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The Journal of Headache and Pain

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Open Access 01-12-2016 | Research article

Oxidative stress and DNA damage in patients with migraine

Authors: Sırma Geyik, Erman Altunısık, Ayse Münife Neyal, Seyithan Taysi

Published in: The Journal of Headache and Pain | Issue 1/2015

Abstract

Background

Oxidative stress is implicated in the pathogenesis of migraine, but no published studies have examined both oxidative stress levels and oxidative DNA damage on the same patient group.

Methods

In this study, total oxidant status (TOS); total antioxidant status (TAS); oxidative stress index (OSI); and 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is an indicator of oxidative DNA damage, were measured in the plasma samples of 50 prophylactic unmediated migraineurs (11 with aura and 39 without aura) and 30 matched healthy volunteers.

Results

No significant differences in TAS, TOS, and OSI values were observed between patients and controls. However, plasma 8-OHdG levels were found to be significantly higher in migraine patients than in the control group (p = 0.001); this increase in plasma 8-OHdG levels was more prominent in cases with migraine without aura than with aura (p = 0.001). Our results suggested an evidence of oxidative stress-related DNA damage in migraine.

Conclusion

DNA damage reflected by plasma 8-OHdG did not studied in migraine before. Therefore, further research on oxidative stress-related DNA damage and the extent of its clinical manifestations in migraine may provide additional data to our current knowledge.

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Title: Oxidative stress and DNA damage in patients with migraine
Authors: Sırma Geyik
Erman Altunısık
Ayse Münife Neyal
Seyithan Taysi
Publication date: 01-12-2016
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-016-0606-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oxidative stress and DNA damage in patients with migraine

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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