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Critical Care
Published in: Critical Care 6/2001

Open Access 01-12-2001 | Research

Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension

Authors: Carmine D Vizza, Giorgio Della Rocca, Di Angelo Roma, Carlo Iacoboni, Federico Pierconti, Federico Venuta, Erino Rendina, Giovanni Schmid, Paolo Pietropaoli, Francesco Fedele

Published in: Critical Care | Issue 6/2001

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Abstract

Introduction

The use of low-dose dobutamine to maintain hemodynamic stability in pulmonary hypertension may have a detrimental effect on gas exchange. The aim of this study was to investigate whether inhaled nitric oxide (INO), dobutamine and a combination of the two have beneficial effects in patients with end-stage airway lung disease and pulmonary hypertension.

Method

Hemodynamic evaluation was assessed 10 min after the administration of each drug and of their combination, in 28 candidates for lung transplantation.

Results

Administration of INO caused a reduction in mean pulmonary arterial pressure (MPAP), an increase in PaO2 with a significant reduction in venous admixture effect (Qs/Qt).Dobutamine administration caused an increase in cardiac index and MPAP, with a decrease in PaO2 as a result of a higher Qs/Qt. Administration of a combination of the two drugs caused an increase in the cardiac index without MPAP modification and an increase in PaO2 and Qs/Qt.

Conclusion

Dobutamine and INO have complementary effects on pulmonary circulation. Their association may be beneficial in the treatment of patients with mild to moderate pulmonary hypertension.
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Metadata
Title
Acute hemodynamic effects of inhaled nitric oxide, dobutamine and a combination of the two in patients with mild to moderate secondary pulmonary hypertension
Authors
Carmine D Vizza
Giorgio Della Rocca
Di Angelo Roma
Carlo Iacoboni
Federico Pierconti
Federico Venuta
Erino Rendina
Giovanni Schmid
Paolo Pietropaoli
Francesco Fedele
Publication date
01-12-2001
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2001
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc1069

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