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Critical Care
Published in: Critical Care 1/2004

01-02-2004 | Poster presentation

Blood flow and oxygen extraction fraction in regions of oedema following head injury

Authors: P Bradley, S Harding, J Coles, D Chatfield, J Pickard, D Menon

Published in: Critical Care | Special Issue 1/2004

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Excerpt

Cerebral blood flow (CBF) is reduced around areas of contused brain after head injury [1]. However, since the cerebral metabolism is also reduced this may represent appropriate flow-metabolism coupling, rather than ischaemia. Matching of CBF to metabolism is quantified as the oxygen extraction fraction (OEF). We performed magnetic resonance imaging (MRI) and Oxygen 15 positron emission tomography (O-PET) to quantify CBF and OEF in regions of pericontusional oedema after head injury. …
Literature
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Steiner LA, Czosnyka M: Should we measure cerebral blood flow in head-injured patients? Br J Neurosurg 2002, 16: 429-439. 10.1080/0268869021000030221CrossRefPubMed
2.
Hawkes DJ, Hill DL: Medical imaging at Guy's Hospital, King's College London. IEEE Trans Med Imaging 2003, 22: 1033-1041. 10.1109/TMI.2003.815866CrossRefPubMed
3.
Coles JP, et al.: Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology. J Cerebral Blood Flow Metab 2004, 24: 191-202. 10.1097/01.WCB.0000100045.07481.DECrossRef
4.
Marchal G, Benali K, Iglesias S, Viader F, Derlon J-M, Baron J-C: Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke. Brain 1999, 122: 2387-2400. 10.1093/brain/122.12.2387CrossRefPubMed
Metadata
Title
Blood flow and oxygen extraction fraction in regions of oedema following head injury
Authors
P Bradley
S Harding
J Coles
D Chatfield
J Pickard
D Menon
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2004
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2778

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