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Open Access 01-12-2018 | Review article

Discovery of PACAP and its receptors in the brain

Authors: Takahiro Hirabayashi, Tomoya Nakamachi, Seiji Shioda

Published in: The Journal of Headache and Pain | Issue 1/2018

Abstract

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R). These receptors have high homology to each other, and their high homology is utilized for these discoveries. This review provides mainly an overview of the history of the discovery of PACAP and its three receptors.

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Title: Discovery of PACAP and its receptors in the brain
Authors: Takahiro Hirabayashi
Tomoya Nakamachi
Seiji Shioda
Publication date: 01-12-2018
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2018
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-018-0855-1

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