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Critical Care
Published in: Critical Care 5/1999

01-10-1999 | Review

Blood substitutes

Author: DonatR Spahn

Published in: Critical Care | Issue 5/1999

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Excerpt

Blood substitutes have long been sought after, and artificial oxygen carriers may soon become a reality. Despite increased safety of allogeneic blood in terms of transmission of infectious diseases [1], avoiding allogeneic blood transfusions remains an important goal in perioperative and intensive care medicine. This is because allogeneic blood transfusions may cause immunosuppression with an increased incidence of postoperative infections [2,3] and may adversely affect outcome in intensive care [4], and thus they remain a public concern [5]. …
Literature
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Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine. First of two parts - blood transfusion. N Engl J Med 1999, 340: 438-447. 10.1056/NEJM199902113400606CrossRefPubMed
2.
Spahn DR, Leone BJ, Reves JG, Pasch T: Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions. Anesth Analg 1994, 78: 1000-1021.CrossRefPubMed
3.
Spahn DR, Schmid ER: Haemodilution in cardiac and vascular surgery. Curr Opin Anaesthesiol 1996, 9: 54-61.CrossRef
4.
Hebert PC, Wells G, Blajchman MA, et al.: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999, 340: 409-417. 10.1056/NEJM199902113400601CrossRefPubMed
5.
Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine. Second of two parts - blood conservation. N Engl J Med 1999, 340: 525-533. 10.1056/NEJM199902183400706CrossRefPubMed
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Keipert PE: Perfluorochemical emulsions: future alternatives to transfusion. Blood Subst Princ Meth Prod Clin Trials 1998, 2: 127-156.
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Frietsch T, Lenz C, Waschke KF: Artificial oxygen carriers. Eur J Anaesth 1998, 15: 571-584. 10.1046/j.1365-2346.1998.00356.xCrossRef
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Chang TM: Artificial cells with emphasis on cell encapsulation of genetically engineered cells. Artif Organs 1998, 22: 958-965. 10.1046/j.1525-1594.1998.06243.xCrossRefPubMed
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Chang TM: Modified hemoglobin-based blood substitutes: crosslinked, recombinant and encapsulated hemoglobin. Vox Sang 1998, 74 (suppl 2): 233-241.CrossRef
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Gould SA, Moss GS: Clinical development of human polymerized hemoglobin as a blood substitute. World J Surg 1996, 20: 1200-1207. 10.1007/s002689900183CrossRefPubMed
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Spahn DR, van Bremt R, Theilmeier G, et al.: Perflubron emulsion delays blood transfusion in orthopedic surgery. Anesthesiology 1999, in press.
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A Report by the American Society of Anesthesiologists Task Force on Blood Component Therapy : Practice guidelines for blood component therapy. Anesthesiology 1996, 84: 732-747.CrossRef
Metadata
Title
Blood substitutes
Author
DonatR Spahn
Publication date
01-10-1999
Publisher
BioMed Central
Published in
Critical Care / Issue 5/1999
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc363

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