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Critical Care
Published in: Critical Care 4/2010

01-08-2010 | Commentary

The role of inflammation in ICU-acquired weakness

Author: Chris Winkelman

Published in: Critical Care | Issue 4/2010

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Abstract

A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.
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Weber-Carstens S, Koch S, Spuler S, Spies CD, Bubser F, Wernecke KD, Deja M: Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients. Crit Care Med 2009, 37: 2632-2637. 10.1097/CCM.0b013e3181a92f28CrossRefPubMed
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Metadata
Title
The role of inflammation in ICU-acquired weakness
Author
Chris Winkelman
Publication date
01-08-2010
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9187

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