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Critical Care
Published in: Critical Care 1/2006

01-02-2006 | Letter

Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients

Authors: Paolo Manzoni, Daniele Farina, MariaLisa Leonessa, Claudio Priolo, Giovanna Gomirato

Published in: Critical Care | Issue 1/2006

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Excerpt

We read with great interest the recent article by Ho and coworkers [1] concerning the use of prophylactic fluconazole in high-risk surgical patients, in which those authors reported on seven randomized controlled studies from the Cochrane Controlled Trial Register. Ho and colleagues concluded that the use of prophylactic fluconazole in immunocompetent high-risk surgical patients is associated with a reduced incidence of candidaemia, fewer patients requiring systemic amphotericin B as rescue therapy for systemic fungal infection, and no increase in the proportion of patients colonized with or infected with fluconazole-resistant fungi, but with only a trend toward a reduction in hospital mortality. …
Literature
1.
Ho KM, Lipman J, Dobb GJ, Webb SAR: The use of prophylactic fluconazole in immunocompetent high-risk surgical patients: a meta-analysis. Crit Care 2005, 9: R710-R717. 10.1186/cc3883PubMedCentralCrossRefPubMed
2.
Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Donowitz LG: Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med 2001, 345: 1660-1666. 10.1056/NEJMoa010494CrossRefPubMed
3.
Kicklighter SD, Springer SC, Cox T, Hulsey TC, Turner RB: Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant. Paediatrics 2001, 107: 293-298. 10.1542/peds.107.2.293CrossRef
4.
Manzoni P, Arisio R, Mostert M, Leonessa M, Farina D, Latino MA, Gomirato G: Prophylactic Fluconazole Is Effective in Preventing Fungal Colonization and Fungal Systemic Infections in Preterm Neonates: A Single-Center, 6-Year, Retrospective Cohort Study. Pediatrics, in press. 2005, Dec 1
5.
Long SS, Stevenson DK: Reducing Candida infections during neonatal intensive care: management choices, infection control, and fluconazole prophylaxis. J Pediatr 2005, 147: 135-141. 10.1016/j.jpeds.2005.04.033CrossRefPubMed
Metadata
Title
Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients
Authors
Paolo Manzoni
Daniele Farina
MariaLisa Leonessa
Claudio Priolo
Giovanna Gomirato
Publication date
01-02-2006
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2006
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3958

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