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International Journal of Emergency Medicine

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Open Access 01-12-2021 | Naloxone | Case report

Pediatric tizanidine toxicity reversed with naloxone: a case report

Authors: Doaa Bader, Ahmed Adam, Mohamed Shaban, Bader Alyahya

Published in: International Journal of Emergency Medicine | Issue 1/2021

Abstract

Background

Tizanidine, an α-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone.

Case presentation

A 3-year-old male presented to the emergency department with lethargy, bradycardia, and bradypnea after accidental ingestion of multiple tizanidine tablets. Improvements in the level of consciousness and respiratory and heart rates were observed after two intravenous administrations of naloxone at a dose of 0.05 and 0.1 mg/kg, respectively.

Conclusions

This case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting α-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning.

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Title: Pediatric tizanidine toxicity reversed with naloxone: a case report
Authors: Doaa Bader
Ahmed Adam
Mohamed Shaban
Bader Alyahya
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Naloxone
Intoxication
Published in: International Journal of Emergency Medicine / Issue 1/2021
Print ISSN: 1865-1372
Electronic ISSN: 1865-1380
DOI: https://doi.org/10.1186/s12245-021-00397-y

At a glance: The STEP trials

Springer Medicine

Pediatric tizanidine toxicity reversed with naloxone: a case report

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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