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Critical Care
Published in: Critical Care 2/2012

01-04-2012 | Letter

Arginine metabolism is markedly impaired in polymicrobial infected mice

Authors: Gordon P Otto, Sophie Neugebauer, Ralf A Claus, Maik Sossdorf

Published in: Critical Care | Issue 2/2012

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Excerpt

Since sepsis has been identified as an arginine deficiency state, there is an ongoing controversial debate about arginine supplementation in the treatment of patients with sepsis. Little is known, however, about the different catabolic and anabolic downstream and upstream products or byproducts in arginine metabolism in the course of sepsis. …
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Literature
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Igarashi K, Kashiwagi K: Modulation of cellular function by polyamines. Int J Biochem Cell Biol 2010, 42: 39-51. 10.1016/j.biocel.2009.07.009CrossRefPubMed
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Zhu S, Ashok M, Li J, Li W, Yang H, Wang P, Tracey KJ, Sama AE, Wang H: Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med 2009, 15: 275-282.PubMedCentralPubMed
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Metadata
Title
Arginine metabolism is markedly impaired in polymicrobial infected mice
Authors
Gordon P Otto
Sophie Neugebauer
Ralf A Claus
Maik Sossdorf
Publication date
01-04-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11205

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