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Critical Care
Published in: Critical Care 4/2006

01-08-2006 | Review

Bench-to-bedside review: Genetics and proteomics: deciphering gene association studies in critical illness

Authors: Sachin Yende, Candace M Kammerer, Derek C Angus

Published in: Critical Care | Issue 4/2006

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Abstract

There is considerable interest in understanding genetic determinants of critical illness to improve current risk stratification models, provide individualized therapies, and improve our current understanding of disease mechanisms. This review provides a broad overview of genetic nomenclature, different study designs, and problems unique to each of these study designs in critical illnesses. Well designed genetic studies with careful attention to these issues during the planning phase, use of rigorous statistical methods during analysis, and replication of these results in different cohorts will lead to more robust results and improved understanding of genetics of critical care.
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Metadata
Title
Bench-to-bedside review: Genetics and proteomics: deciphering gene association studies in critical illness
Authors
Sachin Yende
Candace M Kammerer
Derek C Angus
Publication date
01-08-2006
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2006
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5015

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