Skip to main content
Top
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2016 | Research article

Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk

Authors: Ali Sazci, Gensay Sazci, Bilgen Sazci, Emel Ergul, Halil Atilla Idrisoglu

Published in: The Journal of Headache and Pain | Issue 1/2015

Login to get access

Abstract

Background

Migraine is a common neurovascular disorder affecting 10 to 20 % of the world population usually subdivided into migraine with auro (MA) and migraine without auro (MO). Homocysteine is involved in the pathophysiology of a number of neurological disorders. Elevated levels of homocysteine in the plasma is produced by the MTHFR gene rs 1801133 and rs 1801131 variants as well as the NNMT gene rs 694539 variant.

Methods

With the polymerase chain reaction-restriction fragment length polymorphism method developed recently in our laboratory, we were able to show an association between the NNMT gene rs694539 variant and migraine for the first time.

Results

Here we report the association of the Nicotinamide-N-methyltransferase gene (NNMT) rs694539 variant with migraine in a case–control study of 433 patients with migraine and 229 healthy controls (χ2 = 6.076, P = 0.048). After stratification, we were able only to show an association between the NNMT gene rs694539 variant and female patients with migraine on the genotype and allelic levels. However there was no association in male patients with migraine (χ2 = 1.054, P = 0.590).

Conclusions

Consequently our results clearly indicate that the NNMT gene rs694539 variant is a genetic risk factor for migraine.
Literature
1.
go back to reference Kara I, Sazci A, Ergul E, Kaya G, Kilic G (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 111(1–2):84–90PubMedCrossRef Kara I, Sazci A, Ergul E, Kaya G, Kilic G (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 111(1–2):84–90PubMedCrossRef
2.
go back to reference Sazci A, Ergul E, Bayulkem K (2004) Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. Mov Disord 19(12):1472–1476PubMedCrossRef Sazci A, Ergul E, Bayulkem K (2004) Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. Mov Disord 19(12):1472–1476PubMedCrossRef
3.
go back to reference Sazci A, Ergul E, Tuncer N, Akpinar G, Kara I (2006) Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull 71(1-3):45–50PubMedCrossRef Sazci A, Ergul E, Tuncer N, Akpinar G, Kara I (2006) Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C. Brain Res Bull 71(1-3):45–50PubMedCrossRef
5.
go back to reference Sazci A, Ergül E, Güzelhan Y, Kaya G, Kara I (2003) Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Mol Brain Res 117(1):104–107PubMedCrossRef Sazci A, Ergül E, Güzelhan Y, Kaya G, Kara I (2003) Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Mol Brain Res 117(1):104–107PubMedCrossRef
6.
go back to reference Sazci A, Ergul E, Kucukali I, Kara I, Kaya G (2005) Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women. Prog Neuropsychopharmacol Biol Psychiatry 29(7):1113–1123PubMedCrossRef Sazci A, Ergul E, Kucukali I, Kara I, Kaya G (2005) Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women. Prog Neuropsychopharmacol Biol Psychiatry 29(7):1113–1123PubMedCrossRef
7.
go back to reference Ozbek Z, Kucukali CI, Ozkok E, Orhan N, Aydin M, Kilic G, Sazci A, Kara I (2008) Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.Prog. Neuropsychopharmacol Biol Psychiatry 32(5):1331–1337CrossRef Ozbek Z, Kucukali CI, Ozkok E, Orhan N, Aydin M, Kilic G, Sazci A, Kara I (2008) Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.Prog. Neuropsychopharmacol Biol Psychiatry 32(5):1331–1337CrossRef
8.
go back to reference Sazci A, Ozel MD, Ergul E, Onder ME (2013) Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder. Gene 532(2):272–275PubMedCrossRef Sazci A, Ozel MD, Ergul E, Onder ME (2013) Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder. Gene 532(2):272–275PubMedCrossRef
9.
go back to reference Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10(1):111–113PubMedCrossRef Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10(1):111–113PubMedCrossRef
10.
go back to reference Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64(3):169–172PubMedCrossRef Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64(3):169–172PubMedCrossRef
11.
go back to reference Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K (2000) The homozygous C677T mutation in the methylenetetrahydro-folate reductase gene is a genetic risk factor for migraine. Neuro-psychiatric Genet 96:762–764 Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K (2000) The homozygous C677T mutation in the methylenetetrahydro-folate reductase gene is a genetic risk factor for migraine. Neuro-psychiatric Genet 96:762–764
12.
go back to reference Lea RA, Ovcaric M, Sundholm J, MacMillan J, Griffiths LR (2004) The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med 2(1):3PubMedPubMedCentralCrossRef Lea RA, Ovcaric M, Sundholm J, MacMillan J, Griffiths LR (2004) The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med 2(1):3PubMedPubMedCentralCrossRef
13.
go back to reference Lea RA, Ovcaric M, Sundholm J, Solyom L, Macmillan J, Griffiths LR (2005) Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility.Mol. Brain Res 136(1-2):112–117CrossRef Lea RA, Ovcaric M, Sundholm J, Solyom L, Macmillan J, Griffiths LR (2005) Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility.Mol. Brain Res 136(1-2):112–117CrossRef
14.
go back to reference Oterino A, Valle N, Pascual J, Bravo Y, Muñoz P, Castillo J, Ruiz-Alegría C, Sánchez-Velasco P, Leyva-Cobián F, Cid C (2005) Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. Mol Brain Res 139(1):163–168PubMedCrossRef Oterino A, Valle N, Pascual J, Bravo Y, Muñoz P, Castillo J, Ruiz-Alegría C, Sánchez-Velasco P, Leyva-Cobián F, Cid C (2005) Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. Mol Brain Res 139(1):163–168PubMedCrossRef
15.
go back to reference Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, Frants RR, van den Maagdenberg AM, van Buchem M, Ferrari MD, Launer LJ (2006) Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 59(2):372–375PubMedCrossRef Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, Frants RR, van den Maagdenberg AM, van Buchem M, Ferrari MD, Launer LJ (2006) Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 59(2):372–375PubMedCrossRef
16.
go back to reference Pezzini A, Grassi M, Del Zotto E, Giossi A, Monaste ro R, Dalla Volta G, Archetti S, Zavarise P, Camarda C, Gasparotti R (2007) Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect. Stroke 38(12):3145–3151PubMedCrossRef Pezzini A, Grassi M, Del Zotto E, Giossi A, Monaste ro R, Dalla Volta G, Archetti S, Zavarise P, Camarda C, Gasparotti R (2007) Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect. Stroke 38(12):3145–3151PubMedCrossRef
17.
go back to reference Schurks M, Zee RY, Buring JE, Kurth T (2008) Interrelationships among the MTHFR 677C T polymorphism, migraine, and cardiovascular disease. Neurology 71(7):505–513PubMedPubMedCentralCrossRef Schurks M, Zee RY, Buring JE, Kurth T (2008) Interrelationships among the MTHFR 677C T polymorphism, migraine, and cardiovascular disease. Neurology 71(7):505–513PubMedPubMedCentralCrossRef
18.
go back to reference Tietjen G, Herial N, Utley C, White L, Yerga-Woolwine S, Joe B (2009) Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine. Cephalalgia 29(9):960–968PubMedCrossRef Tietjen G, Herial N, Utley C, White L, Yerga-Woolwine S, Joe B (2009) Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine. Cephalalgia 29(9):960–968PubMedCrossRef
19.
go back to reference Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA (2013) Effects of MTHFR gene 1325 polymorphism on the clinical and electrophysiological characteristics of migraine. BMC Neurol 13(1):103PubMedPubMedCentralCrossRef Azimova JE, Sergeev AV, Korobeynikova LA, Kondratieva NS, Kokaeva ZG, Shaikhaev GO, Skorobogatykh KV, Fokina NM, Tabeeva GR, Klimov EA (2013) Effects of MTHFR gene 1325 polymorphism on the clinical and electrophysiological characteristics of migraine. BMC Neurol 13(1):103PubMedPubMedCentralCrossRef
20.
go back to reference An X-K, Lu C-X, Ma Q-L, Zhang X-R, Burgunder J-M, Lin Q, Qu H-L (2013) Association of MTHFR C677T polymorphism with susceptibility to migraine in the Chinese population. Neurosci Lett 549:78–81PubMedCrossRef An X-K, Lu C-X, Ma Q-L, Zhang X-R, Burgunder J-M, Lin Q, Qu H-L (2013) Association of MTHFR C677T polymorphism with susceptibility to migraine in the Chinese population. Neurosci Lett 549:78–81PubMedCrossRef
21.
go back to reference Liu A, Menon S, Colson NJ, Quinlan S, Cox H, Peterson M, Tiang T, Haupt LM, Lea RA, Griffiths LR (2010) Analysis of the MTHFR 2018 C677T variant with migraine phenotypes. BMC Res Notes 3(1):213PubMedPubMedCentralCrossRef Liu A, Menon S, Colson NJ, Quinlan S, Cox H, Peterson M, Tiang T, Haupt LM, Lea RA, Griffiths LR (2010) Analysis of the MTHFR 2018 C677T variant with migraine phenotypes. BMC Res Notes 3(1):213PubMedPubMedCentralCrossRef
22.
go back to reference Liu R, Geng P, Ma M, Yu S, Yang M, He M, Dong Z, Zhang W (2014) MTHFR C677T polymorphism and migraine risk: a meta-analysis. J Neurol Sci 336(1-2):68–73PubMedCrossRef Liu R, Geng P, Ma M, Yu S, Yang M, He M, Dong Z, Zhang W (2014) MTHFR C677T polymorphism and migraine risk: a meta-analysis. J Neurol Sci 336(1-2):68–73PubMedCrossRef
23.
go back to reference Sano A, Endo N, Takitani S (1992) Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides. Chem Pharm Bull (Tokyo) 40:153–156CrossRef Sano A, Endo N, Takitani S (1992) Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides. Chem Pharm Bull (Tokyo) 40:153–156CrossRef
24.
go back to reference Aksoy S, Szumlanski CL, Weinshilboum RM (1994) Human liver nicotinamideN-methyltransferase. cDNA cloning, expression, and biochemical characterization. J Biol Chem 269:14835–14840PubMed Aksoy S, Szumlanski CL, Weinshilboum RM (1994) Human liver nicotinamideN-methyltransferase. cDNA cloning, expression, and biochemical characterization. J Biol Chem 269:14835–14840PubMed
25.
go back to reference Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordoñez-Llanos J, Martín-Campos JM, Lathrop M, Stone W, Blangero J, Fontcuberta J (2005) A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet 76(6):925–933PubMedPubMedCentralCrossRef Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordoñez-Llanos J, Martín-Campos JM, Lathrop M, Stone W, Blangero J, Fontcuberta J (2005) A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet 76(6):925–933PubMedPubMedCentralCrossRef
26.
go back to reference Headache Classification Committee of the International Headache Society (2013) The international classification of headache disorders, 3rd edition. Cephalalgia 33:629–808, beta versionCrossRef Headache Classification Committee of the International Headache Society (2013) The international classification of headache disorders, 3rd edition. Cephalalgia 33:629–808, beta versionCrossRef
27.
28.
go back to reference Sazci A, Ozel MD, Ergul E, Aygun C (2013) Association of nicotinamide-N-methyltransferase gene rs694539 variant with patients with nonalcoholic steatohepatitis. Genet Test Mol Biomarkers 17(11):849–853PubMedCrossRef Sazci A, Ozel MD, Ergul E, Aygun C (2013) Association of nicotinamide-N-methyltransferase gene rs694539 variant with patients with nonalcoholic steatohepatitis. Genet Test Mol Biomarkers 17(11):849–853PubMedCrossRef
29.
go back to reference Geyik S, Ergun S, Kuzudişli S, Şensoy F, Temiz E, Altunışık E, Korkmaz M, Dağlı H, Kul S, Akçalı A, Neyal AM (2016) Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines. J Headache Pain 17:36–43PubMedPubMedCentralCrossRef Geyik S, Ergun S, Kuzudişli S, Şensoy F, Temiz E, Altunışık E, Korkmaz M, Dağlı H, Kul S, Akçalı A, Neyal AM (2016) Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines. J Headache Pain 17:36–43PubMedPubMedCentralCrossRef
30.
go back to reference Fang J, An X, Chen S, Yu Z, Ma Q, Qu H (2015) Case-control study of GRIA1 and GRIA3 gene variants in migraine. J Headache Pain 17:2–7PubMedCrossRef Fang J, An X, Chen S, Yu Z, Ma Q, Qu H (2015) Case-control study of GRIA1 and GRIA3 gene variants in migraine. J Headache Pain 17:2–7PubMedCrossRef
31.
go back to reference Wan D, Hou L, Zhang X, Han X, Chen M, Tang W, Liu R, Dong Z, Yu S (2015) DNA methylation of RAMP1 gene in migraine: an exploratory analysis. J Headache Pain 16:90–95PubMedPubMedCentralCrossRef Wan D, Hou L, Zhang X, Han X, Chen M, Tang W, Liu R, Dong Z, Yu S (2015) DNA methylation of RAMP1 gene in migraine: an exploratory analysis. J Headache Pain 16:90–95PubMedPubMedCentralCrossRef
32.
go back to reference Lin QF, Fu XG, Yao LT, Yang J, Cao LY, Xin YT, Hou JX, Ye LF, Huang GB (2015) Association of genetic loci for migraine susceptibility in the she people of China. J Headache Pain 16:553–559PubMedCrossRef Lin QF, Fu XG, Yao LT, Yang J, Cao LY, Xin YT, Hou JX, Ye LF, Huang GB (2015) Association of genetic loci for migraine susceptibility in the she people of China. J Headache Pain 16:553–559PubMedCrossRef
33.
go back to reference Rodriguez-Acevedo AJ, Smith RA, Roy B, Sutherland H, Lea RA, Frith A, MacGregor EA, Griffiths LR (2014) Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. J Headache Pain 15:62. doi:10.1186/1129-2377-15-62 PubMedPubMedCentralCrossRef Rodriguez-Acevedo AJ, Smith RA, Roy B, Sutherland H, Lea RA, Frith A, MacGregor EA, Griffiths LR (2014) Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. J Headache Pain 15:62. doi:10.​1186/​1129-2377-15-62 PubMedPubMedCentralCrossRef
34.
go back to reference Nyholt DR, van den Maagdenberg AM (2016) Genome-wide association studies in migraine: current state and route to follow. Curr Opin Neurol 29(3):302–308PubMedCrossRef Nyholt DR, van den Maagdenberg AM (2016) Genome-wide association studies in migraine: current state and route to follow. Curr Opin Neurol 29(3):302–308PubMedCrossRef
35.
go back to reference Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Müller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hämäläinen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Göbel H, Steinberg S, Wolf C, Björnsson A, Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG, Hagen K, Stovner L, Wichmann HE, Meitinger T, Alexander M, Moebus S, Schreiber S, Aulchenko YS, Breteler MM, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsäläinen S, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Färkkilä M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J, Daly M, Wessman M, van den Maagdenberg AM, Dichgans M, Kubisch C, Dermitzakis ET, Frants RR, Palotie A, International Headache Genetics Consortium (2010) Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 42(10):869–873PubMedPubMedCentralCrossRef Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Müller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hämäläinen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Göbel H, Steinberg S, Wolf C, Björnsson A, Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG, Hagen K, Stovner L, Wichmann HE, Meitinger T, Alexander M, Moebus S, Schreiber S, Aulchenko YS, Breteler MM, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsäläinen S, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Färkkilä M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J, Daly M, Wessman M, van den Maagdenberg AM, Dichgans M, Kubisch C, Dermitzakis ET, Frants RR, Palotie A, International Headache Genetics Consortium (2010) Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 42(10):869–873PubMedPubMedCentralCrossRef
36.
go back to reference Chasman DI, Schurks M, Anttila V, de Vries B, Schminke U, Launer LJ, Terwindt GM, van den Maagdenberg AM, Fendrich K, Volzke H, Ernst F, Griffiths LR, Buring JE, Kallela M, Freilinger T, Kubisch C, Ridker PM, Palotie A, Ferrari MD, Hoffmann W, Zee RY, Kurth T (2011) Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 43:695–698PubMedPubMedCentralCrossRef Chasman DI, Schurks M, Anttila V, de Vries B, Schminke U, Launer LJ, Terwindt GM, van den Maagdenberg AM, Fendrich K, Volzke H, Ernst F, Griffiths LR, Buring JE, Kallela M, Freilinger T, Kubisch C, Ridker PM, Palotie A, Ferrari MD, Hoffmann W, Zee RY, Kurth T (2011) Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 43:695–698PubMedPubMedCentralCrossRef
37.
go back to reference Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, PozoRosich P, Winsvold B, Nyholt DR, van Oosterhout WP, Artto V, Todt U, Hamalainen E, Fernandez-Morales J, Louter MA, Kaunisto MA, Schoenen J, Raitakari O, Lehtimaki T, Vila-Pueyo M, Gobel H, Wichmann E, Sintas C, Uitterlinden AG, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn CM, Kaprio J, Cormand B, Wessman M, Frants RR, Meitinger T, Müller-Myhsok B, Zwart JA, Farkkila M, Macaya M, Ferrari MD, Kubisch C, Palotie A, Dichgans M, van den Maagdenberg AM, International Headache Genetics Consortium (2012) Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet 44:777–782PubMedPubMedCentralCrossRef Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, PozoRosich P, Winsvold B, Nyholt DR, van Oosterhout WP, Artto V, Todt U, Hamalainen E, Fernandez-Morales J, Louter MA, Kaunisto MA, Schoenen J, Raitakari O, Lehtimaki T, Vila-Pueyo M, Gobel H, Wichmann E, Sintas C, Uitterlinden AG, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn CM, Kaprio J, Cormand B, Wessman M, Frants RR, Meitinger T, Müller-Myhsok B, Zwart JA, Farkkila M, Macaya M, Ferrari MD, Kubisch C, Palotie A, Dichgans M, van den Maagdenberg AM, International Headache Genetics Consortium (2012) Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet 44:777–782PubMedPubMedCentralCrossRef
38.
go back to reference Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68:1478–1484PubMedCrossRef Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68:1478–1484PubMedCrossRef
39.
go back to reference Rampalli S, Li L, Mak E, Ge K, Brand M, Tapscott SJ, Dilworth FJ (2007) p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nat Struct Mol Biol 14:1150–1156PubMedPubMedCentralCrossRef Rampalli S, Li L, Mak E, Ge K, Brand M, Tapscott SJ, Dilworth FJ (2007) p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Nat Struct Mol Biol 14:1150–1156PubMedPubMedCentralCrossRef
40.
go back to reference Speksnijder N, Christensen KV, Didriksen M, De Kloet ER, Datson NA (2012) Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-Jun in a neuronal context. J Mol Neurosci 48:209–218PubMedPubMedCentralCrossRef Speksnijder N, Christensen KV, Didriksen M, De Kloet ER, Datson NA (2012) Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-Jun in a neuronal context. J Mol Neurosci 48:209–218PubMedPubMedCentralCrossRef
41.
go back to reference Endo K, Karim MR, Taniguchi H, Krejci A, Kinameri E, Siebert M, Ito K, Bray SJ, Moore AW (2012) Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci 15:224–233CrossRef Endo K, Karim MR, Taniguchi H, Krejci A, Kinameri E, Siebert M, Ito K, Bray SJ, Moore AW (2012) Chromatin modification of Notch targets in olfactory receptor neuron diversification. Nat Neurosci 15:224–233CrossRef
43.
go back to reference Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A, North American Brain Expression Consortium, UK Brain Expression Consortium, International Headache Genetics Consortium (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 45(8):912–917PubMedPubMedCentralCrossRef Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A, North American Brain Expression Consortium, UK Brain Expression Consortium, International Headache Genetics Consortium (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 45(8):912–917PubMedPubMedCentralCrossRef
44.
go back to reference Osher Y, Sela BA, Levine J, Belmaker RH (2004) Elevated homocysteine levels in euthymic bipolar disorder patients showing functional deterioration. Bipolar Disord 6(1):82–86PubMedCrossRef Osher Y, Sela BA, Levine J, Belmaker RH (2004) Elevated homocysteine levels in euthymic bipolar disorder patients showing functional deterioration. Bipolar Disord 6(1):82–86PubMedCrossRef
45.
go back to reference Dittmann S, Hennig-Fast K, Gerber S, Seemüller F, Riedel M, Emanuel Severus W, Langosch J, Engel RR, Möller HJ, Grunze HC (2008) Cognitive functioning in euthymic bipolar I and bipolar II patients. Bipolar Disord 10(8):877–887PubMedCrossRef Dittmann S, Hennig-Fast K, Gerber S, Seemüller F, Riedel M, Emanuel Severus W, Langosch J, Engel RR, Möller HJ, Grunze HC (2008) Cognitive functioning in euthymic bipolar I and bipolar II patients. Bipolar Disord 10(8):877–887PubMedCrossRef
Metadata
Title
Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk
Authors
Ali Sazci
Gensay Sazci
Bilgen Sazci
Emel Ergul
Halil Atilla Idrisoglu
Publication date
01-12-2016
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-016-0688-8

Other articles of this Issue 1/2015

The Journal of Headache and Pain 1/2015 Go to the issue