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Critical Care
Published in: Critical Care 2/2013

01-04-2013 | Letter

A human model of intra-abdominal hypertension: even slightly elevated pressures lead to increased acute systemic inflammation and signs of acute kidney injury

Authors: Marije Smit, H Sijbrand Hofker, Henri GD Leuvenink, Christina Krikke, Rianne M Jongman, Jan G Zijlstra, Matijs van Meurs

Published in: Critical Care | Issue 2/2013

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Excerpt

Intra-abdominal hypertension (IAH) may have catastrophic effects on critically ill patients, but its pathophysiology is only partially understood [1]. Oliguria and renal dysfunction are among the earliest signs of increasing intra-abdominal pressure (IAP) [2]. A number of different pathophysiological mechanisms may be responsible [1]. One of these may be an increase in pro-inflammatory cytokines provoked by IAH [2]. In IAPs of greater than 20 mm Hg, an increase in circulating levels of a variety of inflammatory mediators has been described [3]. …
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Literature
1.
Malbrain ML, Vidts W, Ravyts M, De Laet I, De Waele J: Acute intestinal distress syndrome: the importance of intra-abdominal pressure. Minerva Anestesiol 2008, 74: 657-673.PubMed
2.
Mohmand H, Goldfarb S: Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome. J Am Soc Nephrol 2011, 22: 615-621. 10.1681/ASN.2010121222CrossRefPubMed
3.
Rezende-Neto JB, Moore EE, Melo de Andrade MV, Teixeira MM, Lisboa FA, Arantes RM, de Souza DG, da Cunha-Melo JR: Systemic inflammatory response secondary to abdominal compartment syndrome: stage for multiple organ failure. J Trauma 2002, 53: 1121-1128. 10.1097/00005373-200212000-00015CrossRefPubMed
4.
Hofker HS, Nijboer WM, Niesing J, Krikke C, Seelen MA, van Son WJ, van Wijhe M, Groen H, vd Heide JJ, Ploeg RJ: A randomized clinical trial of living donor nephrectomy: a plea for a differentiated appraisal of mini-open muscle splitting incision and hand-assisted laparoscopic donor nephrectomy. Transpl Int 2012, 25: 976-986. 10.1111/j.1432-2277.2012.01525.xCrossRefPubMed
Metadata
Title
A human model of intra-abdominal hypertension: even slightly elevated pressures lead to increased acute systemic inflammation and signs of acute kidney injury
Authors
Marije Smit
H Sijbrand Hofker
Henri GD Leuvenink
Christina Krikke
Rianne M Jongman
Jan G Zijlstra
Matijs van Meurs
Publication date
01-04-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc12568

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