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01-12-2011 | Letter

Severity of community-acquired pneumonia treated with low-dose adjunctive corticosteroid

Authors: Katsunaka Mikami, Masaru Suzuki, Hiroshi Kitagawa, Masaki Kawakami, Nobuaki Hirota, Ayako Shimbara-Mikami, Yoshio Sakamoto

Published in: Critical Care | Issue 6/2011

Excerpt

We read with interest the report of the randomized double-blind controlled trial by Fernández-Serrano and colleagues [1] suggesting that the administration of methyl-prednisolone (MPDN) with ceftriaxone plus levofloxacin improves clinical variables in community-acquired pneumonia (CAP). Compared with randomly controlled studies in which patients benefited from corticosteroid treatment [2‐4], all patients of this study received the same antibiotics. It is striking that this study has overcome the problem that choice and dose of antibiotics may influence results. …

Fernández-Serrano S, Dorca J, Garcia-Vidal C, Fernández-Sabé N, Carratalà J, Fernández-Agüera A, Corominas M, Padrones S, Gudiol F, Manresa F: Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial. Crit Care 2011, 15: R96. 10.1186/cc10103PubMedCentralCrossRefPubMed

Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della Porta R, Giorgio C, Blasi F, Umberger R, Meduri GU: Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005, 171: 242-248.CrossRefPubMed

Mikami K, Suzuki M, Kitagawa H, Kawakami M, Hirota N, Yamaguchi H, Narumoto O, Kichikawa Y, Kawai M, Tashimo H, Arai H, Horiuchi T, Sakamoto Y: Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization. Lung 2007, 185: 249-255. 10.1007/s00408-007-9020-3CrossRefPubMed

Meijvis SC, Hardeman H, Remmelts HH, Heijligenberg R, Rijkers GT, van Velzen-Blad H, Voorn GP, van de Garde EM, Endeman H, Grutters JC, Bos WJ, Biesma DH: Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet 2011, 377: 2023-2030. 10.1016/S0140-6736(11)60607-7CrossRefPubMed

Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN: A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997, 336: 243-250. 10.1056/NEJM199701233360402CrossRefPubMed

Snijders D, Daniels JMA, de Graa3 CS, van der Werf TS, Boersma WG: Efficacy of corticosteroids in community-acquired pneumonia: a randomized, double-blinded clinical trial. Am J Respir Crit Care Med 2010, 181: 975-982. 10.1164/rccm.200905-0808OCCrossRefPubMed

Title: Severity of community-acquired pneumonia treated with low-dose adjunctive corticosteroid
Authors: Katsunaka Mikami
Masaru Suzuki
Hiroshi Kitagawa
Masaki Kawakami
Nobuaki Hirota
Ayako Shimbara-Mikami
Yoshio Sakamoto
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Critical Care / Issue 6/2011
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc10500

At a glance: The STEP trials

Springer Medicine

Severity of community-acquired pneumonia treated with low-dose adjunctive corticosteroid

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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