Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 5/2013

01-10-2013 | Letter

3,4-Diaminopyridine may improve neuromuscular block during botulism

Authors: Arnaud Friggeri, Frédéric Marçon, Sandra Marciniak, Anne-Sophie Lemaire-Hurtel, Abdoul Aziz Seydi, Nacim Ammenouche, Mélanie Levrard, Yazine Mahjoub, Norik Airapetian, François Tinturier, Michel Petitjean, Hervé Dupont

Published in: Critical Care | Issue 5/2013

Login to get access

Excerpt

In September 2011, two outbreaks of botulism toxemia (toxin A) incriminating the same artisanal product were responsible for nine cases of botulism in France. Among these cases, three women (Cases 1, 2, and 3) aged 27, 29, and 23 years, respectively, were hospitalized in our ICU for mechanical ventilation support. They rapidly received a trivalent botulism antitoxin serum. Two weeks later, Case 3 passed a spontaneous breathing trial but needed new ventilator support 24 hours after extubation. …
Appendix
Available only for authorised users
Literature
1.
Kongsaengdao S, Samintarapanya K, Rusmeechan S, Wongsa A, Pothirat C, Permpikul C, Pongpakdee S, Puavilai W, Kateruttanakul P, Phengtham U, Panjapornpon K, Janma J, Piyavechviratana K, Sithinamsuwan P, Deesomchok A, Tongyoo S, Vilaichone W, Boonyapisit K, Mayotarn S, Piya-Isragul B, Rattanaphon A, Intalapaporn P, Dusitanond P, Harnsomburana P, Laowittawas W, Chairangsaris P, Suwantamee J, Wongmek W, Ratanarat R, Poompichate A, et al.: An outbreak of botulism in Thailand: clinical manifestations and management of severe respiratory failure. Clin Infect Dis 2006, 43: 1247-1256. 10.1086/508176CrossRefPubMed
2.
Zhang JC, Sun L, Nie QH: Botulism, where are we now? Clin Toxicol (Phila) 2010, 48: 867-879. 10.3109/15563650.2010.535003CrossRef
3.
Adler M, Capacio B, Deshpande SS: Antagonism of botulinum toxin A-mediated muscle paralysis by 3,4-diaminopyridine delivered via osmotic minipumps. Toxicon 2000, 38: 1381-1388. 10.1016/S0041-0101(99)00231-7CrossRefPubMed
4.
McEvoy KM, Windebank AJ, Daube JR, Low PA: 3,4-diaminopyridine in the treatment of Lambert Eaton myasthenic syndrome. N Engl J Med 1989, 321: 1567-1571. 10.1056/NEJM198912073212303CrossRefPubMed
5.
Metadata
Title
3,4-Diaminopyridine may improve neuromuscular block during botulism
Authors
Arnaud Friggeri
Frédéric Marçon
Sandra Marciniak
Anne-Sophie Lemaire-Hurtel
Abdoul Aziz Seydi
Nacim Ammenouche
Mélanie Levrard
Yazine Mahjoub
Norik Airapetian
François Tinturier
Michel Petitjean
Hervé Dupont
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc12880

Other articles of this Issue 5/2013

Critical Care 5/2013 Go to the issue

Research

Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery

Research

Quality of blood culture testing - a survey in intensive care units and microbiological laboratories across four European countries

Commentary

Acute kidney injury: the dilemma of organ failures or just a circular reference?

Commentary

Sleepless nights in the ICU: the awaken family

Research

Clinical prognostic indicators of dysphagia following prolonged orotracheal intubation in ICU patients

Research

Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study