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Open Access 01-10-2005 | Research

Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection

Authors: Michael Siassi, Jutta Riese, Rudi Steffensen, Michael Meisner, Steffen Thiel, Werner Hohenberger, Joachim Schmidt

Published in: Critical Care | Issue 5/2005

Abstract

Introduction

Postoperative infection is a major cause of morbidity and mortality. We investigated two serum markers for their ability to identify patients at risk for postoperative infection. Mannan-binding lectin (MBL) is a central molecule of the innate immune system and MBL deficiency is known to predispose to infection. Procalcitonin (PCT) is a sensitive marker for bacterial infection.

Methods

We investigated 162 patients undergoing elective surgery for cancer of the gastrointestinal tract. Patients were classified as having no complications (group A), having infection for unknown reason (group B) or having sepsis after events like aspiration or anastomotic leakage (group C). Analysis was done pre- and postoperatively for serum levels of MBL, PCT and C-reactive-protein. DNA was preoperatively sampled and stored and later analysed for genetic polymorphisms of MBL.

Results

The preoperative serum levels of MBL were significantly lower in group B patients than in group A patients (1332 ± 466 ng/ml versus 2523 ± 181 ng/ml). PCT measured on day one post-surgery was significantly higher in group B patients than in group A (3.33 ± 1.08 ng/ml versus 1.38 ± 0.17 ng/ml). Patients with an aberrant MBL genotype had a significantly higher risk of postoperative infections than wild-type carriers (p < 0.05).

Conclusion

Preoperative MBL and early postoperative PCT measurement may help identify patients at risk for postoperative infection.

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Title: Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection
Authors: Michael Siassi
Jutta Riese
Rudi Steffensen
Michael Meisner
Steffen Thiel
Werner Hohenberger
Joachim Schmidt
Publication date: 01-10-2005
Publisher: BioMed Central
Published in: Critical Care / Issue 5/2005
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc3768

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Mannan-binding lectin and procalcitonin measurement for prediction of postoperative infection

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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