Skip to main content
Top
Published in: International Journal of Emergency Medicine 1/2017

Open Access 01-12-2017 | Original Research

Risk factors for recurrent emergency department visits for hyperglycemia in patients with diabetes mellitus

Authors: Justin W. Yan, Katherine M. Gushulak, Melanie P. Columbus, Kristine van Aarsen, Alexandra L. Hamelin, George A. Wells, Ian G. Stiell

Published in: International Journal of Emergency Medicine | Issue 1/2017

Login to get access

Abstract

Background

Patients with poorly controlled diabetes mellitus may present repeatedly to the emergency department (ED) for management and treatment of hyperglycemic episodes, including diabetic ketoacidosis and hyperosmolar hyperglycemic state. The objective of this study was to identify risk factors that predict unplanned recurrent ED visits for hyperglycemia in patients with diabetes within 30 days of initial presentation.

Methods

We conducted a 1-year health records review of patients ≥18 years presenting to one of four tertiary care EDs with a discharge diagnosis of hyperglycemia, diabetic ketoacidosis, or hyperosmolar hyperglycemic state. Trained research personnel collected data on patient characteristics and determined if patients had an unplanned recurrent ED visit for hyperglycemia within 30 days of their initial presentation. Multivariate logistic regression models using generalized estimating equations to account for patients with multiple visits determined predictor variables independently associated with recurrent ED visits for hyperglycemia within 30 days.

Results

There were 833 ED visits for hyperglycemia in the 1-year period. 54.6% were male and mean (SD) age was 48.8 (19.5). Of all visitors, 156 (18.7%) had a recurrent ED visit for hyperglycemia within 30 days. Factors independently associated with recurrent hyperglycemia visits included a previous hyperglycemia visit in the past month (odds ratio [OR] 3.5, 95% confidence interval [CI] 2.1–5.8), age <25 years (OR 2.6, 95% CI 1.5–4.7), glucose >20 mmol/L (OR 2.2, 95% CI 1.3–3.7), having a family physician (OR 2.2, 95% CI 1.0–4.6), and being on insulin (OR 1.9, 95% CI 1.1–3.1). Having a systolic blood pressure between 90–150 mmHg (OR 0.53, 95% CI 0.30–0.93) and heart rate >110 bpm (OR 0.41, 95% CI 0.23–0.72) were protective factors independently associated with not having a recurrent hyperglycemia visit.

Conclusions

This unique ED-based study reports five risk factors and two protective factors associated with recurrent ED visits for hyperglycemia within 30 days in patients with diabetes. These risk factors should be considered by clinicians when making management, prognostic, and disposition decisions for diabetic patients who present with hyperglycemia.
Appendix
Available only for authorised users
Literature
1.
go back to reference National Hospital Ambulatory Medical Care Survey: 2010 Emergency Department Summary Tables. The Ambulatory and Hospital Care Statistics Branch, U.S. Bureau of the Census. National Hospital Ambulatory Medical Care Survey: 2010 Emergency Department Summary Tables. The Ambulatory and Hospital Care Statistics Branch, U.S. Bureau of the Census.
3.
go back to reference U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Available at http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Accessed 20 May 2016. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Available at http://​www.​cdc.​gov/​diabetes/​pubs/​pdf/​ndfs_​2011.​pdf.​ Accessed 20 May 2016.
4.
5.
go back to reference Bazargan M, Johnson KH, Stein JA. Emergency department utilization among Hispanic and African-American under-served patients with type 2 diabetes. Ethn Dis. 2003;13:369–75.PubMed Bazargan M, Johnson KH, Stein JA. Emergency department utilization among Hispanic and African-American under-served patients with type 2 diabetes. Ethn Dis. 2003;13:369–75.PubMed
6.
go back to reference Ford W, Self WH, Slovis C, McNaughton CD. Diabetes in the emergency department and hospital: acute care of diabetes patients. Curr Emerg Hosp Med Rep. 2013;1:1–9.CrossRefPubMedPubMedCentral Ford W, Self WH, Slovis C, McNaughton CD. Diabetes in the emergency department and hospital: acute care of diabetes patients. Curr Emerg Hosp Med Rep. 2013;1:1–9.CrossRefPubMedPubMedCentral
7.
go back to reference Alourfi Z, Homsi H. Precipitating factors, outcomes, and recurrence of diabetic ketoacidosis at a university hospital in Damascus. Avicenna J Med. 2015;5(1):11–5.CrossRefPubMedPubMedCentral Alourfi Z, Homsi H. Precipitating factors, outcomes, and recurrence of diabetic ketoacidosis at a university hospital in Damascus. Avicenna J Med. 2015;5(1):11–5.CrossRefPubMedPubMedCentral
8.
go back to reference Malone ML, Gennis V, Goodwin JS. Characteristics of diabetic ketoacidosis in older versus younger adults. J Am Geriatr Soc. 1992;40:1100–4.CrossRefPubMed Malone ML, Gennis V, Goodwin JS. Characteristics of diabetic ketoacidosis in older versus younger adults. J Am Geriatr Soc. 1992;40:1100–4.CrossRefPubMed
10.
go back to reference Hu KW, Lu YH, Lin HJ, et al. Unscheduled return visits with and without admission post emergency department discharge. J Emerg Med. 2012;43(6):1110–8.CrossRefPubMed Hu KW, Lu YH, Lin HJ, et al. Unscheduled return visits with and without admission post emergency department discharge. J Emerg Med. 2012;43(6):1110–8.CrossRefPubMed
11.
go back to reference Verelst S, Pierloot S, Desruelles D, et al. Short-term unscheduled return visits of adult patients to the emergency department. J Emerg Med. 2014;47(2):131–9.CrossRefPubMed Verelst S, Pierloot S, Desruelles D, et al. Short-term unscheduled return visits of adult patients to the emergency department. J Emerg Med. 2014;47(2):131–9.CrossRefPubMed
12.
go back to reference Ross MA, Hemphill RR, Abramson J, et al. The recidivism characteristics of an emergency department observation unit. Ann Emerg Med. 2010;56(1):34–41.CrossRefPubMed Ross MA, Hemphill RR, Abramson J, et al. The recidivism characteristics of an emergency department observation unit. Ann Emerg Med. 2010;56(1):34–41.CrossRefPubMed
13.
go back to reference Sauvin G, Freund Y, Saidi K, et al. Unscheduled return visits to the emergency department: consequences for triage. Acad Emerg Med. 2013;20(1):33–9.CrossRefPubMed Sauvin G, Freund Y, Saidi K, et al. Unscheduled return visits to the emergency department: consequences for triage. Acad Emerg Med. 2013;20(1):33–9.CrossRefPubMed
14.
go back to reference Sykes M, Pimentel M, Santos M, et al. Incidence of and risk factors for readmission to intensive care in primary diabetic ketoacidosis [abstract]. Intensive Care Med Conf: 27th Ann Congr Eur Soc Intensive Care Med. 40(1)S1:S150. Sykes M, Pimentel M, Santos M, et al. Incidence of and risk factors for readmission to intensive care in primary diabetic ketoacidosis [abstract]. Intensive Care Med Conf: 27th Ann Congr Eur Soc Intensive Care Med. 40(1)S1:S150.
15.
go back to reference Diggle PJ, Liang KY, Zeger SL. Analysis of longitudinal data. New York: Clarendon Press, Oxford; 1994. Diggle PJ, Liang KY, Zeger SL. Analysis of longitudinal data. New York: Clarendon Press, Oxford; 1994.
16.
go back to reference Homish GG, Leonard KE. The drinking partnership and marital satisfaction: the longitudinal influence of discrepant drinking. J Consult Clin Psychol. 2007;75(1):43–51.CrossRefPubMedPubMedCentral Homish GG, Leonard KE. The drinking partnership and marital satisfaction: the longitudinal influence of discrepant drinking. J Consult Clin Psychol. 2007;75(1):43–51.CrossRefPubMedPubMedCentral
17.
go back to reference Homish GG, Leonard KE, Cornelius JR. Predictors of marijuana use among married couples: the influence of one’s spouse. Drug Alcohol Depend. 2007;91(2-3):121–8.CrossRefPubMedPubMedCentral Homish GG, Leonard KE, Cornelius JR. Predictors of marijuana use among married couples: the influence of one’s spouse. Drug Alcohol Depend. 2007;91(2-3):121–8.CrossRefPubMedPubMedCentral
18.
go back to reference Zeger SL, Liang KY. An overview of methods for the analysis of longitudinal data. Stat Med. 1992;11(14-15):1825–39.CrossRefPubMed Zeger SL, Liang KY. An overview of methods for the analysis of longitudinal data. Stat Med. 1992;11(14-15):1825–39.CrossRefPubMed
19.
go back to reference Liang KY, Zeger SL. Regression analysis for correlated data. Annu Rev Public Health. 1993;14:43–68.CrossRefPubMed Liang KY, Zeger SL. Regression analysis for correlated data. Annu Rev Public Health. 1993;14:43–68.CrossRefPubMed
20.
go back to reference Zeger SL, Liang KY, Albert PS. Models for longitudinal data: a generalized estimating equation approach. Biometrics. 1988;44(4):1049–60.CrossRefPubMed Zeger SL, Liang KY, Albert PS. Models for longitudinal data: a generalized estimating equation approach. Biometrics. 1988;44(4):1049–60.CrossRefPubMed
21.
go back to reference Driver BE, Olives TD, Bischof JE, et al. Discharge glucose levels and amount of glucose reduction are not associated with short-term adverse outcomes in discharged patients with type 2 diabetes with severe hyperglycemia [abstract]. Acad Emerg Med. 2013;20(5)S1:S185-S186. Driver BE, Olives TD, Bischof JE, et al. Discharge glucose levels and amount of glucose reduction are not associated with short-term adverse outcomes in discharged patients with type 2 diabetes with severe hyperglycemia [abstract]. Acad Emerg Med. 2013;20(5)S1:S185-S186.
22.
go back to reference Rowe BH, Villa-Roel C, Sivilotti M, et al. Relapse after emergency department discharge for acute asthma. Acad Emerg Med. 2008;15:709–17.CrossRefPubMed Rowe BH, Villa-Roel C, Sivilotti M, et al. Relapse after emergency department discharge for acute asthma. Acad Emerg Med. 2008;15:709–17.CrossRefPubMed
23.
go back to reference Home P, Riddle M, Cefalu WT, et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes Care. 2014;37(6):1499–508.CrossRefPubMedPubMedCentral Home P, Riddle M, Cefalu WT, et al. Insulin therapy in people with type 2 diabetes: opportunities and challenges? Diabetes Care. 2014;37(6):1499–508.CrossRefPubMedPubMedCentral
24.
go back to reference Hernandez AF, Greiner MA, Fonarow GC, et al. Relationship between early physician follow-up and 30-day readmission among medicare beneficiaries hospitalized for heart failure. JAMA. 2010;303(17):1716–22.CrossRefPubMed Hernandez AF, Greiner MA, Fonarow GC, et al. Relationship between early physician follow-up and 30-day readmission among medicare beneficiaries hospitalized for heart failure. JAMA. 2010;303(17):1716–22.CrossRefPubMed
25.
go back to reference Sharma G, Kuo Y, Freeman JL, et al. Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Arch Intern Med. 2010;170(18):1664–70.CrossRefPubMedPubMedCentral Sharma G, Kuo Y, Freeman JL, et al. Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Arch Intern Med. 2010;170(18):1664–70.CrossRefPubMedPubMedCentral
26.
go back to reference Howard MS, Davis BA, Anderson C, et al. Patients’ perspective on choosing the emergency department for nonurgent medical care: a qualitative study exploring one reason for overcrowding. J Emerg Nurs. 2005;31(5):429–35.CrossRefPubMed Howard MS, Davis BA, Anderson C, et al. Patients’ perspective on choosing the emergency department for nonurgent medical care: a qualitative study exploring one reason for overcrowding. J Emerg Nurs. 2005;31(5):429–35.CrossRefPubMed
27.
go back to reference McCusker J, Karp I, Cardin S, et al. Determinants of emergency department visits by older adults: a systematic review. Acad Emerg Med. 2003;10(12):1362–70.CrossRefPubMed McCusker J, Karp I, Cardin S, et al. Determinants of emergency department visits by older adults: a systematic review. Acad Emerg Med. 2003;10(12):1362–70.CrossRefPubMed
Metadata
Title
Risk factors for recurrent emergency department visits for hyperglycemia in patients with diabetes mellitus
Authors
Justin W. Yan
Katherine M. Gushulak
Melanie P. Columbus
Kristine van Aarsen
Alexandra L. Hamelin
George A. Wells
Ian G. Stiell
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Emergency Medicine / Issue 1/2017
Print ISSN: 1865-1372
Electronic ISSN: 1865-1380
DOI
https://doi.org/10.1186/s12245-017-0150-y

Other articles of this Issue 1/2017

International Journal of Emergency Medicine 1/2017 Go to the issue