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Critical Care
Published in: Critical Care 3/2009

Open Access 01-06-2009 | Research

Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study

Authors: Jacco J de Haan, Tim Lubbers, Joep P Derikx, Borna Relja, Dirk Henrich, Jan-Willem Greve, Ingo Marzi, Wim A Buurman

Published in: Critical Care | Issue 3/2009

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Abstract

Introduction

Loss of intestinal integrity has been implicated as an important contributor to the development of excessive inflammation following severe trauma. Thus far, clinical data concerning the occurrence and significance of intestinal damage after trauma remain scarce. This study investigates whether early intestinal epithelial cell damage occurs in trauma patients and, if present, whether such cell injury is related to shock, injury severity and the subsequent inflammatory response.

Methods

Prospective observational cohort study in 96 adult trauma patients. Upon arrival at the emergency room (ER) plasma levels of intestinal fatty acid binding protein (i-FABP), a specific marker for damage of differentiated enterocytes, were measured. Factors that potentially influence the development of intestinal cell damage after trauma were determined, including the presence of shock and the extent of abdominal trauma and general injury severity. Furthermore, early plasma levels of i-FABP were related to inflammatory markers interleukin-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP).

Results

Upon arrival at the ER, plasma i-FABP levels were increased compared with healthy volunteers, especially in the presence of shock (P < 0.01). The elevation of i-FABP was related to the extent of abdominal trauma as well as general injury severity (P < 0.05). Circulatory i-FABP concentrations at ER correlated positively with IL-6 and PCT levels at the first day (r2 = 0.19; P < 0.01 and r2 = 0.36; P < 0.001 respectively) and CRP concentrations at the second day after trauma (r2 = 0.25; P < 0.01).

Conclusions

This study reveals early presence of intestinal epithelial cell damage in trauma patients. The extent of intestinal damage is associated with the presence of shock and injury severity. Early intestinal damage precedes and is related to the subsequent developing inflammatory response.
Appendix
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Metadata
Title
Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study
Authors
Jacco J de Haan
Tim Lubbers
Joep P Derikx
Borna Relja
Dirk Henrich
Jan-Willem Greve
Ingo Marzi
Wim A Buurman
Publication date
01-06-2009
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2009
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7910

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