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Open Access 01-06-2014 | Review

Management of anticoagulant-related intracranial hemorrhage: an evidence-based review

Authors: Bappaditya Ray, Salah G Keyrouz

Published in: Critical Care | Issue 3/2014

Abstract

The increased use of anticoagulants for the prevention and treatment of thromboembolic diseases has led to a rising incidence of anticoagulant-related intracranial hemorrhage (AICH) in the aging western population. High mortality accompanies this form of hemorrhagic stroke, and significant and debilitating long-term consequences plague survivors. Although management guidelines for such hemorrhages are available for the older generation anticoagulants, they are still lacking for newer agents, which are becoming popular among physicians. Supportive care, including blood pressure control, and reversal of anticoagulation remain the cornerstone of acute management of AICH. Prothrombin complex concentrates are gaining popularity over fresh frozen plasma, and reversal agents for newer anticoagulation agents are being developed. Surgical interventions are options fraught with complications, and are decided on a case-by-case basis. Our current state of understanding of this condition and its management is insufficient. This deficit calls for more population-based studies and therapeutic trials to better evaluate risk factors for, and to prevent and treat AICH.

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Title: Management of anticoagulant-related intracranial hemorrhage: an evidence-based review
Authors: Bappaditya Ray
Salah G Keyrouz
Publication date: 01-06-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc13889

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Management of anticoagulant-related intracranial hemorrhage: an evidence-based review

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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