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Critical Care
Published in: Critical Care 6/2005

Open Access 01-12-2005 | Research

Early veno-venous haemodiafiltration for sepsis-related multiple organ failure

Authors: Bernard Page, Antoine Vieillard-Baron, Karim Chergui, Olivier Peyrouset, Anne Rabiller, Alain Beauchet, Philippe Aegerter, François Jardin

Published in: Critical Care | Issue 6/2005

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Abstract

Introduction

We conducted a prospective observational study from January 1995 to December 2004 to evaluate the impact on recovery of a major advance in renal replacement therapy, namely continuous veno-venous haemodiafiltration (CVVHDF), in patients with refractory septic shock.

Method

CVVHDF was implemented after 6–12 hours of maximal haemodynamic support, and base excess monitoring was used to evaluate the improvement achieved. Of the 60 patients studied, 40 had improved metabolic acidosis after 12 hours of CVVHDF, with a progressive improvement in all failing organs; the final mortality rate in this subgroup was 30%. In contrast, metabolic acidosis did not improve in the remaining 20 patients after 12 hours of CVVHDF, and the mortality rate in this subgroup was 100%. The crude mortality rate for the whole group was 53%, which is significantly lower than the predicted mortality using Simplified Acute Physiology Score II (79%).

Conclusion

Early CVVHDF may improve the prognosis of sepsis-related multiple organ failure. Failure to correct metabolic acidosis rapidly during the procedure was a strong predictor of mortality.
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Metadata
Title
Early veno-venous haemodiafiltration for sepsis-related multiple organ failure
Authors
Bernard Page
Antoine Vieillard-Baron
Karim Chergui
Olivier Peyrouset
Anne Rabiller
Alain Beauchet
Philippe Aegerter
François Jardin
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3886

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