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Critical Care
Published in: Critical Care 1/2012

01-02-2012 | Commentary

Copeptin in aneurysmal subarachnoid hemorrhage

Author: Rafael J Tamargo

Published in: Critical Care | Issue 1/2012

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Abstract

Copeptin is a peptide derived from pre-provasospression along with arginine vasospressin. In the setting of aneurysmal subarachnoid hemorrhage (SAH), elevated serum copeptin levels correlate with vasospasm, inpatient mortality, mortality at 1 year, and poor functional outcome at 1 year. The potential role of serum copeptin levels in the management of patients with aneurysmal SAH is promising and should be explored further.
Literature
1.
Zhu XD, Chen JS, Zhou F, Liu QC, Chen G, Zhang JM: Detection of copeptin in peripheral blood of patients with aneurysmal subarachnoid hemorrhage. Crit Care 2011, 15: R288. 10.1186/cc10575PubMedCentralCrossRefPubMed
2.
Tamargo RJ, Walter KA, Oshiro EM: Aneurysmal subarachnoid hemorrhage: prognostic features and outcomes. New Horiz 1997, 5: 364-375.PubMed
3.
Chaichana KL, Pradilla G, Huang J, Tamargo RJ: Role of inflammation (leukocyte-endothelial cell interactions) in vasospasm after subarachnoid hemorrhage. World Neurosurg 2010, 73: 22-41. 10.1016/j.surneu.2009.05.027CrossRefPubMed
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Juvela S, Kuhmonen J, Siironen J: C-reactive protein as predictor for poor outcome after aneurysmal subarachnoid haemorrhage. Acta Neurochir (Wien) 2011, in press.
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Juvela S, Siironen J: D-dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage. Stroke 2006, 37: 1451-1456. 10.1161/01.STR.0000221710.55467.33CrossRefPubMed
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Katan M, Christ-Crain M: The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly 2010, 140: w13101.PubMed
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Morgenthaler NG, Struck J, Alonso C, Bergmann A: Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 2006, 52: 112-119. 10.1373/clinchem.2005.060038CrossRefPubMed
Metadata
Title
Copeptin in aneurysmal subarachnoid hemorrhage
Author
Rafael J Tamargo
Publication date
01-02-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10594

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