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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2014 | Original research

Variation of choroidal thickness and vessel diameter in patients with posterior non-infectious uveitis

Authors: Millena G Bittencourt, Saleema Kherani, Daniel A Ferraz, Mehreen Ansari, Humzah Nasir, Yasir J Sepah, Mostafa Hanout, Diana V Do, Quan Dong Nguyen

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2014

Abstract

Background

Choroidal thickness (CTh) and choroidal vessel diameter (VD) in the Haler’s layer were evaluated as markers of inflammatory insult in non-infectious uveitis (NIU). Spectral-domain optical coherence tomography (Spectralis®, Heidelberg Engineering Inc.) scans were acquired from 23 normal subjects (39 eyes – group 1), 7 subjects with high myopia (14 eyes – group 2), and 19 patients with NIU (23 eyes – group 3). In groups 1 and 2, CTh and VD were measured at 3 different points of the same horizontal OCT scan passing through the fovea and a mean calculated. Mean CTh and VD were calculated in 2 other locations, 2 mm superior and inferior from the chosen foveal horizontal scan. In group 3, three measurements of CTh and VD were obtained within 1 mm of a horizontal scan passing through a retinal lesion; mean CTh and VD were then computed. A ratio (R) between the VD and the corresponding CTh was calculated.

Results

Group 1, 2 and 3 mean age was 29.6, 29.1 and 45.9 years, respectively. Sixteen normal subjects, three myopic subjects and six NIU patients were male.. Group 1 mean CTh did not differ from group 2 (261.6±45.6 vs. 260.2±50.6 µm µm; p>0.05); mean VD was marginally higher in Group 2 (159.8±32.2 vs. 163.2±33.2 µm; p>0.05). Group 3 demonstrated thinner CTh (193.6±54.6 µm) than Groups 1 and 2 (p = 0.02 and <0.001). Group 3 mean VD (123.6±37.4 µm) was also less than that in Groups 1 and 2; the difference was statistically significant only when compared to group 2, p = 0.01. R did not differ across groups (p-values >0.05), indicating that variations in CTh and VD followed the same trend.

Conclusions

The study reports potential quantitative OCT-derived parameters that may be explored in future trials of non-infectious uveitis. Thinning of choroid and decrease of vessel diameter are observed in patients with chronic NIU compared to controls.

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Title: Variation of choroidal thickness and vessel diameter in patients with posterior non-infectious uveitis
Authors: Millena G Bittencourt
Saleema Kherani
Daniel A Ferraz
Mehreen Ansari
Humzah Nasir
Yasir J Sepah
Mostafa Hanout
Diana V Do
Quan Dong Nguyen
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2014
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/s12348-014-0014-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Variation of choroidal thickness and vessel diameter in patients with posterior non-infectious uveitis

Abstract

Background

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Results

Conclusions

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