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Critical Care
Published in: Critical Care 1/2012

Open Access 01-12-2012 | Poster presentation

AMP-activated protein kinase controls liposaccharide-induced hyperpermeability

Authors: D Castanares-Zapatero, M Overtus, D Communi, M Horckmans, L Bertrand, C Oury, C Lecut, P Laterre, S De man, C Sommereyns, S Horman, C Beauloye

Published in: Critical Care | Special Issue 1/2012

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Excerpt

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability. Our hypothesis is that AMPK controls sepsis-induced hyperpermeability in the heart and is involved in septic cardiomyopathy. …
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Metadata
Title
AMP-activated protein kinase controls liposaccharide-induced hyperpermeability
Authors
D Castanares-Zapatero
M Overtus
D Communi
M Horckmans
L Bertrand
C Oury
C Lecut
P Laterre
S De man
C Sommereyns
S Horman
C Beauloye
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10624

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