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Critical Care
Published in: Critical Care 2/2014

01-04-2014 | Letter

Impairment of hepatocellular excretory function, sepsis and liver insufficiency after liver resection

Authors: Carlo Chiarla, Ivo Giovannini, Francesco Ardito, Maria Vellone, Gennaro Nuzzo, Felice Giuliante

Published in: Critical Care | Issue 2/2014

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Excerpt

We appreciated the article by Gonnert and colleagues on hyperbilirubinemia from septic hepatocellular excretory dysfunction [1], a still improperly characterized issue in clinical settings. We address postoperative liver resection patients with prominently conjugated (~50 to 70 % conjugated) hyperbilirubinemia. Less relevant causes include transient insufficiency of remnant liver and prolonged intraoperative ischemia [2]; a threatening cause is occult sepsis. …
Literature
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Gonnert FA, Recknagel P, Hilger I, Claus RA, Bauer M, Kortgen A: Hepatic excretory function in sepsis: implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model. Crit Care 2013, 17: R67. 10.1186/cc12606PubMedCentralCrossRefPubMed
2.
Chiarla C, Giovannini I, Giuliante F, Vellone M, Ardito F, Masi A, Nuzzo G: Plasma bilirubin correlations in non-obstructive cholestasis after partial hepatectomy. Clin Chem Lab Med 2008, 46: 1598-1601.CrossRefPubMed
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Nuzzo G, Giovannini I, Giuliante F, Ardito F, Chiarla C: Sepsis after liver resection: predisposition, clinical relevance and synergism with liver dysfunction. In Recent Advances in Liver Surgery. Edited by: Dionigi R. Austin, TX: Landes Bioscience; 2009:245-259.
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Giovannini I, Chiarla C, Giuliante F, Vellone M, Ardito F, Sarno G, Nuzzo G: Analysis of the components of hypertransaminasemia after liver resection. Clin Chem Lab Med 2007, 45: 357-360.PubMed
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Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carre JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M: Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med 2012, 9: e1001338. 10.1371/journal.pmed.1001338PubMedCentralCrossRefPubMed
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Kortgen A, Paxian M, Werth M, Recknagel P, Rauchfuss F, Lupp A, Krenn CG, Muller D, Claus RA, Reinhart K, Settmacher U, Bauer M: Prospective assessment of hepatic function and mechanisms of dysfunction in the critically ill. Shock 2009, 32: 358-365. 10.1097/SHK.0b013e31819d8204CrossRefPubMed
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Kaffarnik MF, Lock JF, Vetter H, Ahmadi N, Lojewski C, Malinowski M, Neuhaus P, Stockmann M: Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test. Crit Care 2013, 17: R259. 10.1186/cc13089PubMedCentralCrossRefPubMed
Metadata
Title
Impairment of hepatocellular excretory function, sepsis and liver insufficiency after liver resection
Authors
Carlo Chiarla
Ivo Giovannini
Francesco Ardito
Maria Vellone
Gennaro Nuzzo
Felice Giuliante
Publication date
01-04-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13792

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