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Environmental Health and Preventive Medicine

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Open Access 01-12-2017 | Research article

Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function

Authors: Rishila Ghosh, Manushi Siddarth, Neeru Singh, Vipin Tyagi, Pawan Kumar Kare, Basu Dev Banerjee, Om Prakash Kalra, Ashok Kumar Tripathi

Published in: Environmental Health and Preventive Medicine | Issue 1/2017

Abstract

Background

Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study.

Methods

All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100). Blood OCP levels of all three study groups were analyzed by gas chromatography.

Results

Increased level of OCPs, namely α-HCH, aldrin, and β-endosulfan, were observed in CKDu patients as compared to healthy control and CKD patients of known etiology. The levels of these pesticides significantly correlated negatively with the estimated glomerular filtration rate (eGFR) and positively with urinary albumin of CKD patients. Logistic regression analysis revealed association of γ-HCH, p, p′-DDE, and β-endosulfan with CKDu on adjustment of age, sex, BMI, and total lipid content.

Conclusions

Increased blood level of certain organochlorine pesticides is associated with the development of chronic kidney disease of unknown etiology.

Lopez-Novoa JM, Rodriguez-Pena AB, Ortiz A, Martinez-Salgado C, Lopez Hernandez FJ. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. J Transl Med. 2011;1479:9–13.

Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF. What do we know about chronic kidney disease in India: first report of the Indian CKD registry? BMC Nephrol. 2012;13:1–10.CrossRef

Herrera CR, Orantes M, Almaguer M, Alfonso P, Hector D, Bayarre ML. Clinical characteristics of chronic kidney disease of non-traditional causes in Salvadoran farming communities. MEDICC Rev. 2014;16:39–48.PubMed

Silva LC, Ordonez P. Chronic kidney disease in Central American agricultural communities: challenges for epidemiology and public health. MEDICC Rev. 2014;16:66–71.PubMed

Ruiz-Suarez LE, Castro-Chan RA, Rivero-Perez NE. Levels of organochlorine pesticides in blood plasma from residents of malaria-endemic communities in Chiapas, Mexico. Int J Environ Res Public Health. 2014;11:44–60.CrossRef

Jayasinghe S. Chronic kidney disease of unknown etiology should be renamed chronic agrochemical nephropathy. MEDICC Rev. 2014;16:72–4.PubMed

Carreno J, Rivas A, Granada A. Exposure of young men to organochlorine pesticides in southern Spain. Environ Res. 2007;103:55–61.CrossRefPubMed

Medehouenou TC, Ayotte P, Carmichael PH, Kroger E, Verreault R. Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians. Environ Res. 2011;111:1313–20.CrossRefPubMed

Alvarado-Hernandez DL, Montero-Montoya R, Serrano-Garce L, Arellano-Aguilar O, Jasso-Pineda Y, Yanez-Estrada L. Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother–infant pairs of an agrarian community. Environ Mol Mutagen 2013; DOI 10.1002/em.21753.

10.

Banerjee BD, Mustafa MD, Sharma T, Tyagi V, Ahmed RS, Tripathi AK, Guleria K. Assessment of toxicogenomic risk factors in etiology of preterm delivery. Reprod Syst Sex Disord. 2014;3:1–10.

11.

Wahab A, Hod R, Noor H, Omar N. The effect of pesticide exposure on cardiovascular system: a systematic review. Int J Community Med Public Health. 2016;3:1–10.CrossRef

12.

Rigneall-Hydbom A, Rylander L, Hagmar L. Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol. 2007;26:447–52.CrossRef

13.

Levey S, Stevens A, Schmid H, Zhang Y, Castro F, Feldman I. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;9:604–12.CrossRef

14.

Wanigasuriya J. Aetiological factors of chronic kidney disease in North Central Province of Sri Lanka: a review of evidence to-date. J College Community Physicians Sri Lanka. 2012;17:15–20.CrossRef

15.

Bernert JT, Turner WE, Patterson DG, Needham LL. Calculation of serum “total lipid” concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples. Chemosphere. 2007;68:824–31.CrossRefPubMed

16.

Bush B, Snow J, Koblintz R. Polychlorobiphenyl (PCB) congeners, p, p′-DDE and hexachlorobenzene in maternal and fetal cord blood from mothers in Upstate New York. Arch Environ Contam Toxicol. 1984;13:517–27.CrossRefPubMed

17.

Siddharth M, Datta S, Mustafa MD, Ahmed R, Banerjee BD, Kalra OP, Tripathi AK. Increased level of organochlorine pesticides in chronic kidney disease patients of unknown etiology: role of GSTM1/GSTT1 polymorphism. Chemosphere. 2014;96:174–79.CrossRef

18.

Rutten GA, Schoots AC, Vanholder R, Desmet R, Ringoir SM, Cramers CA. Hexachlorobenzene and 1,1-di(4-chlorophenyl)-2,2-dichloroethene in serum of uremic patients and healthy persons: determination by capillary gas chromatography and electron capture detection. Nephron. 1988;48:217–21.CrossRefPubMed

19.

Siddharth M, Datta S, Bansal S, Mustafa M, Banerjee BD, Kalra OP. Study on organochlorine pesticide levels in chronic kidney disease patients: association with estimated glomerular filtration rate and oxidative stress. Biochem Mol Toxicol. 2012;26:241–47.CrossRef

20.

Choudhary N, Sharma M, Verma P, Joshi SC. Hepato and nephrotoxicity in rat exposed to endosulfan. J Environ Biol. 2003;24:305–8.PubMed

21.

Uboh FE, Asuquo EN, Eteng MU, Akpanyung EO. Endosulphan-induces renal toxicity independent of the route of exposure in rats. Am J Biochem Mol Biol. 2011;1:359–67.CrossRef

22.

Banerjee BD, Seth V, Ahmed RS. Pesticide-induced oxidative stress: perspectives and trends. Rev Environ Health. 2001;16:1–40.CrossRefPubMed

23.

Ahmed T, Tripathi AK, Ahmed RS, Das S, Suke SG, Pathak R. Endosulfan-induced apoptosis and glutathione depletion in human peripheral blood mononuclear cells: attenuation by N-acetylcysteine. J Biochem Mol Toxicol. 2008;22:299–304.CrossRefPubMed

24.

Small DM, Coombes JS, Bennett N, Johnson D, Gobe G. Oxidative stress, anti-oxidant therapies and chronic kidney disease. Nephrology. 2012;17:311–21.CrossRefPubMed

25.

Lopez-Marin L, Chavez Y, Garcia XA, Flores WM, Garcia YM, Herrera R. Histopathology of chronic kidney disease of unknown etiology in Salvadoran agricultural communities. MEDICC. 2014;16:49–54.

26.

Kataria A, Trasande L, Trachtman H. The effects of environmental chemicals on renal function. Nat Rev Nephrol. 2015;11:610–25.CrossRefPubMedPubMedCentral

27.

Ledirac N, Antherieu S, Dub AD. Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. Toxicol Sci. 2005;86:444–52.CrossRefPubMed

Title: Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function
Authors: Rishila Ghosh
Manushi Siddarth
Neeru Singh
Vipin Tyagi
Pawan Kumar Kare
Basu Dev Banerjee
Om Prakash Kalra
Ashok Kumar Tripathi
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Environmental Health and Preventive Medicine / Issue 1/2017
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-017-0660-5

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Organochlorine pesticide level in patients with chronic kidney disease of unknown etiology and its association with renal function

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

Methods

Results

Conclusions

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