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Critical Care
Published in: Critical Care 2/2014

01-04-2014 | Letter

The renal angiopoietin/Tie2 system in lethal human sepsis

Authors: Adnan Aslan, Rianne M Jongman, Jill Moser, Coen A Stegeman, Harry van Goor, Arjan Diepstra, Marius C van den Heuvel, Peter Heeringa, Grietje Molema, Jan G Zijlstra, Matijs van Meurs

Published in: Critical Care | Issue 2/2014

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Excerpt

Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults [1]. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking [2‐5]. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized. …
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Literature
1.
van Meurs M, Kumpers P, Ligtenberg JJ, Meertens JH, Molema G, Zijlstra JG: Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target? Crit Care 2009, 13: 207. 10.1186/cc7153PubMedCentralCrossRefPubMed
2.
Kumpers P, Lukasz A, David S, Horn R, Hafer C, Faulhaber-Walter R, Fliser D, Haller H, Kielstein JT: Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care 2008, 12: R147. 10.1186/cc7130PubMedCentralCrossRefPubMed
3.
van Meurs M, Wulfert FM, Knol AJ, de Haes A, Houwertjes M, Aarts LP, Molema G: Early organ-specific endothelial activation during hemorrhagic shock and resuscitation. Shock 2008, 29: 291-299.PubMed
4.
van Meurs M, Kurniati NF, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kümpers P, Zijlstra JG, Heeringa P, Molema G: Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function. Am J Physiol Renal Physiol 2009, 297: F272-F281. 10.1152/ajprenal.00137.2009CrossRefPubMed
5.
Kurniati NF, Jongman RM, Vom Hagen F, Spokes KC, Moser J, Regan ER, Krenning G, Moonen JR, Harmsen MC, Struys MM, Hammes HP, Zijlstra JG, Aird WC, Heeringa P, Molema G, van Meurs M: The flow dependency of Tie2 expression in endotoxemia. Intensive Care Med 2013, 39: 1262-1271. 10.1007/s00134-013-2899-7CrossRefPubMed
Metadata
Title
The renal angiopoietin/Tie2 system in lethal human sepsis
Authors
Adnan Aslan
Rianne M Jongman
Jill Moser
Coen A Stegeman
Harry van Goor
Arjan Diepstra
Marius C van den Heuvel
Peter Heeringa
Grietje Molema
Jan G Zijlstra
Matijs van Meurs
Publication date
01-04-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13806

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