Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 6/2005

01-12-2005 | Commentary

The place of early haemoperfusion with polymyxin B fibre column in the treatment of sepsis

Author: Claudio Ronco

Published in: Critical Care | Issue 6/2005

Login to get access

Abstract

Direct haemoperfusion with polymyxin B-immobilized fibre (PMX-F) is a promising treatment for Gram-negative sepsis in critically ill patients. Indeed, it has been used routinely in Japan for a decade. Recent evidence presented in this journal suggests that PMX-F can have a positive impact on outcome in patients with sepsis, although other reports in the literature have presented confusing or even conflicting results. This commentary considers whether the available evidence allows us to establish an appropriate role for PMX-F treatment in sepsis and what further work is needed.
Literature
1.
Kushi H, Miki T, Okamaoto K, Nakahara J, Saito T, Tanjoh K: Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. Crit Care 2005, 9: R653-R661. 10.1186/cc3815PubMedCentralCrossRefPubMed
2.
Uriu K, Osajima A, Kamochi M, Watanabe H, Aibara K, Kaizu K: The severity of hyperdynamic circulation may predict the effects of direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber in patients with Gram-negative septic shock. Ther Apher 2001, 5: 25-30. 10.1046/j.1526-0968.2001.005001025.xCrossRefPubMed
3.
Nemoto H, Nakamoto H, Okada H, Sugahara S, Moriwaki K, Arai M, Kanno Y, Suzuki H: Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif 2001, 19: 361-369. 10.1159/000046966CrossRefPubMed
4.
Suzuki H, Nemoto H, Nakamoto H, Okada H, Sugahara S, Kanno Y, Moriwaki K: Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure. Ther Apher 2002, 6: 234-240. 10.1046/j.1526-0968.2002.00416.xCrossRefPubMed
5.
Shoji H: Extracorporeal endotoxin removal for the treatement of sepsis: endotoxin adsorbtion cartridge (Toraymyxin). Ther Apher Dial 2003, 7: 108-114. 10.1046/j.1526-0968.2003.00005.xCrossRefPubMed
6.
Vincent Jl, Laterre PF, Cohen J, Burchardi H, Bruining H, Lerma FA, Wittebole X, De Backer D, Brett S, Marzo D, et al.: A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 2005, 23: 400-405. 10.1097/01.shk.0000159930.87737.8aCrossRefPubMed
7.
Tsuzuki H, Tani T, Ueyama H, Kodama M: Lipopolysaccharide: neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappab in peripheral blood mononuclear cells, even during activation. J Surg Res 2001, 100: 127-134. 10.1006/jsre.2001.6227CrossRefPubMed
8.
Uriu K, Osajima A, Kamochi M, Watanabe H, Aibara K, Kaizu K: The severity of hyperdynamic circulation may predict the effects of direct hemoperfusion with the adsorbent column using polymyxin B-immobilized fiber in patients with Gram-negative septic shock. Ther Apher 2001, 5: 25-30. 10.1046/j.1526-0968.2001.005001025.xCrossRefPubMed
9.
Ronco C, Brendolan A, Scabardi M, Ronco F, Nakamura H: Blood flow distribution in a polymyxin B coated fibrous bed for endotoxin removal. Effect of a new blood path design. Int J Artif Organs 2001, 24: 167-172.PubMed
10.
Wang Y, Liu Y, Sarker KP, Nakashima M, Serizawa T, Kishida A, Akashi M, Nakata M, Kitajima I, Maruyama I: Polymyxin B binds to anandamide and inhibits its cytotoxic effect. FEBS Lett 2000, 470: 151-155. 10.1016/S0014-5793(00)01313-2CrossRefPubMed
11.
Nakamura T, Kawagoe Y, Matsuda T, Ebihara I, Koide H: Effects of polymyxin B-immobilized fiber hemoperfusion on amino acid imbalance in septic encephalopathy. Blood Purif 2003, 21: 282-286. 10.1159/000072546CrossRefPubMed
Metadata
Title
The place of early haemoperfusion with polymyxin B fibre column in the treatment of sepsis
Author
Claudio Ronco
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3890

Other articles of this Issue 6/2005

Critical Care 6/2005 Go to the issue

Review

Lactate as a marker of energy failure in critically ill patients: hypothesis

Research

Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation

Commentary

The staging of sepsis: understanding heterogeneity in treatment efficacy

Research

The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study

Review

Functional hemodynamic monitoring

Research

Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study