Skip to main content
Top
Published in: BMC Primary Care 1/2017

Open Access 01-12-2017 | Research article

How to choose the most appropriate cognitive test to evaluate cognitive complaints in primary care

Authors: Jolien Janssen, Paula S. Koekkoek, Eric P. Moll van Charante, L. Jaap Kappelle, Geert Jan Biessels, Guy E. H. M. Rutten

Published in: BMC Primary Care | Issue 1/2017

Login to get access

Abstract

Background

Despite the wealth of research devoted to the performance of individual cognitive tests for diagnosing cognitive impairment (including mild cognitive impairment and dementia), it can be difficult for general practitioners to choose the most appropriate test for a patient with cognitive complaints in daily practice.
In this paper we present a diagnostic algorithm for the evaluation of cognitive complaints in primary care. The rationale behind this algorithm is that the likelihood of cognitive impairment -which can be determined after history taking and an informant interview- should determine which cognitive test is most suitable.

Methods

We distinguished three likelihoods of cognitive impairment: not likely, possible or likely. We selected cognitive tests based on pre-defined required test features for each of these three situations and a review of the literature. We incorporated the cognitive tests in a practical diagnostic algorithm.

Results

Based on the available literature, in patients with complaints but where cognitive impairment is considered to be unlikely the clock-drawing test can be used to rule out cognitive impairment. When cognitive impairment is possible the Montreal cognitive assessment can be used to rule out cognitive impairment or to make cognitive impairment more likely. When cognitive impairment is likely the Mini-Mental State Examination can be used to confirm the presence of cognitive impairment.

Conclusions

We propose a diagnostic algorithm to increase the efficiency of ruling out or diagnosing cognitive impairment in primary care. Further study is needed to validate and evaluate this stepwise diagnostic algorithm.
Literature
1.
go back to reference Bradford A, Kunik ME, Schulz P, Williams SP, Singh H. Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors. Alzheimer Dis Assoc Disord. 2009;23:306–14.CrossRefPubMedPubMedCentral Bradford A, Kunik ME, Schulz P, Williams SP, Singh H. Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors. Alzheimer Dis Assoc Disord. 2009;23:306–14.CrossRefPubMedPubMedCentral
2.
go back to reference Olazarán J, Torrero P, Cruz I, Aparicio E, Sanz A, Mula N, et al. Mild cognitive impairment and dementia in primary care: the value of medical history. Fam Pract. 2011;28:385–92.CrossRefPubMed Olazarán J, Torrero P, Cruz I, Aparicio E, Sanz A, Mula N, et al. Mild cognitive impairment and dementia in primary care: the value of medical history. Fam Pract. 2011;28:385–92.CrossRefPubMed
3.
go back to reference Grobbee D, Hoes A. Clinical epidemiology: principles, methods, and applications for clinical research. London: Jones and Bartlett; 2014. Grobbee D, Hoes A. Clinical epidemiology: principles, methods, and applications for clinical research. London: Jones and Bartlett; 2014.
4.
go back to reference van den Dungen P, Moll van Charante EP, van de Ven PM, et al. Dutch family physicians' awareness of cognitive impairment among the elderly. BMC Geriatr. 2015;15:105.CrossRefPubMedPubMedCentral van den Dungen P, Moll van Charante EP, van de Ven PM, et al. Dutch family physicians' awareness of cognitive impairment among the elderly. BMC Geriatr. 2015;15:105.CrossRefPubMedPubMedCentral
5.
go back to reference Brodaty H, Low LF, Gibson L, Burns K. What is the best dementia screening instrument for general practitioners to use? Am J Geriatr Psychiatry. 2006;14:391–400.CrossRefPubMed Brodaty H, Low LF, Gibson L, Burns K. What is the best dementia screening instrument for general practitioners to use? Am J Geriatr Psychiatry. 2006;14:391–400.CrossRefPubMed
6.
go back to reference Cullen B, O'Neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatry. 2007;78:790–9.CrossRefPubMed Cullen B, O'Neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatry. 2007;78:790–9.CrossRefPubMed
7.
go back to reference Harvan JR, Cotter V. An evaluation of dementia screening in the primary care setting. J Am Acad Nurse Pract. 2006;18:351–60.CrossRefPubMed Harvan JR, Cotter V. An evaluation of dementia screening in the primary care setting. J Am Acad Nurse Pract. 2006;18:351–60.CrossRefPubMed
8.
go back to reference Ismail Z, Rajji TK, Shulman KI. Brief cognitive screening instruments: an update. Int J Geriatr Psychiatry. 2010;25:111–20.CrossRefPubMed Ismail Z, Rajji TK, Shulman KI. Brief cognitive screening instruments: an update. Int J Geriatr Psychiatry. 2010;25:111–20.CrossRefPubMed
12.
go back to reference Milne A, Culverwell A, Guss R, Tuppen J, Whelton R. Screening for dementia in primary care: a review of the use, efficacy and quality of measures. Int Psychogeriatr. 2008;20:911–26.CrossRefPubMed Milne A, Culverwell A, Guss R, Tuppen J, Whelton R. Screening for dementia in primary care: a review of the use, efficacy and quality of measures. Int Psychogeriatr. 2008;20:911–26.CrossRefPubMed
13.
go back to reference Mitchell AJ, Malladi S. Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. Am J Geriatr Psychiatry. 2010;18:759–82.CrossRefPubMed Mitchell AJ, Malladi S. Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. Am J Geriatr Psychiatry. 2010;18:759–82.CrossRefPubMed
14.
go back to reference Mitchell AJ, Malladi S. Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain tests. Am J Geriatr Psychiatry. 2010;18:783–800.CrossRefPubMed Mitchell AJ, Malladi S. Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain tests. Am J Geriatr Psychiatry. 2010;18:783–800.CrossRefPubMed
15.
go back to reference Woodford HJ, George J. Cognitive assessment in the elderly: a review of clinical methods. QJM. 2007;100:469–84.CrossRefPubMed Woodford HJ, George J. Cognitive assessment in the elderly: a review of clinical methods. QJM. 2007;100:469–84.CrossRefPubMed
17.
go back to reference Lin J, O'Connor E, Rossom R, Perdue L, Burda B, Thompson M, et al. Screening for Cognitive Impairment in Older Adults: An Evidence Update for the U.S. Preventive Services Task Force. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Nov. (Evidence Syntheses, No. 107.) https://www.ncbi.nlm.nih.gov/books/NBK174643/. Accessed 10 August 2017. Lin J, O'Connor E, Rossom R, Perdue L, Burda B, Thompson M, et al. Screening for Cognitive Impairment in Older Adults: An Evidence Update for the U.S. Preventive Services Task Force. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Nov. (Evidence Syntheses, No. 107.) https://​www.​ncbi.​nlm.​nih.​gov/​books/​NBK174643/​. Accessed 10 August 2017.
18.
go back to reference Shulman KI. Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry. 2000;15:548–61.CrossRefPubMed Shulman KI. Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry. 2000;15:548–61.CrossRefPubMed
19.
go back to reference Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.CrossRefPubMed Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.CrossRefPubMed
20.
go back to reference Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res. 1975;12:189–98.CrossRef Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res. 1975;12:189–98.CrossRef
21.
go back to reference Moll van Charante EP. Dementia guideline of the Dutch College of General Practitioners. Huisarts Wet. 2012;55:306–17. Moll van Charante EP. Dementia guideline of the Dutch College of General Practitioners. Huisarts Wet. 2012;55:306–17.
22.
go back to reference Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part I. Assessment Am Fam Physician. 2002;65(11):2263–72.PubMed Cummings JL, Frank JC, Cherry D, et al. Guidelines for managing Alzheimer's disease: part I. Assessment Am Fam Physician. 2002;65(11):2263–72.PubMed
23.
go back to reference Galvin JE, Sadowsky CH. Practical guidelines for the recognition and diagnosis of dementia. J Am Board Fam Med. 2012;25:367–82.CrossRefPubMed Galvin JE, Sadowsky CH. Practical guidelines for the recognition and diagnosis of dementia. J Am Board Fam Med. 2012;25:367–82.CrossRefPubMed
24.
go back to reference Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatry Clin Neurosci. 2000;12:233–9.CrossRefPubMed Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory. J Neuropsychiatry Clin Neurosci. 2000;12:233–9.CrossRefPubMed
26.
go back to reference Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17:37–49.CrossRefPubMed Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17:37–49.CrossRefPubMed
27.
go back to reference Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9:63–75.CrossRefPubMed Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9:63–75.CrossRefPubMed
28.
go back to reference Meng X, D'Arcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One. 2012;7:e38268.CrossRefPubMedPubMedCentral Meng X, D'Arcy C. Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One. 2012;7:e38268.CrossRefPubMedPubMedCentral
30.
go back to reference Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA. Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014;10:562–70.CrossRefPubMed Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA. Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014;10:562–70.CrossRefPubMed
31.
go back to reference Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med. 2004;256:240–6.CrossRefPubMed Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med. 2004;256:240–6.CrossRefPubMed
32.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000.
34.
35.
go back to reference Adelman AM, Daly MP. Initial evaluation of the patient with suspected dementia. Am Fam Physician. 2005;71(9):1745–50.PubMed Adelman AM, Daly MP. Initial evaluation of the patient with suspected dementia. Am Fam Physician. 2005;71(9):1745–50.PubMed
36.
go back to reference Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, et al. Diagnosis and treatment of dementia: 2. Diagnosis CMAJ. 2008;178:825–36.CrossRefPubMed Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, et al. Diagnosis and treatment of dementia: 2. Diagnosis CMAJ. 2008;178:825–36.CrossRefPubMed
37.
go back to reference Geldmacher DS, Kerwin DR. Practical diagnosis and Management of Dementia due to Alzheimer's disease in the primary care setting: an evidence-based approach. Prim Care Companion CNS Disord. 2013;15 Geldmacher DS, Kerwin DR. Practical diagnosis and Management of Dementia due to Alzheimer's disease in the primary care setting: an evidence-based approach. Prim Care Companion CNS Disord. 2013;15
38.
go back to reference Lee L, Weston WW, Heckman G, Gagnon M, Lee FJ, Sloka S. Structured approach to patients with memory difficulties in family practice. Can Fam Physician. 2013;59(3):249–54.PubMedPubMedCentral Lee L, Weston WW, Heckman G, Gagnon M, Lee FJ, Sloka S. Structured approach to patients with memory difficulties in family practice. Can Fam Physician. 2013;59(3):249–54.PubMedPubMedCentral
40.
go back to reference Dyer SM, Laver K, Pond CD, Cumming RG, Whitehead C, Crotty M. Clinical practice guidelines and principles of care for people with dementia in Australia. Aust Fam Physician. 2016;45(12):884–9.PubMed Dyer SM, Laver K, Pond CD, Cumming RG, Whitehead C, Crotty M. Clinical practice guidelines and principles of care for people with dementia in Australia. Aust Fam Physician. 2016;45(12):884–9.PubMed
Metadata
Title
How to choose the most appropriate cognitive test to evaluate cognitive complaints in primary care
Authors
Jolien Janssen
Paula S. Koekkoek
Eric P. Moll van Charante
L. Jaap Kappelle
Geert Jan Biessels
Guy E. H. M. Rutten
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Primary Care / Issue 1/2017
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/s12875-017-0675-4

Other articles of this Issue 1/2017

BMC Primary Care 1/2017 Go to the issue