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01-12-2006 | Review

Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics

Authors: Eric B Milbrandt, Derek C Angus

Published in: Critical Care | Issue 6/2006

Abstract

Cognitive dysfunction is common in critically ill patients, not only during the acute illness but also long after its resolution. A large number of pathophysiologic mechanisms are thought to underlie critical illness-associated cognitive dysfunction, including neuro-transmitter abnormalities and occult diffuse brain injury. Markers that could be used to evaluate the influence of specific mechanisms in individual patients include serum anticholinergic activity, certain brain proteins, and tissue sodium concentration determination via high-resolution three-dimensional magnetic resonance imaging. Although recent therapeutic advances in this area are exciting, they are still too immature to influence patient care. Additional research is needed if we are to understand better the relative contributions of specific mechanisms to the development of critical illness-associated cognitive dysfunction and to determine whether these mechanisms might be amenable to treatment or prevention.

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Title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics
Authors: Eric B Milbrandt
Derek C Angus
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Critical Care / Issue 6/2006
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc5078

At a glance: The STEP trials

Springer Medicine

Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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