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Journal of Ophthalmic Inflammation and Infection
Published in: Journal of Ophthalmic Inflammation and Infection 1/2016

Open Access 01-12-2016 | Letter to the Editor

Bilateral acute retinal necrosis in a patient with multiple sclerosis on natalizumab

Authors: Arjun B. Sood, Gokul Kumar, Joshua Robinson

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2016

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Abstract

Purpose

The purpose of this study is to report a case of bilateral acute retinal necrosis in a patient with multiple sclerosis treated with natalizumab.

Methods

This study is a case report and literature review.

Results

A 34-year-old Caucasian female with multiple sclerosis presented with 1 week of blurry vision in both eyes during treatment with natalizumab. Clinical examination revealed bilateral acute retinal necrosis. The patient was treated with systemic intravenous acyclovir and intravitreal injections foscarnet and ganciclovir. Natalizumab therapy was also discontinued.

Conclusions

Natalizumab is a potent immunosuppressive agent used in relapsing remitting multiple sclerosis and Crohn’s disease. The use of this medication is commonly associated with opportunistic infections in the CNS. In rare cases, ocular opportunistic infections may occur and can lead to significant visual impairment and blindness. Neurologists and ophthalmologists should be aware of this potential complication.
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Metadata
Title
Bilateral acute retinal necrosis in a patient with multiple sclerosis on natalizumab
Authors
Arjun B. Sood
Gokul Kumar
Joshua Robinson
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Journal of Ophthalmic Inflammation and Infection / Issue 1/2016
Electronic ISSN: 1869-5760
DOI
https://doi.org/10.1186/s12348-016-0095-y

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