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Critical Care
Published in: Critical Care 2/2014

01-04-2014 | Letter

Gender-specific differences in outcome after trauma may be explained by differences in immunity

Authors: LucasT van Eijk, Matthijs Kox, Peter Pickkers

Published in: Critical Care | Issue 2/2014

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Excerpt

With great interest we read the article by Dr Schoeneberg and colleagues regarding gender-specific differences with respect to outcome in patients with severe traumatic injury. The authors show that, apart from the acute phase after trauma, women have a more favorable trauma severity-adjusted outcome, with shorter ICU and hospital stay and lower sepsis rates [1]. However, a possible mechanism of action behind this difference was not suggested. We hypothesize that, in view of the fact that morbidity and mortality in the post-acute phase after trauma are often caused by infectious complications [2], gender differences in immunity might explain the observed differences. …
Literature
1.
Schoeneberg C, Kauther MD, Hussmann B, Keitel J, Schmitz D, Lendemans S: Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis. Crit Care 2013, 17: R277. 10.1186/cc13132PubMedCentralCrossRefPubMed
2.
Hietbrink F, Koenderman L, Rijkers G, Leenen L: Trauma: the role of the innate immune system. World J Emergency Surg 2006, 1: 15. 10.1186/1749-7922-1-15CrossRef
3.
van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P: Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med 2007, 35: 1464-1469. 10.1097/01.CCM.0000266534.14262.E8CrossRefPubMed
4.
Netea MG, van der Meer JW, van Deuren M, Kullberg BJ: Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends Immunol 2003, 24: 254-258. 10.1016/S1471-4906(03)00079-6CrossRefPubMed
5.
Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P: Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 2013, 187: 1287-1293. 10.1164/rccm.201301-0036CPCrossRefPubMed
6.
Sperry JL, Nathens AB, Frankel HL, Vanek SL, Moore EE, Maier RV, Minei JP, Inflammation and the Host Response to Injury Investigators: Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med 2008, 36: 1838-1845. 10.1097/CCM.0b013e3181760c14CrossRefPubMed
Metadata
Title
Gender-specific differences in outcome after trauma may be explained by differences in immunity
Authors
LucasT van Eijk
Matthijs Kox
Peter Pickkers
Publication date
01-04-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13768

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