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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2018 | Original research

Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome

Authors: Lorraine M. Provencher, Aaron M. Fairbanks, Michael D. Abramoff, Nasreen A. Syed

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2018

Abstract

Background

Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU.

Methods

Retrospective observational case series of nine patients with TINU and ≥ 30 days follow-up. Presenting symptoms, visual acuity, uveitis characteristics, follow-up, Uβ2M, serum creatinine (SCr), urinalysis, and renal biopsy results were collected.

Results

A correlation between Uβ2M and anterior chamber (AC) cell (r = 0.69, 95% CI 0.46–0.84), flare (r = 0.65, 95% CI 0.39–0.81), trended toward a stronger correlation than SCr and AC cell (r = 0.59, 95% CI 0.29–0.79), flare (r = 0.52, 95% CI 0.19–0.75). Uβ2M decreased over 1–2 years while SCr returned to normal within a few months.

Conclusions

Uβ2M correlate with uveitis activity and trend down over the course of TINU. Uβ2M may serve as a useful tool in determining where patients are in their systemic disease course.

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Title: Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome
Authors: Lorraine M. Provencher
Aaron M. Fairbanks
Michael D. Abramoff
Nasreen A. Syed
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2018
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/s12348-018-0166-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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