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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2016 | Brief report

Bilateral frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome

Authors: Edward H. Wood, Robert W. Wong

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2016

Abstract

Background

“Frosted branch retinal angiitis” is an encompassing term for a rare, typically bilateral diffuse retinal periphlebitis that may occur in a number of varying conditions. To our knowledge, we report the first case of frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome in a 28-year-old woman.

Findings

This study is a retrospective case report and literature review. Serial fundus photos, fluorescein angiogram, and ocular coherence tomography taken were before and after treatment, showing resolution of diffuse retinal perivascular sheathing and macular edema along with marked improvement in visual acuity 4 months after the treatment with corticosteroids.

Conclusions

Frosted branch angiitis can be seen in association with antiphospholipid antibody syndrome. Prompt recognition and treatment with corticosteroids may result in good visual prognosis, and long-term immunosuppression and additional anticoagulation may be beneficial to prevent recurrence.

Ito Y, Nakano M, Kyu N, Takeuchi M (1976) Frosted branch angiitis in a child. Jpn J Clin Ophthalmol 30:797–803

Hernandez-Da Mota SE, Arellanes-Garcia L, Recillas-Gispert C et al (2011) Lupus relapse presented as frosted branch retinal angiitis: case report. Ocul Immunol Inflamm 19:367–369. doi:10.3109/09273948.2011.603879 CrossRefPubMed

Quillen DA, Stathopoulos NA, Blankenship GW, Ferriss JA (1997) Lupus associated frosted branch periphlebitis and exudative maculopathy. Retina 17:449–451CrossRefPubMed

Kwon SJ, Park DH, Shin JP (2013) Frosted branch angiitis as ocular manifestation of Behcet’s disease: unusual case report and literature review. Korean J Ophthalmol 27:466–469. doi:10.3341/kjo.2013.27.6.466 CrossRefPubMedPubMedCentral

Sykes SO, Horton JC (1997) Steroid-responsive retinal vasculitis with a frosted branch appearance in Crohns disease. Retina 17:451–454CrossRefPubMed

Spaide RF, Vitale AT, Toth IR, Oliver JM (1992) Frosted branch angiitis associated with cytomegalovirus retinitis. Am J Ophthalmol 113:522–528CrossRefPubMed

Markomichelakis NN, Barampouti F, Zafirakis P et al (1999) Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2. Retina 19:455–457CrossRefPubMed

Zhao H, Guan J, Zhou L et al (2012) Frosted branch angiitis in a woman with Mycobacterium tuberculosis infection. Ocul Immunol Inflamm 20:227–229. doi:10.3109/09273948.2012.673044 CrossRefPubMed

Suzuki T, Onouchi H, Nakagawa Y et al (2010) A case of recurrence of congenital ocular toxoplasmosis with frosted branch angiitis (ocular toxoplasmosis with frosted branch angiitis). Tokai J Exp Clin Med 35:122–125PubMed

10.

Walker S, Iguchi A, Jones NP (2004) Frosted branch angiitis: a review. Eye 18:527–533. doi:10.1038/sj.eye.6700712 CrossRefPubMed

11.

Matsui Y, Tsukitome H, Uchiyama E et al (2013) Peripheral capillary nonperfusion and full-field electroretinographic changes in eyes with frosted branch-like appearance retinal vasculitis. Clin Ophthalmol 7:137–140. doi:10.2147/OPTH.S40110 PubMedPubMedCentral

12.

Kim TS, Duker JS, Hedges TR (1994) Retinal angiopathy resembling unilateral frosted branch angiitis in a patient with relapsing acute lymphoblastic leukemia. Am J Ophthalmol 117:806–808CrossRefPubMed

13.

Hua MT, Blaise P, De Leval L, Rakic JM (2009) Frosted branch angiitis with undiagnosed Hodgkin lymphoma. Eur J Ophthalmol 19:310–313PubMed

14.

Wong R, Cunningham E (2013) Posterior segment findings in SLE. Rev Ophthalmol 20:41–45

15.

Mehdi AA, Uthman I, Khamashta M (2010) Antiphospholipid syndrome: pathogenesis and a window of treatment opportunities in the future. Eur J Clin Invest 40:451–464. doi:10.1111/j.1365-2362.2010.02281.x CrossRefPubMed

16.

Saigal R, Kansal A, Mittal M et al (2010) Antiphospholipid antibody syndrome. J Assoc Physicians India 58:176–184PubMed

17.

Utz VM, Tang J (2011) Ocular manifestations of the antiphospholipid syndrome. Br J Ophthalmol 95:454–459. doi:10.1136/bjo.2010.182857 CrossRefPubMed

18.

Petri M (2005) Review of classification criteria for systemic lupus erythematosus. Rheum Dis Clin North Am 31:245–254. doi:10.1016/j.rdc.2005.01.009 CrossRefPubMed

19.

Gomez-Puerta JA, Martin H, Amigo MC et al (2005) Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus? Medicine 84:225–230CrossRefPubMed

20.

Montehermoso A, Cervera R, Font J et al (1999) Association of antiphospholipid antibodies with retinal vascular disease in systemic lupus erythematosus. Semin Arthritis Rheum 28:326–332CrossRefPubMed

21.

Au A, O’Day J (2004) Review of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphospholipid syndrome: associations, visual outcomes, complications and treatment. Clin Exp Ophthalmol 32:87–100CrossRef

22.

Abu El-Asrar AM, Al-Obeidan SA, Abdel Gader AG (2003) Retinal periphlebitis resembling frosted branch angiitis with nonperfused central retinal vein occlusion. Eur J Ophthalmol 13:807–812PubMed

23.

Petri M (2011) Use of hydroxychloroquine to prevent thrombosis in systemic lupus erythematosus and in antiphospholipid antibody-positive patients. Curr Rheumatol Rep 13:77–80. doi:10.1007/s11926-010-0141-y CrossRefPubMed

24.

Tett SE, Cutler DJ, Day RO, Brown KF (1989) Bioavailability of hydroxychloroquine tablets in healthy volunteers. Br J Clin Pharmacol 27:771–779CrossRefPubMedPubMedCentral

Title: Bilateral frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome
Authors: Edward H. Wood
Robert W. Wong
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2016
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/s12348-016-0089-9

At a glance: The STEP trials

Springer Medicine

Bilateral frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome

Abstract

Background

Findings

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Findings

Conclusions

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