, et al. Leadership perspectives on operationalizing the learning health care system in an integrated delivery system. eGEMs. 2016;4(3):6.CrossRef Psek W, Davis FD, Gerrity G, Stametz R, Bailey-Davis L, Henninger D, et al. Leadership perspectives on operationalizing the learning health care system in an integrated delivery system. eGEMs. 2016;4(3):6.CrossRef
76.
go back to reference Fleurence RL, Curtis LH, Califf RM, Platt R, Selby JV, Brown JS. Launching PCORnet, a national patient-centered clinical research network. J Am Med Informatics Assoc. 2014;21(4):578–82.CrossRef Fleurence RL, Curtis LH, Califf RM, Platt R, Selby JV, Brown JS. Launching PCORnet, a national patient-centered clinical research network. J Am Med Informatics Assoc. 2014;21(4):578–82.CrossRef
78.
go back to reference Knighton AJ, Savitz L, Belnap T, Stephenson B, VanDerslice J. Introduction of an area deprivation index measuring patient socio-economic status in an integrated health system: implications for population health. eGEMs. 2016;4(3):9.CrossRef Knighton AJ, Savitz L, Belnap T, Stephenson B, VanDerslice J. Introduction of an area deprivation index measuring patient socio-economic status in an integrated health system: implications for population health. eGEMs. 2016;4(3):9.CrossRef
81.
go back to reference Califf RM. The patient-centered outcomes research network. N C Med J. 2014;75(3):204–10.PubMed Califf RM. The patient-centered outcomes research network. N C Med J. 2014;75(3):204–10.PubMed
Metadata
Title
Learning health systems in primary care: a systematic scoping review
Authors
Danielle M. Nash
Zohra Bhimani
Jennifer Rayner
Merrick Zwarenstein
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Care
Published in
BMC Primary Care / Issue 1/2021
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/s12875-021-01483-z

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