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Published in: Critical Care 1/2005

01-02-2004 | Commentary

Roundtable debate: Controversies in the management of the septic patient – desperately seeking consensus

Authors: Aaron B Waxman, Nicholas Ward, Taylor Thompson, Craig M Lilly, Alan Lisbon, Nicholas Hill, Stanley A Nasraway, Stephen Heard, Howard Corwin, Mitchell Levy

Published in: Critical Care | Issue 1/2005

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Abstract

Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the underlying infection. There is a substantial body of knowledge indicating that fluid resuscitation, vasopressors, and antibiotics accomplish these goals. Recent clinical trials have provided new information on the addition of individual adjuvant therapies. Consensus on how current therapies should be prescribed is lacking. We present the reasoning and preferences of a group of intensivists who met to discuss the management of an actual case. The focus is on management, with emphasis on the criteria by which treatment decisions are made. It is clear from the discussion that there are areas where there is agreement and areas where opinions diverge. This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine.
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Literature
1.
go back to reference Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002CrossRefPubMed Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002CrossRefPubMed
2.
go back to reference Hollenberg SM, Aherns TS, Astiz ME, Chalfin DB, Dasta JF, Heard SO, Martin C, Sulsa GM, Vincent JL: Practice parameters for hemodynamic support of sepsis in adult patients. Crit Care Med 1999, 27: 639-660.CrossRef Hollenberg SM, Aherns TS, Astiz ME, Chalfin DB, Dasta JF, Heard SO, Martin C, Sulsa GM, Vincent JL: Practice parameters for hemodynamic support of sepsis in adult patients. Crit Care Med 1999, 27: 639-660.CrossRef
3.
go back to reference Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE: The coronary circulation in human septic shock. Circulation 1986, 73: 637-644.CrossRefPubMed Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE: The coronary circulation in human septic shock. Circulation 1986, 73: 637-644.CrossRefPubMed
4.
go back to reference Ellrodt AG, Riedinger MS, Kimchi A: Left ventricular performance in septic shock: reversible segmental and global abnormalities. Am Heart J 1985, 110: 402-409. 10.1016/0002-8703(85)90163-2CrossRefPubMed Ellrodt AG, Riedinger MS, Kimchi A: Left ventricular performance in septic shock: reversible segmental and global abnormalities. Am Heart J 1985, 110: 402-409. 10.1016/0002-8703(85)90163-2CrossRefPubMed
5.
go back to reference Raper RF, Sibbald WJ, Hobson J, Neal A, Cheung H: Changes in myocardial blood flow rates during hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need. Crit Care Med 1993, 21: 1192-1199.CrossRefPubMed Raper RF, Sibbald WJ, Hobson J, Neal A, Cheung H: Changes in myocardial blood flow rates during hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need. Crit Care Med 1993, 21: 1192-1199.CrossRefPubMed
6.
go back to reference Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortso E, Ording H, Lindorff-Larsen K, Rasmussen MS, Lanng C, Wallin L, The Danish Study Group on Perioperative Fluid Therapy: Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg 2003, 238: 641-648. 10.1097/01.sla.0000094387.50865.23PubMedCentralCrossRefPubMed Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortso E, Ording H, Lindorff-Larsen K, Rasmussen MS, Lanng C, Wallin L, The Danish Study Group on Perioperative Fluid Therapy: Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg 2003, 238: 641-648. 10.1097/01.sla.0000094387.50865.23PubMedCentralCrossRefPubMed
7.
go back to reference Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345: 1368-1377. 10.1056/NEJMoa010307CrossRefPubMed Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345: 1368-1377. 10.1056/NEJMoa010307CrossRefPubMed
8.
go back to reference Annane D, Sebille V, Charpentier C, Bollaert P-E, Francois B, Korach J-M, Capellier G, Cohen Y, Azoulay E, Troche G, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288: 862-871. 10.1001/jama.288.7.862CrossRefPubMed Annane D, Sebille V, Charpentier C, Bollaert P-E, Francois B, Korach J-M, Capellier G, Cohen Y, Azoulay E, Troche G, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288: 862-871. 10.1001/jama.288.7.862CrossRefPubMed
9.
go back to reference Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E: A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000, 283: 1038-1045. 10.1001/jama.283.8.1038CrossRefPubMed Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E: A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000, 283: 1038-1045. 10.1001/jama.283.8.1038CrossRefPubMed
10.
go back to reference Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut J-F, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344: 699-709. 10.1056/NEJM200103083441001CrossRefPubMed Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut J-F, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al.: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344: 699-709. 10.1056/NEJM200103083441001CrossRefPubMed
11.
go back to reference Levy MM, Macias WL, Russell JA, Williams MD, Trzaskoma BL, Silva E, Vincent J-L: Failure to improve during first day of therapy is predictive of 28-day mortality in severe sepsis. Chest 2003, 124: 120S-123S.CrossRef Levy MM, Macias WL, Russell JA, Williams MD, Trzaskoma BL, Silva E, Vincent J-L: Failure to improve during first day of therapy is predictive of 28-day mortality in severe sepsis. Chest 2003, 124: 120S-123S.CrossRef
Metadata
Title
Roundtable debate: Controversies in the management of the septic patient – desperately seeking consensus
Authors
Aaron B Waxman
Nicholas Ward
Taylor Thompson
Craig M Lilly
Alan Lisbon
Nicholas Hill
Stanley A Nasraway
Stephen Heard
Howard Corwin
Mitchell Levy
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2940

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