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Published in: Critical Care 4/2007

01-08-2007 | Commentary

Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?

Author: Daren K Heyland

Published in: Critical Care | Issue 4/2007

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Abstract

A recent study by Forceville and colleagues evaluated the effect of high-dose selenium administration as a treatment for septic shock. The study was negative and conflicts with existing clinical data regarding selenium administration in critically ill patients. Perhaps the key to understanding the differences between these discrepant observations lies in considering the dose and timing of selenium administration.
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Literature
1.
go back to reference Forceville X, Laviolle B, Annane D, Vitoux D, Bleichner G, Korach J-M, Cantais E, Georges H, Soubirou J-L, Combes A, Bellissant EB: Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care 2007, 11: R73. 10.1186/cc5960PubMedCentralCrossRefPubMed Forceville X, Laviolle B, Annane D, Vitoux D, Bleichner G, Korach J-M, Cantais E, Georges H, Soubirou J-L, Combes A, Bellissant EB: Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care 2007, 11: R73. 10.1186/cc5960PubMedCentralCrossRefPubMed
2.
go back to reference Heyland DK, Dhaliwal R, Suchner U, Berger M: Antioxidant nutrients: a systematic review of vitamins and trace elements in the critically ill patient. Int Care Med 2005, 31: 327-337. 10.1007/s00134-004-2522-zCrossRef Heyland DK, Dhaliwal R, Suchner U, Berger M: Antioxidant nutrients: a systematic review of vitamins and trace elements in the critically ill patient. Int Care Med 2005, 31: 327-337. 10.1007/s00134-004-2522-zCrossRef
3.
go back to reference Berger MM, Baines M, Chiolero R, Wardle CA, Cayeux C, Shenkin A: Influence of early trace element and vitamin E supplements on antioxidant status after major trauma: a controlled trial. Nutr Res 2001, 21: 41-54. 10.1016/S0271-5317(00)00296-7CrossRef Berger MM, Baines M, Chiolero R, Wardle CA, Cayeux C, Shenkin A: Influence of early trace element and vitamin E supplements on antioxidant status after major trauma: a controlled trial. Nutr Res 2001, 21: 41-54. 10.1016/S0271-5317(00)00296-7CrossRef
5.
go back to reference Spallholz JE: On the nature of selenium toxicity and carcinostatic activity. Free Radic Biol Med 1994, 17: 45-64. 10.1016/0891-5849(94)90007-8CrossRefPubMed Spallholz JE: On the nature of selenium toxicity and carcinostatic activity. Free Radic Biol Med 1994, 17: 45-64. 10.1016/0891-5849(94)90007-8CrossRefPubMed
6.
go back to reference Suliman HB, Welty-Wolf KE, Carraway MS, Tatro L, Pianttadosi CA: Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res 2004, 64: 279-288. 10.1016/j.cardiores.2004.07.005CrossRefPubMed Suliman HB, Welty-Wolf KE, Carraway MS, Tatro L, Pianttadosi CA: Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Cardiovasc Res 2004, 64: 279-288. 10.1016/j.cardiores.2004.07.005CrossRefPubMed
7.
go back to reference Frost MT, Wang Q, Moncada S, Singer M: Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex 1 in activated macrophages. Am J Physiol Regul Integr Comp Physiol 2005, 288: R394-R400.CrossRefPubMed Frost MT, Wang Q, Moncada S, Singer M: Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex 1 in activated macrophages. Am J Physiol Regul Integr Comp Physiol 2005, 288: R394-R400.CrossRefPubMed
8.
go back to reference Heyland DK, Dhaliwal R, Day A, Drover J, Cote H, Wischmeyer P: Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. J Parenteral Enteral Nutr 2007, 31: 109-118.CrossRef Heyland DK, Dhaliwal R, Day A, Drover J, Cote H, Wischmeyer P: Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. J Parenteral Enteral Nutr 2007, 31: 109-118.CrossRef
9.
go back to reference Heyland DK, Dhaliwal R, Day AG, Muscedere J, Drover J, Suchner U, Cook D, Canadian Critical Care Trials Group: REducing Deaths due to OXidative Stress (The REDOXS Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc 2006, 65: 250-263.CrossRefPubMed Heyland DK, Dhaliwal R, Day AG, Muscedere J, Drover J, Suchner U, Cook D, Canadian Critical Care Trials Group: REducing Deaths due to OXidative Stress (The REDOXS Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc 2006, 65: 250-263.CrossRefPubMed
10.
go back to reference Berger MM, Spertini F, Shenkin A, Wardle C, Wiesner L, Schindler C, Chioléro RL: Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998, 68: 365-371.PubMed Berger MM, Spertini F, Shenkin A, Wardle C, Wiesner L, Schindler C, Chioléro RL: Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998, 68: 365-371.PubMed
11.
go back to reference Porter JM, Ivatury RR, Azimuddin K, Swami R: Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: early results of a prospective randomized study. Am Surg 1999, 65: 478-483.PubMed Porter JM, Ivatury RR, Azimuddin K, Swami R: Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: early results of a prospective randomized study. Am Surg 1999, 65: 478-483.PubMed
12.
go back to reference Berger MM, Baines M, Wardle CA, Cayeux MC, Chiolero R, Shenkin A: Trace element supplements modulate tissue levels, antioxidant status and clinical course after major burns – preliminary results. Clin Nutr 2002,21(Suppl 1):66. Berger MM, Baines M, Wardle CA, Cayeux MC, Chiolero R, Shenkin A: Trace element supplements modulate tissue levels, antioxidant status and clinical course after major burns – preliminary results. Clin Nutr 2002,21(Suppl 1):66.
13.
go back to reference Berger MM, Recmond MJ, Shenkin A, Rey F, Wardle C, Cayeux C, Schindler C, Chiolero : Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med 2001, 27: 91-100. 10.1007/s001340000757CrossRefPubMed Berger MM, Recmond MJ, Shenkin A, Rey F, Wardle C, Cayeux C, Schindler C, Chiolero : Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med 2001, 27: 91-100. 10.1007/s001340000757CrossRefPubMed
14.
go back to reference Kuklinski B, Buchner M, Schweder R, Nagel R: Akute Pancreatitis-eine "Free Radical Disease:. Letalitatssenkung durch Natriumselenit (Na2SeO3)-Therapie. Z Gestame Inn Med 1991, 46: S145-149. Kuklinski B, Buchner M, Schweder R, Nagel R: Akute Pancreatitis-eine "Free Radical Disease:. Letalitatssenkung durch Natriumselenit (Na2SeO3)-Therapie. Z Gestame Inn Med 1991, 46: S145-149.
15.
go back to reference Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R: Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med 1999, 27: 1807-1813. 10.1097/00003246-199909000-00017CrossRefPubMed Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R: Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med 1999, 27: 1807-1813. 10.1097/00003246-199909000-00017CrossRefPubMed
16.
go back to reference Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, et al.: Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 2007, 35: 118-26. 10.1097/01.CCM.0000251124.83436.0ECrossRefPubMed Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, et al.: Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 2007, 35: 118-26. 10.1097/01.CCM.0000251124.83436.0ECrossRefPubMed
17.
go back to reference Zimmermann T, Albrecht S, Kühne H, Vogelsang U, Grützmann R, Kopprasch S: Selensubstitution bei Sepsispatienten. Med Klin 1997,92(Suppl III):3-4.CrossRef Zimmermann T, Albrecht S, Kühne H, Vogelsang U, Grützmann R, Kopprasch S: Selensubstitution bei Sepsispatienten. Med Klin 1997,92(Suppl III):3-4.CrossRef
Metadata
Title
Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?
Author
Daren K Heyland
Publication date
01-08-2007
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2007
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5975

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