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Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 1/2017

Open Access 01-12-2017 | Research article

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice

Authors: Hiroki Yoshioka, Haruki Usuda, Hirohisa Fujii, Tsunemasa Nonogaki

Published in: Environmental Health and Preventive Medicine | Issue 1/2017

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Abstract

Background

The aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on acetaminophen (APAP)-induced hepatotoxicity.

Methods

Seven-week-old male ddY mice were orally administered SE or saline (0.2 mL) once a day for a week. Twenty-four hours after the last pretreatment, the mice were intraperitoneally injected with 550 mg/kg APAP or saline under fasting conditions. The mice from each group were euthanized and bled for plasma analysis 2, 6, 24, and 72 h after the injection.

Results

We found that pretreatment with SE significantly decreased hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase), oxidative stress (malondialdehyde and glutathione level), inflammatory cytokines, histological damage, c-jun N-terminal kinase activation, and receptor-interacting protein-1 activation. Further, SE pretreatment decreased Cyp2e1 expression and increased total antioxidant capacity in the liver.

Conclusion

Our findings demonstrate that prophylactic SE treatment protects mice from APAP-induced hepatotoxicity through modulation of Cyp2e1 expression and antioxidant capacity.
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Metadata
Title
Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice
Authors
Hiroki Yoshioka
Haruki Usuda
Hirohisa Fujii
Tsunemasa Nonogaki
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Environmental Health and Preventive Medicine / Issue 1/2017
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1186/s12199-017-0662-3

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