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Critical Care
Published in: Critical Care 5/2011

01-10-2011 | Commentary

Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time?

Author: Luis Ostrosky-Zeichner

Published in: Critical Care | Issue 5/2011

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Abstract

Invasive candidiasis is a major source of morbidity and mortality in critically ill patients. The creation and validation of clinical prediction rules to identify patients at high risk has given clinicians access to advanced management strategies, such as targeted prophylaxis, pre-emptive therapy, and protocolized empirical therapy.
Literature
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Ostrosky-Zeichner L, Kullberg BJ, Bow EJ, Hadley S, Leon C, Nucci M, Patterson TF, Perfect JR: Early treatment of candidemia in adults: a review. Med Mycol. 2011, 49: 113-120. 10.3109/13693786.2010.512300.CrossRef
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Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, Kauffman CA, Kett D, Larsen RA, Morrison V, Nucci M, Pappas PG, Bradley ME, Major S, Zimmer L, Wallace D, Dismukes WE, Rex JH: Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis. 2007, 26: 271-276. 10.1007/s10096-007-0270-z.CrossRef
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Leon C, Ruiz-Santana S, Saavedra P, Almirante B, Nolla-Salas J, Alvarez-Lerma F, Garnacho-Montero J, Leon MA: A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006, 34: 730-737. 10.1097/01.CCM.0000202208.37364.7D.CrossRef
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León C, Ruiz-Santana S, Saavedra P, Galván B, Blanco A, Castro C, Balasini C, Utande-Vázquez A, González de Molina FJ, Blasco-Navalproto MA, López MJ, Charles PE, Martín E, Hernández-Viera MA, Cava Study Group: Usefulness of the "Candida score" for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med. 2009, 37: 1624-1633. 10.1097/CCM.0b013e31819daa14.CrossRef
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Ostrosky-Zeichner L, Pappas PG, Shoham S, Reboli A, Barron MA, Sims C, Wood C, Sobel JD: Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit. Mycoses. 2011, 54: 46-51. 10.1111/j.1439-0507.2009.01756.x.CrossRef
Metadata
Title
Clinical prediction rules for invasive candidiasis in the ICU: ready for prime time?
Author
Luis Ostrosky-Zeichner
Publication date
01-10-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10422

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