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Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 1/2018

Open Access 01-12-2018 | Research article

Association between diabetes and pesticides: a case-control study among Thai farmers

Authors: Chudchawal Juntarawijit, Yuwayong Juntarawijit

Published in: Environmental Health and Preventive Medicine | Issue 1/2018

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Abstract

Background

Pesticides are an agricultural chemical suspected to be a significant contributor to a global diabetes pandemic. The purpose of this study was to confirm previous findings of the link between diabetes and some agricultural pesticides and to identify the particular pesticides that are most likely to pose a risk of diabetes in the community.

Methods

A population-based case-controlled study was conducted among residents in the Bang Rakam district of Phitsanulok Province in Thailand. Lifetime pesticide exposure and other relevant data were collected from 866 participating cases with diabetes mellitus and 1021 healthy controls.

Results

After adjusting for gender, age, BMI, cigarette smoking, alcohol consumption, family history of diabetes, and occupation, it was found that the prevalence of diabetes was positively associated with exposure to all types of pesticides, including insecticides, herbicides, fungicides, rodenticides, and molluscicides, with exposure to rodenticides being statistically significant (OR = 1.35; 95%CI 1.04–1.76). Among 35 individual brand-named pesticides investigated, we found statistically significant ORs with three insecticides, including one organochlorine [endosulfan (OR = 1.40; 95%CI 1.01–1.95)], one organophosphate [mevinphos (OR = 2.22; 95%CI 1.17–4.19)], and one carbamate [carbaryl/Sevin (OR = 1.50; 95%CI 1.02–2.19)]; and one fungicides [benlate (OR = 2.08; 95%CI 1.03–4.20)].

Conclusions

Our results suggest that the occurrence of diabetes among Thai farmer was associated with pesticide exposure. This finding is in line with previous epidemiological and animal studies. Further study using a larger sample size is needed to confirm the relationship and to identify the more toxic compounds.
Literature
1.
International Diabetes Federation. Idf Diabetes Atlas—7th edition. International Diabetes Federation. 2015.
2.
Thai NCD network. Situation of NCDs (2nd report):“Kick off to the Goals.” Nontaburi: The International Health Policy Program, Thailand (IHPP); 2016.
3.
Baliunas DO, Taylor BJ, Irving H, Roerecke M, Patra J, Mohapatra S, et al. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2009;32(11):2123–32.PubMedPubMedCentralCrossRef
4.
Rockette-Wagner B, Edelstein S, Venditti EM, Reddy D, Bray GA, Carrion-Petersen ML, et al. The impact of lifestyle intervention on sedentary time in individuals at high risk of diabetes. Diabetologia. 2015;58(6):1198–202.PubMedPubMedCentralCrossRef
5.
Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes. JAMA. 2007;298(22):2654.PubMedCrossRef
6.
Yu JH, Yun C-H, Ahn JH, Suh S, Cho HJ, Lee SK, et al. Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults. J Clin Endocrinol Metab. 2015;100(4):1494–502.PubMedCrossRef
7.
Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2010;33(2):414–20.PubMedCrossRef
8.
Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 2002;25(10):1862–8.PubMedCrossRef
9.
Kuo C-C, Moon K, Thayer KA, Navas-Acien A. Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence. Curr Diab Rep. 2013;13(6):831–49.PubMedPubMedCentralCrossRef
10.
Lee D-H, Lee I-K, Song K, Steffes M, Toscano W, Baker BA, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and examination survey 1999-2002. Diabetes Care. 2006;29(7):1638–44.PubMedCrossRef
11.
Vasiliu O, Cameron L, Gardiner J, DeGuire P, Karmaus W. Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus. Epidemiology. 2006;17(4):352–9.PubMedCrossRef
12.
Thayer KA, Heindel JJ, Bucher JR, Gallo MA. Role of environmental chemicals in diabetes and obesity: a national toxicology program workshop review. Environ Health Perspect. 2012;120(6):779–89.PubMedPubMedCentralCrossRef
13.
14.
Montgomery MP, Kamel F, Saldana TM, Alavanja MCR, Sandler DP. Incident diabetes and pesticide exposure among licensed pesticide applicators: agricultural health study, 1993-2003. Am J Epidemiol. 2008;167(10):1235–46.PubMedPubMedCentralCrossRef
15.
Starling AP, Umbach DM, Kamel F, Long S, Sandler DP, Hoppin JA. Pesticide use and incident diabetes among wives of farmers in the agricultural health study. Occup Environ Med. 2014;71(9):629–35.PubMedPubMedCentralCrossRef
16.
Saldana TM, Basso O, Hoppin JA, Baird DD, Knott C, Blair A, et al. Pesticide exposure and self-reported gestational diabetes mellitus in the agricultural health study. Diabetes Care. 2007;30(3):529–34.PubMedPubMedCentralCrossRef
17.
Benjamin N, Kushwah A, Sharma RK, Katiyar AK. Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats. Indian J Exp Biol. 2006;44(3):228–32.PubMed
18.
Cox S, Niskar AS, Venkat Narayan KM, Marcus M. Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic health and nutrition examination survey, 1982-1984. Environ Health Perspect. 2007;115(12):1747–52.PubMedPubMedCentralCrossRef
19.
Codru N, Schymura MJ, Negoita S, Rej R, Carpenter DO. Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult native Americans. Environ Health Perspect. 2007;115(10):1442–7.PubMedPubMedCentral
20.
Dirinck E, Jorens PG, Covaci A, Geens T, Roosens L, Neels H, et al. Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls. Obesity. 2011;19(4):709–14.PubMedCrossRef
21.
Sargis RM. The hijacking of cellular signaling and the diabetes epidemic: mechanisms of environmental disruption of insulin action and glucose homeostasis. Diabetes Metab. 2014;28:13–24.CrossRef
22.
Rahimi R, Abdollahi M. A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pestic Biochem Physiol. 2007;88(2):115–21.CrossRef
23.
Hectors TLM, Vanparys C, Van Der Ven K, Martens GA, Jorens PG, Van Gaal LF, et al. Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function. Diabetologia. 2011;54(6):1273–90.PubMedCrossRef
24.
Rezg R, Mornagui B, El-Fazaa S, Gharbi N. Organophosphorus pesticides as food chain contaminants and type 2 diabetes: a review. Trends Food Sci Technol. 2010;21(7):345–57.CrossRef
25.
Park WH, Kang YC, Piao Y, Pak DH, Pak YK. Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic. Arch Pharm Res. 2013;36:178–88.PubMedCrossRef
26.
27.
Ozmen O, Sahinduran S, Mor F. Pathological and immunohistochemical examinations of the pancreas in subacute endosulfan toxicity in rabbits. Pancreas. 2010;39(3):367–70.PubMedCrossRef
28.
van Koppen CJ, Kaiser B. Regulation of muscarinic acetylcholine receptor signaling. Pharmacol Ther. 2003;98(2):197–220.PubMedCrossRef
29.
Popovska M, Dubocovich M, Rajnarayanan R. The insecticides carbaryl and carbofuran show high affinity for hMT2 melatonin receptors (662.12). FASEB J. 2014;28(1 Supplement 662.12):926.5.
30.
Van Hall A, Popovska-Gorevski MJA, Rajnarayanan R, Dubocovich M. Federation proceedings. FASEB J. 2015;29(1 Supplement 776.4):926.5.
31.
Kang HK, Dalager NA, Needham LL, Patterson DG, Lees PSJ, Yates K, et al. Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. Am J Ind Med. 2006;49(11):875–84.PubMedCrossRef
32.
Beard J, Sladden T, Morgan G, Berry G, Brooks L, McMichael A. Health impacts of pesticide exposure in a cohort of outdoor workers. Environ Health Perspect. 2003;111(5):724–30.PubMedPubMedCentralCrossRef
33.
34.
35.
Grimes DA, Schulz KF. Bias and causal associations in observational research. Lancet. 2002;359(9302):248–52.PubMedCrossRef
Metadata
Title
Association between diabetes and pesticides: a case-control study among Thai farmers
Authors
Chudchawal Juntarawijit
Yuwayong Juntarawijit
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Environmental Health and Preventive Medicine / Issue 1/2018
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1186/s12199-018-0692-5

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