Skip to main content
Top
Published in: BMC Anesthesiology 1/2017

Open Access 01-12-2017 | Case report

Acute transient spinal paralysis and cardiac symptoms following an accidental epidural potassium infusion – a case report

Authors: Martin Kreutzträger, Marcel A. Kopp, Thomas Liebscher

Published in: BMC Anesthesiology | Issue 1/2017

Login to get access

Abstract

Background

To describe a case of an accidental epidural potassium infusion leading to an acute transient spinal paralysis and cardiac symptoms and review the literature on that topic.

Case presentation

We report the case of an accidental infusion of 900 mg potassium chloride 7.45% (KCl) into the epidural space, which occurred during epidural analgesia in a 74-year-old patient suffering from immobilization due to lumbar back pain as well as from a paralytic Ileus. The event was resulting in vegetative symptoms, such as tachycardia and hypertension accompanied by a motor complete tetraplegia (AIS B) sub C2 with respiratory depression. The endotracheal intubation was necessary.
The patient was treated with 40 mg dexamethasone intravenously, as well an epidural lavage with sodium chloride solution 0.9% (NaCl) through the epidural catheter. The neurologic symptoms completely resolved within five days. An elevation of troponin-T values and a reduced left ventricular ejection fraction (LVEF) of 40% accompanied by transient pectanginous pain were documented. An exertional dyspnea remained.

Conclusions

A symptom complex with elevated sympathetic nervous system activity up to a stress cardiomyopathy is possible following epidural potassium infusion. Additionally, generalized pain and muscle spasticity evolve and a progressive acute spinal cord injury syndrome can occur within minutes, accompanied by respiratory depression. Treatment consists of early intensive care and the symptomatic therapy of the associated symptoms, leading in most of the reported cases to a good clinical outcome.
Literature
1.
go back to reference Martin J, et al. Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey. In: Critical …; 2007. Martin J, et al. Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey. In: Critical …; 2007.
2.
go back to reference Jorgensen, H., et al., Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery The Cochrane database of systematic reviews, 2000(4): p. CD001893. Jorgensen, H., et al., Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery The Cochrane database of systematic reviews, 2000(4): p. CD001893.
3.
go back to reference Ballantyne JC, et al. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg. 1998;86(3):598–612.CrossRefPubMed Ballantyne JC, et al. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg. 1998;86(3):598–612.CrossRefPubMed
4.
go back to reference Popping, D.M., et al., Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Archives of surgery (Chicago, Ill. : 1960), 2008. 143(10): p. 990–9- discussion 1000. Popping, D.M., et al., Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Archives of surgery (Chicago, Ill. : 1960), 2008. 143(10): p. 990–9- discussion 1000.
5.
go back to reference Baron, R., et al., Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. German medical science : GMS e-journal, 2015. 13: p. Doc19. Baron, R., et al., Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. German medical science : GMS e-journal, 2015. 13: p. Doc19.
6.
go back to reference Charlson ME, Pompei P, Ales KL. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. In: Journal of chronic …; 1987. Charlson ME, Pompei P, Ales KL. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. In: Journal of chronic …; 1987.
7.
go back to reference Dias J, et al. Accidental spinal potassium chloride injection successfully treated with spinal lavage. Anaesthesia. 2013;69(1):72–6.CrossRefPubMed Dias J, et al. Accidental spinal potassium chloride injection successfully treated with spinal lavage. Anaesthesia. 2013;69(1):72–6.CrossRefPubMed
8.
go back to reference Hew CM, Cyna AM. Avoiding inadvertent epidural injection of drugs intended for non-epidural use. In: … and intensive care; 2003. Hew CM, Cyna AM. Avoiding inadvertent epidural injection of drugs intended for non-epidural use. In: … and intensive care; 2003.
9.
go back to reference Kulka PJ, et al. Versehentliche Infusion von Kaliumchlorid in einen Epiduralkatheter. Anaesthesist. 1999;48(12):896–9.CrossRefPubMed Kulka PJ, et al. Versehentliche Infusion von Kaliumchlorid in einen Epiduralkatheter. Anaesthesist. 1999;48(12):896–9.CrossRefPubMed
10.
go back to reference Lin D, Becker K, Shapiro HM. Neurologic changes following epidural injection of potassium chloride and diazepam: a case report with laboratory correlations. Anesthesiology. 1986; Lin D, Becker K, Shapiro HM. Neurologic changes following epidural injection of potassium chloride and diazepam: a case report with laboratory correlations. Anesthesiology. 1986;
11.
go back to reference Litz RJ, et al. Inadvertent infusion of a high dose of potassium chloride via a thoracic epidural catheter. Eur J Anaesthesiol. 2001;18(10):697–9.CrossRefPubMed Litz RJ, et al. Inadvertent infusion of a high dose of potassium chloride via a thoracic epidural catheter. Eur J Anaesthesiol. 2001;18(10):697–9.CrossRefPubMed
12.
go back to reference Parodi G, Antoniucci D. Transient left ventricular apical ballooning syndrome after inadvertent epidural administration of potassium chloride. Int J Cardiol. 2008;124(1):e14–5.CrossRefPubMed Parodi G, Antoniucci D. Transient left ventricular apical ballooning syndrome after inadvertent epidural administration of potassium chloride. Int J Cardiol. 2008;124(1):e14–5.CrossRefPubMed
13.
go back to reference Peduto VA, Mezzetti D, Gori F. A clinical diagnosis of inadvertent epidural administration of potassium chloride. In: European journal of …; 1999. Peduto VA, Mezzetti D, Gori F. A clinical diagnosis of inadvertent epidural administration of potassium chloride. In: European journal of …; 1999.
14.
go back to reference Shanker KB, Palkar NV, Nishkala R. Paraplegia following epidural potassium chloride. Anaesthesia. 1985;40(1):45–7.CrossRefPubMed Shanker KB, Palkar NV, Nishkala R. Paraplegia following epidural potassium chloride. Anaesthesia. 1985;40(1):45–7.CrossRefPubMed
15.
go back to reference Tessler MJ, White I, Nauger-Colville MA. Inadvertent Epidural Administration of Potassium Chloride A Case Report. Obstetric. Anesthesia. 1989; Tessler MJ, White I, Nauger-Colville MA. Inadvertent Epidural Administration of Potassium Chloride A Case Report. Obstetric. Anesthesia. 1989;
16.
go back to reference van der Steeg HJ, et al. Inadvertent infusion of potassium chloride via an epidural catheter. Acta Anaesthesiol Belg. 2007;58(3):191–5.PubMed van der Steeg HJ, et al. Inadvertent infusion of potassium chloride via an epidural catheter. Acta Anaesthesiol Belg. 2007;58(3):191–5.PubMed
18.
go back to reference Liu K, Chia YY. Inadvertent epidural injection of potassium chloride. Report of two cases. Acta Anaesthesiol Scand. 1995;39(8):1134–7.CrossRefPubMed Liu K, Chia YY. Inadvertent epidural injection of potassium chloride. Report of two cases. Acta Anaesthesiol Scand. 1995;39(8):1134–7.CrossRefPubMed
Metadata
Title
Acute transient spinal paralysis and cardiac symptoms following an accidental epidural potassium infusion – a case report
Authors
Martin Kreutzträger
Marcel A. Kopp
Thomas Liebscher
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2017
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-017-0425-0

Other articles of this Issue 1/2017

BMC Anesthesiology 1/2017 Go to the issue