Top

Published in:

01-02-2014 | Letter

Circulating neutrophil counts and mortality in septic shock

Authors: Jesús F Bermejo-Martín, Eduardo Tamayo, Gema Ruiz, David Andaluz-Ojeda, Rubén Herrán-Monge, Arturo Muriel-Bombín, Maria Fe Muñoz, María Heredia-Rodríguez, Rafael Citores, José Ignacio Gómez-Herreras, Jesús Blanco, for the EXPRESS (Expresión Génica en Sepsis) and GRECIA (Grupo de Estudios y Análisis en Cuidados Intensivos) groups

Published in: Critical Care | Issue 1/2014

Excerpt

Polynuclear neutrophils can play dual roles in sepsis: on the one hand they mediate major antimicrobial activities and on the other hand they can contribute to the development of multiple organ failure [1]. Nonetheless, in spite of the importance of these cells in sepsis, the influence of the circulating neutrophil count (CNC) on the prognosis of septic patients with this pathology has not been properly evaluated. …

Available only for authorised users

Brown KA, Brain SD, Pearson JD, Edgeworth JD, Lewis SM, Treacher DF: Neutrophils in development of multiple organ failure in sepsis. Lancet 2006, 368: 157-169. 10.1016/S0140-6736(06)69005-3CrossRefPubMed

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ, ACCP/SCCM Consensus Conference Committee: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 2009, 136: e28. 10.1378/chest.09-2267CrossRefPubMed

Lim E-M, Cembrowski G, Cembrowski M, Clarke G: Race-specific WBC and neutrophil count reference intervals. Int J Lab Hematol 2010, 32: 590-597. 10.1111/j.1751-553X.2010.01223.xCrossRefPubMed

Fox ED, Heffernan DS, Cioffi WG, Reichner JS: Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity. Crit Care 2013, 17: R226. 10.1186/cc13049PubMedCentralCrossRefPubMed

Brown KA, Treacher DF: Neutrophils as potential therapeutic targets in sepsis. Discov Med 2006, 6: 118-122.PubMed

Title: Circulating neutrophil counts and mortality in septic shock
Authors: Jesús F Bermejo-Martín
Eduardo Tamayo
Gema Ruiz
David Andaluz-Ojeda
Rubén Herrán-Monge
Arturo Muriel-Bombín
Maria Fe Muñoz
María Heredia-Rodríguez
Rafael Citores
José Ignacio Gómez-Herreras
Jesús Blanco
for the EXPRESS (Expresión Génica en Sepsis) and GRECIA (Grupo de Estudios y Análisis en Cuidados Intensivos) groups
Publication date: 01-02-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc13728

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Circulating neutrophil counts and mortality in septic shock

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2014

Preventing deaths related to percutaneous tracheostomy: safety is never too much!

Angiogenic factors in sepsis: are we ready for the new therapeutic era?

Extracorporeal membrane oxygenation in adult patients with hematologic malignancies and severe acute respiratory failure

The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial

Implementing evidence-based practice in the neuroscience intensive care unit

The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials