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Open Access 01-12-2017 | Short communication

Spontaneous twin pregnancy with live births after cryopreservation and re-implantation of ovarian tissue

Authors: Milan Milenkovic, Mats Brännström, Cesar Diaz-Garcia, Kersti Lundin, Ulrika Selleskog, Brita Söderlund, Ali Khatibi, Berit Gull, Hans Bokström, Claudia Mateoiu, Levent M. Akyürek, Ann Thurin-Kjellberg

Published in: Gynecological Surgery | Issue 1/2017

Excerpt

Ovarian tissue cryopreservation (OTC) before gonadotoxic treatment and subsequent avascular auto-transplantation is a method of fertility preservation in cancer patients, with first birth reported in 2004 [1]. This method has resulted in more than 85 livebirths worldwide [2‐4], with delivery rate of 25–32% per transplanted woman [2, 3]. …

Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J et al (2004) Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 364:1405–1410CrossRefPubMed

Meirow D, Ra'anani H, Shapira M, Brenghausen M, Derech Chaim S, Aviel-Ronen S et al (2016) Transplantations of frozen-thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria. Fertil Steril 106:467–474CrossRefPubMed

Van der Ven H, Liebenthron J, Beckmann M, Toth B, Korell M, Krussel J et al (2016) Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates. Hum Reprod 31:2031–2041CrossRefPubMed

Jensen AK, Macklon KT, Fedder J, Ernst E, Humaidan P, Andersen KY (2017) 86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children. J Assist Reprod and Genet 34:325–336CrossRef

Gosden RG, Baird DT, Wade JC, Webb R (1994) Restoration of fertility to oophorectomized sheep by ovarian autografts stored at −196 degrees C. Hum Reprod 9:597–603CrossRefPubMed

Brannström M, Johannesson L, Bokström H, Kvarnström N, Mölne J, Dahm-Kahler P et al (2014) Livebirth after uterus transplantation. Lancet 385(9968):607–616CrossRefPubMed

Diaz-Garcia C, Milenkovic M, Groth K, Dahm-Kahler P, Olausson M, Brannstrom M (2011) Ovarian cortex transplantation in the baboon: comparison of four different intra-abdominal transplantation sites. Hum Reprod 26:3303–3311CrossRefPubMed

Title: Spontaneous twin pregnancy with live births after cryopreservation and re-implantation of ovarian tissue
Authors: Milan Milenkovic
Mats Brännström
Cesar Diaz-Garcia
Kersti Lundin
Ulrika Selleskog
Brita Söderlund
Ali Khatibi
Berit Gull
Hans Bokström
Claudia Mateoiu
Levent M. Akyürek
Ann Thurin-Kjellberg
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Gynecological Surgery / Issue 1/2017
Print ISSN: 1613-2076
Electronic ISSN: 1613-2084
DOI: https://doi.org/10.1186/s10397-017-1012-6

At a glance: The STEP trials

Springer Medicine

Spontaneous twin pregnancy with live births after cryopreservation and re-implantation of ovarian tissue

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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