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Critical Care
Published in: Critical Care 5/2010

01-10-2010 | Letter

Direct antimicrobial activity of antithrombin?

Authors: Christian J Wiedermann, Angela Djanani

Published in: Critical Care | Issue 5/2010

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Excerpt

In a study by Hofstra and colleagues [1] in a recent issue of Critical Care, nebulization of drotrecogin-alfa (activated), antithrombin, heparin, or danaparoid attenuated pulmonary coagulopathy during Streptococcus pneumoniae pneumonia in rats; only antithrombin additionally exerted lung-protective effects and reduced bacterial outgrowth. Adding antithrombin to culture medium had no effect on the outgrowth of S. pneumoniae in vitro; thus, less neutralizing of endogenous antimicrobicidals by reduced bronchoalveolar fluid levels of inflammatory proteins could have permitted better endogenous microbicidal effects in the antithrombin group [1]. …
Literature
1.
Hofstra JJ, Cornet AD, de Rooy BF, Vlaar AP, van der Poll T, Levi M, Zaat SA, Schultz MJ: Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats. Crit Care 2009, 13: R145. 10.1186/cc8040PubMedCentralCrossRefPubMed
2.
Djanani A, Mosheimer B, Kaneider NC, Ross CR, Ricevuti G, Patsch JR, Wiedermann CJ: Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin. J Inflamm (Lond) 2006, 3: 14. 10.1186/1476-9255-3-14CrossRef
3.
Andersson E, Rydengård V, Sonesson A, Mörgelin M, Björck L, Schmidtchen A: Antimicrobial activities of heparin-binding peptides. Eur J Biochem 2004, 271: 1219-1226. 10.1111/j.1432-1033.2004.04035.xCrossRefPubMed
4.
Cardin AD, Weintraub HJ: Molecular modeling of proteinglycosaminoglycan interactions. Arteriosclerosis 1989, 9: 21-32.CrossRefPubMed
5.
Smith JW, Knauer DJ: A heparin binding site in antithrombin III. Identification, purification, and amino acid sequence. J Biol Chem 1987, 262: 11964-11972.PubMed
Metadata
Title
Direct antimicrobial activity of antithrombin?
Authors
Christian J Wiedermann
Angela Djanani
Publication date
01-10-2010
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9243

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